INT75688

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Context Info
Confidence 0.30
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 11.73
Pain Relevance 4.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (KITLG) signal transduction (KITLG) extracellular space (KITLG)
extracellular region (KITLG) cell adhesion (KITLG) plasma membrane (KITLG)
Anatomy Link Frequency
stem cell 7
mast cell 3
macrophage 1
reproductive organs 1
bone marrow 1
KITLG (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 255 99.56 Very High Very High Very High
nociceptor 3 98.60 Very High Very High Very High
interstitial cystitis 13 98.36 Very High Very High Very High
Chronic pancreatitis 10 96.84 Very High Very High Very High
Thermal hyperalgesia 2 95.00 High High
cytokine 27 93.84 High High
hypoalgesia 1 93.76 High High
anesthesia 10 91.72 High High
metalloproteinase 57 90.56 High High
Inflammation 40 89.28 High High
Disease Link Frequency Relevance Heat
Stomach Cancer 210 99.80 Very High Very High Very High
Rheumatoid Arthritis 255 99.56 Very High Very High Very High
Interstitial Cystitis 13 98.36 Very High Very High Very High
Cancer 357 97.68 Very High Very High Very High
Neurodegenerative Disease 4 96.96 Very High Very High Very High
Pancreatitis 10 96.84 Very High Very High Very High
Hyperalgesia 2 95.00 High High
Emergencies 1 94.08 High High
Osteoma 42 94.04 High High
Hypoalagesia 1 93.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical examination revealed positive reactivity to C-kit protein and CD34.
C-kit protein Binding (reactivity) of
1) Confidence 0.30 Published 2003 Journal J. Korean Med. Sci. Section Abstract Doc Link 14555833 Disease Relevance 0.58 Pain Relevance 0.08
In cells stimulated by IL-4 MCP-1 mRNA was up-regulated by a mean factor +/- SD of 3.5 +/- 1.3, IL-6 mRNA was up-regulated by 3.8 +/- 1.3, the soluble form of SCF was up-regulated by 3.2 +/- 0.6 and the membrane bound form of SCF was up-regulated by 7.9 +/- 5.6.
SCF Binding (bound) of
2) Confidence 0.28 Published 2006 Journal J. Urol. Section Body Doc Link 16407046 Disease Relevance 0.15 Pain Relevance 0
This study reports an expression of the protooncogene c-kit and its ligand stem cell factor (SCF) in gastric carcinoma cell lines [18].
stem cell factor Binding (ligand) of in stem cell associated with stomach cancer
3) Confidence 0.25 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.10 Pain Relevance 0
This study reports an expression of the protooncogene c-kit and its ligand stem cell factor (SCF) in gastric carcinoma cell lines [18].
SCF Binding (ligand) of in stem cell associated with stomach cancer
4) Confidence 0.25 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.11 Pain Relevance 0
The first three are responsible for binding with stem cell factor (SCF).
stem cell factor Binding (binding) of in stem cell
5) Confidence 0.24 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 0.45 Pain Relevance 0
The first three are responsible for binding with stem cell factor (SCF).
SCF Binding (binding) of in stem cell
6) Confidence 0.24 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 0.45 Pain Relevance 0
As such, it was not possible to examine the associations of the KDQOL-SF™ with clinical parameters or clinical outcome.
KDQOL-SF Binding (associations) of
7) Confidence 0.21 Published 2010 Journal BMC Nephrol Section Body Doc Link PMC3014913 Disease Relevance 0.18 Pain Relevance 0
Following a complex formation with SCF the intracellular domain is phosphorylated and new sites are provided for cytoplasmatic messengers e.g.
SCF Binding (formation) of
8) Confidence 0.21 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 0.38 Pain Relevance 0
We also report the management of SCF linkage presented in the same patient, performing duraplasty with fascia lata.


SCF Binding (linkage) of in fascia
9) Confidence 0.16 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2576271 Disease Relevance 0.53 Pain Relevance 0.03
It remains equivocal whether the ghrelin system is developmentally regulated in fetal reproductive organs, and whether there are interactions with other paracrine regulators of gonadal development such as SCF.
SCF Binding (interactions) of in reproductive organs
10) Confidence 0.05 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0.08 Pain Relevance 0
These data are consistent with the putative involvement of fetal testicular ghrelin and its functional receptor in the paracrine regulation of Leydig and germ cell development, possibly via interactions with SCF and PCNA.


SCF Binding (interactions) of in germ cell
11) Confidence 0.05 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0.17 Pain Relevance 0
Stem cell factor (SCF), also known as c-kit ligand, is now recognized as the key molecule responsible for mast cell proliferation and is known to exert its action through specific surface receptors.
SCF Binding (recognized) of in mast cell
12) Confidence 0.05 Published 1998 Journal Urology Section Abstract Doc Link 9609630 Disease Relevance 0.61 Pain Relevance 0.70
Significantly, inactivation of the Fbx4 ligase is the result of mutations in N-terminal regulatory regions of Fbx4 that disrupt ligase dimerization, thereby revealing the biological significance of SCF ligase oligomerization.
SCF Binding (oligomerization) of
13) Confidence 0.05 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.71 Pain Relevance 0
SCF/c-kit interaction plays a very important role in the development, function, and survival of rodent islets of Langerhans [14, 15].
SCF Binding (interaction) of in islets of Langerhans
14) Confidence 0.04 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
SCs produce SCF or c-kit ligand that binds to and activates the transmembrane tyrosine kinase receptor c-kit.
SCF Binding (binds) of
15) Confidence 0.04 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
Stem cell factor (SCF), also known as c-kit ligand, is now recognized as the key molecule responsible for mast cell proliferation and is known to exert its action through specific surface receptors.
SCF Binding (exert) of in mast cell
16) Confidence 0.04 Published 1998 Journal Urology Section Abstract Doc Link 9609630 Disease Relevance 0.61 Pain Relevance 0.70
Furthermore, the presence of stem cell factor (SCF), the main mast cell growth factor, and of its receptor, c-kit, was also assessed.
SCF Binding (presence) of in mast cell
17) Confidence 0.03 Published 2001 Journal Hum. Pathol. Section Abstract Doc Link 11727255 Disease Relevance 1.03 Pain Relevance 0.78
However, the SF-6D has a clear limitation in severe RA patients, which has not previously been demonstrated.
SF-6D Spec (clear) Binding (limitation) of associated with rheumatoid arthritis
18) Confidence 0.03 Published 2009 Journal Qual Life Res Section Body Doc Link PMC2761817 Disease Relevance 0.66 Pain Relevance 0.16
Acute activation of c-Kit by its ligand, SCF, resulted in a reduced thermal threshold and potentiation of heat-activated currents in isolated small-diameter neurons and thermal hyperalgesia in mice.
SCF Binding (ligand) of in neurons associated with thermal hyperalgesia
19) Confidence 0.02 Published 2007 Journal Neuron Section Abstract Doc Link 18054864 Disease Relevance 0.43 Pain Relevance 0.37
Other research teams have reported that a combination of G-CSF and stem cell factor (SCF) may be capable of inducing neural progenitor cell growth, thereby producing an enhanced plastic effect during brain repair [33], [39].
SCF Binding (combination) of in stem cell
20) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.33 Pain Relevance 0.12

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