INT75719

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Context Info
Confidence 0.21
First Reported 1998
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.06
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxadr) cell adhesion (Cxadr) mitochondrion organization (Cxadr)
plasma membrane (Cxadr) nucleus (Cxadr) protein complex (Cxadr)
Anatomy Link Frequency
nerves 1
Cxadr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 3 100.00 Very High Very High Very High
qutenza 7 98.84 Very High Very High Very High
Pain 3 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 26 60.76 Quite High
Parathyroid Cancer 3 50.00 Quite Low
Chronic Renal Failure 7 22.52 Low Low
Pruritus 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Hypercalcemia 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Renal Disease 3 5.00 Very Low Very Low Very Low
Pyelonephritis 2 5.00 Very Low Very Low Very Low
Aids-related Complex 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunocytochemical studies showed that capsaicin treatment significantly reduced the density of nerves staining positively for calcitonin gene-related peptide (CGRP) and for the CaR (CGRP density: control, 51.1 +/- 3.9 microns2/mm2; capsaicin treated, 31.4 +/- 2.8 microns2/mm2, P = 0.01; control CaR density, 46 +/- 4 microns2/mm2, n = 7; capsaicin-treated CaR density, 24 +/- 4 microns2/mm2, n = 8, P = 0.002).
Regulation (control) of CaR in nerves associated with qutenza and calcitonin gene-related peptide
1) Confidence 0.21 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9612376 Disease Relevance 0 Pain Relevance 0.66
It increases the sensitivity of the CaR to activation by extracellular calcium and thus suppresses PTH release, while simultaneously lowering levels of serum P and Ca, and Ca × P [13,20–23].
Regulation (sensitivity) of CaR
2) Confidence 0.01 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2644631 Disease Relevance 0.06 Pain Relevance 0

General Comments

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