INT75694

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Context Info
Confidence 0.60
First Reported 1998
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.08
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CEL) extracellular space (CEL) small molecule metabolic process (CEL)
extracellular region (CEL) lipid metabolic process (CEL) cytoplasm (CEL)
Anatomy Link Frequency
macrophage 3
endothelial cell 2
colons 2
brain 2
choroidal cells 2
CEL (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1 100.00 Very High Very High Very High
depression 2 99.76 Very High Very High Very High
palliative 1 98.44 Very High Very High Very High
cINOD 3 98.24 Very High Very High Very High
Morphine 12 97.70 Very High Very High Very High
Central nervous system 9 92.96 High High
Inflammatory response 1 86.88 High High
Opioid 2 75.00 Quite High
Analgesic 4 69.36 Quite High
Paracetamol 3 68.52 Quite High
Disease Link Frequency Relevance Heat
Glioma 45 99.98 Very High Very High Very High
Adhesions 6 99.96 Very High Very High Very High
Depression 2 99.76 Very High Very High Very High
Apoptosis 68 99.40 Very High Very High Very High
Hypersensitivity 10 99.36 Very High Very High Very High
Glioblastoma 18 99.08 Very High Very High Very High
Aging 11 97.12 Very High Very High Very High
Brain Tumor 60 96.96 Very High Very High Very High
Stress 34 96.60 Very High Very High Very High
Cancer 108 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, responses of T cells are depressed by morphine, as assessed by inhibition of induction of delayed-type hypersensitivity reactions and cytotoxic T-cell activity, modulation of T-cell antigen expression, and depression of responses to T-cell mitogens.
Regulation (modulation) of Gene_expression (expression) of cell in cytotoxic T-cell associated with depression, hypersensitivity and morphine
1) Confidence 0.60 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9610671 Disease Relevance 0.29 Pain Relevance 0.64
Although there is virtually no information regarding the regulation of expression of endothelial cell adhesion molecules (ECAMs) in experimental NSAID-induced gastropathy, the nuclear transcription factor KB (NFKB) may represent a potential modulator of transcriptional activation of ECAM expression.
Regulation (regulation) of Gene_expression (expression) of cell in endothelial cell associated with cinod and adhesions
2) Confidence 0.60 Published 1998 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9872503 Disease Relevance 0.39 Pain Relevance 0.25
RESULTS: Significantly lower expression of PAR-1 and higher expression of mast cell tryptase was detected in the colons of patients, with statistically unchanged expression of PAR-2.
Regulation (detected) of Gene_expression (expression) of cell in colons
3) Confidence 0.44 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19430717 Disease Relevance 0.08 Pain Relevance 0
The VHL protein takes part in cell cycle
Regulation (part) of Gene_expression (cycle) of cell
4) Confidence 0.03 Published 2008 Journal Advances in Urology Section Body Doc Link PMC2581742 Disease Relevance 1.58 Pain Relevance 0.32
However, enzymatic synovial disaggregation may be associated with changes in cell surface marker expression, which needs to be considered when using this approach.
Regulation (changes) of Gene_expression (expression) of cell
5) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0 Pain Relevance 0
We detected influences on macrophage and B-cell marker expression relying on mimicking experiments with PBMC suspensions.
Regulation (influences) of Gene_expression (expression) of cell in macrophage
6) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.51 Pain Relevance 0.06
We detected influences on macrophage and B-cell marker expression relying on mimicking experiments with PBMC suspensions.
Regulation (influences) of in B-cell Gene_expression (expression) of cell in macrophage
7) Confidence 0.00 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875643 Disease Relevance 0.51 Pain Relevance 0.06
Whereas glioma cell lines expressing mutant p53 are sensitized to temozolomide, the status of p53 does not seem to affect the response of brain tumor stem cells treated with this drug [141].
Regulation (sensitized) of Gene_expression (expressing) of cell in brain associated with brain tumor and glioma
8) Confidence 0.00 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 1.26 Pain Relevance 0.10
Correspondingly, RPE and choroidal cells alter the expression of genes for cytokines, matrix organization, cell adhesion, and apoptosis [2, 34, 48, 49, 53, 61, 116, 183].
Regulation (alter) of Gene_expression (expression) of cell in choroidal cells associated with apoptosis, adhesions and cytokine
9) Confidence 0.00 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647152 Disease Relevance 1.37 Pain Relevance 0.09

General Comments

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