INT7572

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Context Info
Confidence 0.45
First Reported 1992
Last Reported 2010
Negated 1
Speculated 9
Reported most in Abstract
Documents 8
Total Number 17
Disease Relevance 5.60
Pain Relevance 8.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Crhr1) response to stress (Crhr1) signal transducer activity (Crhr1)
Anatomy Link Frequency
brain 4
articular 1
plasma 1
neurons 1
sympathetic 1
Crhr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 40 100.00 Very High Very High Very High
Pain 21 100.00 Very High Very High Very High
narcan 5 100.00 Very High Very High Very High
antagonist 30 99.96 Very High Very High Very High
agonist 4 99.96 Very High Very High Very High
antidepressant 20 99.88 Very High Very High Very High
Perioperative pain 2 99.84 Very High Very High Very High
methadone 4 99.52 Very High Very High Very High
fluoxetine 7 99.48 Very High Very High Very High
amygdala 26 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 15 99.84 Very High Very High Very High
Post Operative Pain 2 99.84 Very High Very High Very High
Stress 25 99.64 Very High Very High Very High
Urological Neuroanatomy 5 98.32 Very High Very High Very High
Arthritis 18 97.88 Very High Very High Very High
Drug Dependence 3 96.16 Very High Very High Very High
INFLAMMATION 2 95.40 Very High Very High Very High
Anxiety Disorder 21 94.00 High High
Injury 1 91.88 High High
Depression 16 91.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The possible effect of different corticotropin-releasing factor receptor (CRFR) antagonists (alpha-helical CRF, CP-154,526 and AS-30) on the maintenance and reactivation of morphine-conditioned place preference (CPP) induced by morphine or footshock stress, respectively, were investigated in rats.
Spec (possible) Regulation (effect) of corticotropin-releasing factor receptor associated with stress, antagonist and morphine
1) Confidence 0.45 Published 2000 Journal Neuroreport Section Abstract Doc Link 10943688 Disease Relevance 0.32 Pain Relevance 0.60
The possible effect of different corticotropin-releasing factor receptor (CRFR) antagonists (alpha-helical CRF, CP-154,526 and AS-30) on the maintenance and reactivation of morphine-conditioned place preference (CPP) induced by morphine or footshock stress, respectively, were investigated in rats.
Spec (possible) Regulation (effect) of CRFR associated with stress, antagonist and morphine
2) Confidence 0.45 Published 2000 Journal Neuroreport Section Abstract Doc Link 10943688 Disease Relevance 0.32 Pain Relevance 0.60
Effects of corticotropin-releasing factor receptor-1 antagonists on the brain stress system responses to morphine withdrawal.
Regulation (Effects) of corticotropin-releasing factor receptor-1 in brain associated with stress, antagonist, withdrawal and morphine
3) Confidence 0.44 Published 2010 Journal Mol. Pharmacol. Section Title Doc Link 20159948 Disease Relevance 0.57 Pain Relevance 0.90
These findings also suggest that variations in the CRHR1 gene may affect response to CRHR1 agonists or antagonists.
Spec (may) Regulation (affect) of CRHR1 gene associated with antagonist and agonist
4) Confidence 0.43 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 15365580 Disease Relevance 0.38 Pain Relevance 0.35
These findings also suggest that variations in the CRHR1 gene may affect response to CRHR1 agonists or antagonists.
Regulation (response) of CRHR1 associated with antagonist and agonist
5) Confidence 0.43 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 15365580 Disease Relevance 0.32 Pain Relevance 0.35
This study determined the effects of CRF1 and CRF2 receptor antagonists in CeLC neurons in an arthritis pain model.
Spec (determined) Regulation (effects) of CRF1 in neurons associated with pain, antagonist, amygdala and arthritis
6) Confidence 0.42 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17392412 Disease Relevance 0.67 Pain Relevance 0.80
Differential effects of CRF1 and CRF2 receptor antagonists on pain-related sensitization of neurons in the central nucleus of the amygdala.
Regulation (effects) of CRF1 in nucleus associated with pain, antagonist and amygdala
7) Confidence 0.42 Published 2007 Journal J. Neurophysiol. Section Title Doc Link 17392412 Disease Relevance 0.60 Pain Relevance 0.91
To investigate the role of CRF1 receptors in physiological responses to surgical stress, we analyzed the effects of two different non-peptide selective CRF1 receptor antagonists (JTC-017 and CP-154,526) and a peptide non-selective CRF receptor antagonist (astressin) on laparotomy-induced sympathetic nervous responses in isoflurane-anesthetized rats.
Spec (analyzed) Regulation (effects) of CRF1 in sympathetic associated with stress, antagonist and isoflurane
8) Confidence 0.42 Published 2005 Journal Brain Res. Section Abstract Doc Link 15862795 Disease Relevance 0.19 Pain Relevance 0.18
Region-specific effects of brain corticotropin-releasing factor receptor type 1 blockade on footshock-stress- or drug-priming-induced reinstatement of morphine conditioned place preference in rats.
Regulation (effects) of brain corticotropin-releasing factor receptor type 1 in brain associated with stress and morphine
9) Confidence 0.39 Published 2006 Journal Psychopharmacology (Berl.) Section Title Doc Link 16374599 Disease Relevance 0.19 Pain Relevance 0.47
The antidepressants fluoxetine, idazoxan and phenelzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain: therapeutic implications.
Spec (implications) Regulation (alter) of corticotropin-releasing hormone in brain associated with antidepressant and fluoxetine
10) Confidence 0.39 Published 1992 Journal Brain Res. Section Title Doc Link 1351783 Disease Relevance 0.58 Pain Relevance 0.59
Antidepressant-like effects of the corticotropin-releasing factor 1 receptor antagonist, SSR125543, and the vasopressin 1b receptor antagonist, SSR149415, in a DRL-72 s schedule in the rat.
Regulation (effects) of corticotropin-releasing factor 1 receptor associated with antidepressant and antagonist
11) Confidence 0.35 Published 2006 Journal Neuropsychopharmacology Section Title Doc Link 16452986 Disease Relevance 0.23 Pain Relevance 0.43
In the present study, we investigated the effect of acute and chronic morphine administration on the level of CRF1 and melanocortin 4 receptor (MC4-R) mRNAs in the rat amygdala by quantitative real-time PCR method.
Spec (investigated) Regulation (effect) of CRF1 in amygdala associated with amygdala and morphine
12) Confidence 0.21 Published 2003 Journal Brain Res. Section Abstract Doc Link 14568335 Disease Relevance 0 Pain Relevance 0.96
Chronic steady-state methadone administration did not alter (a) corticotropin-releasing factor (CRF) mRNA in the hypothalamus, (b) proopiomelanocortin (POMC) and CRF type 1 receptor (CRF-R1) mRNAs in the anterior lobe and neurointermediate/posterior lobe of the pituitary, or (c) circulating levels of corticosterone.
Neg (not) Regulation (alter) of CRF-R1 in anterior lobe associated with methadone
13) Confidence 0.18 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8960861 Disease Relevance 0.08 Pain Relevance 0.67
AIM: To investigate the effects of corticotrophin (Cor) on corticotropin-releasing factor (CRF), brain-derived neurotrophic factor (BDNF), and its functional receptor trkB in the frontal cortex of complete Freud's adjuvant (CFA)-induced arthritic rats.
Spec (investigate) Regulation (effects) of corticotrophin in brain associated with urological neuroanatomy and arthritis
14) Confidence 0.05 Published 2000 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 11360665 Disease Relevance 0.41 Pain Relevance 0.15
Effects of corticotrophin on pain behavior and BDNF, CRF levels in frontal cortex of rats suffering from chronic pain.
Regulation (Effects) of corticotrophin in frontal cortex associated with pain, lasting pain and urological neuroanatomy
15) Confidence 0.04 Published 2000 Journal Acta Pharmacol. Sin. Section Title Doc Link 11360665 Disease Relevance 0.29 Pain Relevance 0.40
The objectives of this study were to determine whether the maternal plasma corticotrophin-releasing hormone (CRH) concentration influences the amount of uterine contractility induced by infused oxytocin during induction of labour, and secondly to assess changes in CRH and beta-endorphin in response to stress during labour.
Spec (whether) Regulation (influences) of corticotrophin-releasing hormone in plasma associated with stress
16) Confidence 0.03 Published 1994 Journal Eur. J. Endocrinol. Section Abstract Doc Link 8075786 Disease Relevance 0.16 Pain Relevance 0.07
Involvement of intra-articular corticotropin-releasing hormone in postoperative pain modulation.
Regulation (Involvement) of intra-articular corticotropin-releasing hormone in articular associated with narcan and perioperative pain
17) Confidence 0.00 Published 2007 Journal Clin J Pain Section Title Doc Link 17237662 Disease Relevance 0.27 Pain Relevance 0.51

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