INT7570

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Context Info
Confidence 0.66
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 6.60
Pain Relevance 7.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Crhr1) response to stress (Crhr1) signal transducer activity (Crhr1)
Anatomy Link Frequency
amygdala 5
hypothalamus 1
brain 1
anterior pituitary 1
Crhr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 7 99.70 Very High Very High Very High
amygdala 116 99.68 Very High Very High Very High
Morphine 15 99.54 Very High Very High Very High
fluoxetine 6 99.36 Very High Very High Very High
antidepressant 8 99.14 Very High Very High Very High
Pain 71 98.48 Very High Very High Very High
Visceral pain 4 98.48 Very High Very High Very High
Locus ceruleus 2 97.00 Very High Very High Very High
tolerance 7 95.88 Very High Very High Very High
Neuropathic pain 9 93.04 High High
Disease Link Frequency Relevance Heat
Injury 7 99.70 Very High Very High Very High
Nociception 8 99.28 Very High Very High Very High
Pain 76 98.48 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

4 98.48 Very High Very High Very High
Stress 4 98.16 Very High Very High Very High
Depression 22 93.04 High High
Neuropathic Pain 9 93.04 High High
Anxiety Disorder 63 92.88 High High
Colitis 2 88.72 High High
Sleep Disorders 2 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CCI increased the expression of corticotrophin releasing hormone mRNA in the central amygdala, and not the paraventricular nucleus of the hypothalamus or the bed nucleus of the stria terminalis.
Transcription (expression) of corticotrophin releasing hormone in amygdala associated with eae and amygdala
1) Confidence 0.66 Published 2006 Journal Physiol. Behav. Section Abstract Doc Link 16647726 Disease Relevance 1.95 Pain Relevance 1.47
This study analyzed the effects of CRF on nociceptive processing in CeLC neurons and the contribution of CRF1 and CRF2 receptors and protein kinases A and C.
Transcription (contribution) of CRF1 in CeLC associated with nociception and amygdala
2) Confidence 0.64 Published 2008 Journal J. Neurophysiol. Section Abstract Doc Link 18171711 Disease Relevance 0.78 Pain Relevance 0.66
Increased expression of CRF1 receptor mRNA was detected in the amygdala in a model of somato-visceral pain induced by intra-peritoneal acetic acid [46].
Transcription (detected) of CRF1 receptor in amygdala associated with visceral pain and amygdala
3) Confidence 0.50 Published 2007 Journal Mol Pain Section Body Doc Link PMC1891279 Disease Relevance 1.30 Pain Relevance 1.51
Increased expression of CRF1 receptor mRNA was detected in the amygdala in a model of somato-visceral pain induced by intra-peritoneal acetic acid [46].
Transcription (expression) of CRF1 receptor in amygdala associated with visceral pain and amygdala
4) Confidence 0.50 Published 2007 Journal Mol Pain Section Body Doc Link PMC1891279 Disease Relevance 1.30 Pain Relevance 1.48
In situ hybridization revealed increased corticotrophin releasing hormone (CRH) mRNA expression in the dorsomedial parvocellular paraventricular nucleus (pPVN) and increased anterior pituitary pro-opiomelanocortin mRNA expression 4 h after IL-1beta in virgins; these responses were absent in pregnant rats.
Transcription (expression) of corticotrophin releasing hormone in anterior pituitary
5) Confidence 0.47 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15917452 Disease Relevance 0 Pain Relevance 0.22
The 3 drugs decreased corticotropin-releasing hormone mRNA levels by 30-48% in the paraventricular nucleus of the hypothalamus.
Transcription (levels) of corticotropin-releasing hormone in hypothalamus
6) Confidence 0.45 Published 1992 Journal Brain Res. Section Abstract Doc Link 1351783 Disease Relevance 0.48 Pain Relevance 0.71
In the present study, we investigated the effect of acute and chronic morphine administration on the level of CRF1 and melanocortin 4 receptor (MC4-R) mRNAs in the rat amygdala by quantitative real-time PCR method.
Transcription (level) of CRF1 in amygdala associated with amygdala and morphine
7) Confidence 0.42 Published 2003 Journal Brain Res. Section Abstract Doc Link 14568335 Disease Relevance 0 Pain Relevance 0.96
The antidepressants fluoxetine, idazoxan and phenelzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain: therapeutic implications.
Transcription (levels) of corticotropin-releasing hormone in brain associated with antidepressant and fluoxetine
8) Confidence 0.34 Published 1992 Journal Brain Res. Section Title Doc Link 1351783 Disease Relevance 0.59 Pain Relevance 0.59

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