INT7569

Context Info Confidence 0.70 First Reported 1991 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 19 Total Number 19 Disease Relevance 2.60 Pain Relevance 6.17

cytosol (Th) mitochondrion (Th) nucleus (Th) response to stress (Th) cytoplasm (Th)

Anatomy Link Frequency locus coeruleus 6 neuronal 2 neurons 2 adrenal medulla 2 ovaries 2 Th (Rattus norvegicus)

Pain Link Frequency Relevance Heat Enkephalin 25 100.00 Catecholamine 22 100.00 Locus ceruleus 5 100.00 Neuropeptide 2 100.00 Morphine 26 99.56 medulla 4 99.36 Dopamine 11 99.24 monoamine 1 99.24 antagonist 2 98.44 Clonidine 6 97.92

Disease Link Frequency Relevance Heat Polycystic Ovary Syndrome 87 99.66 Pheochromocytoma 5 98.76 Ganglion Cysts 1 98.16 Stress 20 98.04 Depression 5 90.24 Convulsion 1 82.08 Attention Deficit Hyperactivity Disorder 4 78.68 Acquired Immune Deficiency Syndrome Or Hiv Infection 1 74.08 Hyperphagia 1 71.52 Sleep Disorders 1 70.84

Sentences Mentioned In

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Event

Anatomy

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Speculation

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Tyrosine hydroxylase (TH) mRNA levels in the locus coeruleus (LC) were significantly and progressively increased by 18, 42 and 68% after 7, 14 or 28 days of isolation, respectively.

Positive_regulation (increased) of Transcription (levels) of Tyrosine hydroxylase in locus coeruleus associated with locus ceruleus

1) Confidence 0.70 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1684631 Disease Relevance 0.22 Pain Relevance 0.32

Adrenal tyrosine hydroxylase (TH) mRNA level was significantly elevated in both PH and laparotomized rats, however 24 h after the surgery they returned to the baseline.

Positive_regulation (elevated) of Transcription (level) of TH

2) Confidence 0.69 Published 1999 Journal Endocr Regul Section Body Doc Link 10700082 Disease Relevance 0 Pain Relevance 0

Tyrosine hydroxylase (TH) gene transcription rate is stimulated by cyclic AMP in cultured rat pheochromocytoma cells.

Positive_regulation (stimulated) of Transcription (transcription) of TH associated with pheochromocytoma

3) Confidence 0.69 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7595476 Disease Relevance 0.16 Pain Relevance 0

Tyrosine hydroxylase (TH) mRNA levels in the locus coeruleus (LC) were significantly and progressively increased by 18, 42 and 68% after 7, 14 or 28 days of isolation, respectively.

Positive_regulation (increased) of Transcription (levels) of TH in locus coeruleus associated with locus ceruleus

4) Confidence 0.50 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1684631 Disease Relevance 0.22 Pain Relevance 0.32

When adrenal medullary cells are cultured in vitro, tyrosine hydroxylase (TH) mRNA, preproenkephalin (PPEnk) mRNA, and methionine enkephalin (Mek) immunoreactivity was markedly increased compared with intact adrenal medullary cells in situ, suggesting an increased biosynthesis of catecholamines and enkephalin-containing peptides.

Positive_regulation (increased) of Transcription (immunoreactivity) of tyrosine hydroxylase associated with catecholamine and enkephalin

5) Confidence 0.50 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10683300 Disease Relevance 0 Pain Relevance 0.28

When adrenal medullary cells are cultured in vitro, tyrosine hydroxylase (TH) mRNA, preproenkephalin (PPEnk) mRNA, and methionine enkephalin (Mek) immunoreactivity was markedly increased compared with intact adrenal medullary cells in situ, suggesting an increased biosynthesis of catecholamines and enkephalin-containing peptides.

Positive_regulation (increased) of Transcription (immunoreactivity) of TH associated with catecholamine and enkephalin

6) Confidence 0.50 Published 2000 Journal Exp. Neurol. Section Abstract Doc Link 10683300 Disease Relevance 0 Pain Relevance 0.28

Ether inhalation increased adrenal tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) mRNA expression as well as adrenal epinephrine (E) concentration in control rats but not in prenatally morphine-exposed (PM) animals.

Positive_regulation (increased) of Transcription (expression) of TH associated with morphine

7) Confidence 0.50 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15896472 Disease Relevance 0.32 Pain Relevance 0.71

Ether inhalation increased adrenal tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) mRNA expression as well as adrenal epinephrine (E) concentration in control rats but not in prenatally morphine-exposed (PM) animals.

Positive_regulation (increased) of Transcription (expression) of tyrosine hydroxylase associated with morphine

8) Confidence 0.50 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15896472 Disease Relevance 0.32 Pain Relevance 0.71

Tyrosine hydroxylase (TH) gene transcription rate is stimulated by cyclic AMP in cultured rat pheochromocytoma cells.

Positive_regulation (stimulated) of Transcription (transcription) of Tyrosine hydroxylase associated with pheochromocytoma

9) Confidence 0.50 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7595476 Disease Relevance 0.16 Pain Relevance 0

Tyrosine hydroxylase (TH) mRNA levels were increased nearly 7-fold (686 +/- 71%) 24 hr after the first reserpine dose and declined thereafter.

Positive_regulation (increased) of Transcription (levels) of TH

10) Confidence 0.49 Published 1991 Journal Mol. Pharmacol. Section Abstract Doc Link 1717819 Disease Relevance 0 Pain Relevance 0.18

The levels of PPenk and TH mRNAs were significantly increased (5-fold and 3-fold, respectively) in the adrenal 6 hr after MTZ treatment.

Positive_regulation (increased) of Transcription (levels) of TH

11) Confidence 0.45 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8102782 Disease Relevance 0.08 Pain Relevance 0.27

Tyrosine hydroxylase (TH) mRNA levels were increased nearly 7-fold (686 +/- 71%) 24 hr after the first reserpine dose and declined thereafter.

Positive_regulation (increased) of Transcription (levels) of Tyrosine hydroxylase

12) Confidence 0.45 Published 1991 Journal Mol. Pharmacol. Section Abstract Doc Link 1717819 Disease Relevance 0 Pain Relevance 0.18

Butyrate has been shown to induce tyrosine hydroxylase, the rate-limiting enzyme of catecholamine synthesis, and enkephalin neuropeptide gene transcription, suggesting a role in perinatal sympathoadrenal stress-adaptation.

Positive_regulation (induce) of Transcription (transcription) of tyrosine hydroxylase associated with stress, catecholamine, neuropeptide and enkephalin

13) Confidence 0.39 Published 2004 Journal Pediatr. Res. Section Abstract Doc Link 14739357 Disease Relevance 0.18 Pain Relevance 0.24

The activation of the sympathetic nervous system after EV injection has been evidenced by enhanced TH activity in the ovaries of PCO rats [9] and by increase of TH mRNA expression in the catecholaminergic cells of the celiac ganglion selectively projecting to the ovaries [10].

Positive_regulation (increase) of Transcription (expression) of TH in ovaries associated with ganglion cysts and polycystic ovary syndrome

14) Confidence 0.35 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1175857 Disease Relevance 0.43 Pain Relevance 0.38

Nuclear run-on assays demonstrated that butyrate increases endogenous TH gene transcription.

Positive_regulation (increases) of Transcription (transcription) of TH gene

15) Confidence 0.27 Published 2006 Journal Brain Res. Section Abstract Doc Link 16854387 Disease Relevance 0 Pain Relevance 0

Daily administration (5 mg/kg, i.p.) of the selective 5-hydroxytryptophan (5-HT) reuptake inhibitor fluoxetine, the selective alpha 2-adrenergic receptor antagonist idazoxan, and the nonspecific monoamine oxidase A and B inhibitor phenelzine increased tyrosine hydroxylase mRNA levels by 70-150% in the locus coeruleus after 2 weeks of drug and by 71-115% after 8 weeks.

Positive_regulation (increased) of Transcription (levels) of tyrosine hydroxylase in locus coeruleus associated with locus ceruleus, antagonist, monoamine and fluoxetine

16) Confidence 0.23 Published 1992 Journal Brain Res. Section Abstract Doc Link 1351783 Disease Relevance 0.52 Pain Relevance 0.73

In vivo, PNMT and tyrosine hydroxylase (TH) mRNA levels increase in rat adrenal medulla after a single injection of clonidine.

Positive_regulation (increase) of Transcription (levels) of TH in adrenal medulla associated with medulla and clonidine

17) Confidence 0.22 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7643129 Disease Relevance 0 Pain Relevance 0.50

Accordingly, in the present studies we examined the effects of morphine on various components of this dopamine system using as our index of altered DA neuronal activity, the changes which occur in tyrosine hydroxylase (TH) mRNA levels following morphine.

Positive_regulation (occur) of Transcription (levels) of tyrosine hydroxylase in neuronal associated with dopamine and morphine

18) Confidence 0.04 Published 1994 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7516996 Disease Relevance 0 Pain Relevance 0.92

Also described is evidence that concomitant with preovulatory LH surges and increases in hypothalamic NE secretion there also is an increase in tyrosine hydroxylase mRNA levels and in activity within medullary A1 noradrenergic neurons.

Positive_regulation (increase) of Transcription (levels) of tyrosine hydroxylase in neurons

19) Confidence 0.01 Published 1994 Journal Acta. Biol. Hung. Section Abstract Doc Link 7725817 Disease Relevance 0 Pain Relevance 0.15

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