INT7573

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Context Info
Confidence 0.67
First Reported 1986
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 38
Total Number 44
Disease Relevance 20.00
Pain Relevance 21.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Nr3c2) nucleus (Nr3c2) cytoplasm (Nr3c2)
Anatomy Link Frequency
hippocampus 3
amygdala 2
spinal 2
lumen 2
brain 1
Nr3c2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 31 100.00 Very High Very High Very High
noradrenaline 16 100.00 Very High Very High Very High
bDMF 76 99.92 Very High Very High Very High
fluoxetine 41 99.78 Very High Very High Very High
Endep 8 99.78 Very High Very High Very High
5HT 16 99.76 Very High Very High Very High
Morphine 16 99.62 Very High Very High Very High
substance P 174 99.56 Very High Very High Very High
Calcium channel 28 99.50 Very High Very High Very High
dexamethasone 275 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 559 100.00 Very High Very High Very High
Paralysis 4 99.38 Very High Very High Very High
Apoptosis 136 98.64 Very High Very High Very High
Pain 148 98.52 Very High Very High Very High
Anxiety Disorder 92 98.52 Very High Very High Very High
Death 26 98.32 Very High Very High Very High
Cancer 344 98.10 Very High Very High Very High
Nociception 151 98.04 Very High Very High Very High
Post-traumatic Stress Disorder 216 97.60 Very High Very High Very High
Hypersensitivity 3 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the behavioral level, increased MR function is implicated in decreased anxiety/fear related behaviors in animals.
Positive_regulation (increased) of MR associated with anxiety disorder
1) Confidence 0.67 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.94 Pain Relevance 0.23
A previous study showed that the activation of MR or GR blocked adrenalectomy-induced cell death.
Positive_regulation (activation) of MR associated with death
2) Confidence 0.67 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.59 Pain Relevance 0.23
The importance of the activation of MR and GR-mediated effect by glucocorticoid are observed in psychiatric disorders.
Positive_regulation (activation) of MR
3) Confidence 0.67 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 1.29 Pain Relevance 0.19
Morphine exposure prevents up-regulation of MR and GR binding sites in the brain of adult male and female rats due to prenatal stress.
Positive_regulation (up-regulation) of MR in brain associated with stress and morphine
4) Confidence 0.63 Published 2006 Journal Int. J. Dev. Neurosci. Section Title Doc Link 16698219 Disease Relevance 0.32 Pain Relevance 0.47
Aldosterone-induced activation of mineralocorticoid receptor, a member of the nuclear receptor family, results in increased tissue damage such as vascular inflammation and cardiac and perivascular fibrosis.
Positive_regulation (activation) of mineralocorticoid receptor associated with fibrosis, inflammation and vasculitis
5) Confidence 0.61 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20307534 Disease Relevance 0.35 Pain Relevance 0.35
This organization may be related to the different types of transmitter systems involved in mediating MLR function.
Positive_regulation (mediating) of MLR
6) Confidence 0.58 Published 1986 Journal Brain Res. Bull. Section Abstract Doc Link 3019486 Disease Relevance 0 Pain Relevance 0.12
Thus, animals with increased MR capacity have decreased neuroendocrine responsibility to stress [19].
Positive_regulation (increased) of MR associated with stress
7) Confidence 0.58 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 1.18 Pain Relevance 0.18
Behavioral reactivity and extinction of avoidance conditioning are impaired in adrenalectomized animals, restored with low dose corticosterone replacement in MR activation and impaired with high dose replacement in both MR and GR activation [18].
Positive_regulation (activation) of MR
8) Confidence 0.45 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.60 Pain Relevance 0.29
Western blotting result of MR and GR
Positive_regulation (result) of MR
9) Confidence 0.45 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.62 Pain Relevance 0.09
The activation of MR and GR or maintenance of MR- and GR-ir is an important factor affecting hippocampal neuronal survival [9].
Positive_regulation (activation) of MR in neuronal
10) Confidence 0.45 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.56 Pain Relevance 0.23
The data demonstrate that prenatal stress due to maternal saline injections up-regulates MR and GR binding in the hippocampus of adult male rats and this effect is prevented by prenatal morphine exposure.
Positive_regulation (up-regulates) of MR in hippocampus associated with stress, hippocampus and morphine
11) Confidence 0.42 Published 2006 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 16698219 Disease Relevance 0.40 Pain Relevance 0.76
These studies examined whether changes in hippocampal MR and GR could mediate both behavioral/emotional changes in psychiatric disorders.
Positive_regulation (hippocampal) of MR
12) Confidence 0.42 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 1.14 Pain Relevance 0.20
The second maneuver was performed to determine whether the blood pressure response obtained during paralysis was an artifact of electrical stimulation of the MLR.
Spec (whether) Positive_regulation (stimulation) of MLR in blood associated with paralysis
13) Confidence 0.41 Published 1992 Journal J. Appl. Physiol. Section Abstract Doc Link 1537705 Disease Relevance 0.36 Pain Relevance 0.15
The injection results suggest that electrical stimulation of the MLR activates cells rather than fibers of passage.
Positive_regulation (stimulation) of MLR
14) Confidence 0.41 Published 1992 Journal J. Appl. Physiol. Section Abstract Doc Link 1537705 Disease Relevance 0.31 Pain Relevance 0.12
Here, we examined the effects of benidipine and other calcium channel blockers on aldosterone-induced mineralocorticoid receptor activation using luciferase reporter assay system.
Positive_regulation (induced) of mineralocorticoid receptor associated with calcium channel
15) Confidence 0.38 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20307534 Disease Relevance 0.33 Pain Relevance 0.48
Results of analysis using optical isomers of benidipine indicated that inhibitory effect of aldosterone-induced mineralocorticoid receptor activation was independent of its primary blockade of calcium channels.
Positive_regulation (induced) of mineralocorticoid receptor associated with calcium channel
16) Confidence 0.38 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20307534 Disease Relevance 0.20 Pain Relevance 0.36
These results suggested that benidipine directly inhibits aldosterone-induced mineralocorticoid receptor activation, and the antagonistic activity might contribute to the drug's pleiotropic pharmacological features.
Positive_regulation (induced) of mineralocorticoid receptor
17) Confidence 0.38 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20307534 Disease Relevance 0.09 Pain Relevance 0.29
Our results showed that GR or MR activation significantly reduced open arm exploration on the elevated plus maze, a measure of anxiety-like behavior.
Positive_regulation (activation) of MR in arm associated with anxiety disorder
18) Confidence 0.37 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 19875699 Disease Relevance 0.65 Pain Relevance 0.83
Moreover, these studies suggested that the effects of Cort were dependent on both the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR); however, the specific contributions of these receptors to the interaction between corticosteroids and the amygdala are still unclear.
Positive_regulation (dependent) of MR in amygdala associated with corticosteroid and amygdala
19) Confidence 0.37 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 19875699 Disease Relevance 0.44 Pain Relevance 0.64
Moreover, these studies suggested that the effects of Cort were dependent on both the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR); however, the specific contributions of these receptors to the interaction between corticosteroids and the amygdala are still unclear.
Positive_regulation (dependent) of mineralocorticoid receptor in amygdala associated with corticosteroid and amygdala
20) Confidence 0.37 Published 2010 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 19875699 Disease Relevance 0.44 Pain Relevance 0.64

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