INT75736

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Context Info
Confidence 0.62
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.61
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
macrophage 2
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 8 99.98 Very High Very High Very High
Antinociceptive 4 99.44 Very High Very High Very High
melanocortin 1 receptor 1 99.40 Very High Very High Very High
opioid receptor 5 98.64 Very High Very High Very High
agonist 4 98.12 Very High Very High Very High
Pain 5 96.28 Very High Very High Very High
cytokine 1 95.28 Very High Very High Very High
tolerance 2 91.48 High High
antagonist 1 87.36 High High
Neuropathic pain 6 84.40 Quite High
Disease Link Frequency Relevance Heat
Necrosis 6 100.00 Very High Very High Very High
Cancer 6 100.00 Very High Very High Very High
Apoptosis 1 99.76 Very High Very High Very High
Targeted Disruption 2 99.00 Very High Very High Very High
Diabetes Mellitus 12 98.92 Very High Very High Very High
Pain 4 96.28 Very High Very High Very High
Systemic Lupus Erythematosus 9 94.00 High High
Disease 2 93.36 High High
Toxicity 2 92.40 High High
Arthralgia 1 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to explore the antinociceptive effect of lycopene and its effect on tumour necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) release in streptozotocin induced diabetic mice.
Regulation (effect) of Localization (release) of TNF-alpha associated with necrosis, diabetes mellitus, cancer and antinociceptive
1) Confidence 0.62 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18055235 Disease Relevance 1.44 Pain Relevance 0.66
The aim of the present study was to explore the antinociceptive effect of curcumin and its effect on tumour necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) release in streptozotocin induced diabetic mice.
Regulation (effect) of Localization (release) of TNF-alpha associated with necrosis, diabetes mellitus, cancer and antinociceptive
2) Confidence 0.45 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16584726 Disease Relevance 1.42 Pain Relevance 0.65
BLF caused an approximate 35% fall in IL-6 levels and even weaker effects (20% inhibition) on TNF-alpha release.
Regulation (effects) of Localization (release) of TNF-alpha
3) Confidence 0.38 Published 1998 Journal Arch. Immunol. Ther. Exp. (Warsz.) Section Abstract Doc Link 9613707 Disease Relevance 0.28 Pain Relevance 0.11
Morphine modulation of several immune functions, including macrophage phagocytosis and macrophage secretion of TNF-alpha, was not observed in the MOR-KO animals, suggesting that these functions are mediated by the classical mu-opioid receptor.
Regulation (modulation) of Localization (secretion) of TNF-alpha in macrophage associated with opioid receptor and morphine
4) Confidence 0.30 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9795212 Disease Relevance 0.17 Pain Relevance 0.85
UVA1 effects on DNA repair, cell-mediated immunosuppression, tumor necrosis factor alpha release, and apoptosis contrast markedly with those of ultraviolet B (UVB, 280-320 nm) radiation and afford a possible basis for the salutary action of this modality of treatment.
Regulation (effects) of Localization (release) of tumor necrosis factor associated with necrosis, cancer and apoptosis
5) Confidence 0.26 Published 1999 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 10537014 Disease Relevance 1.15 Pain Relevance 0.09
Regulation of TNF-alpha secretion by a specific melanocortin-1 receptor peptide agonist.
Regulation (Regulation) of Localization (secretion) of TNF-alpha associated with melanocortin 1 receptor and agonist
6) Confidence 0.10 Published 2003 Journal Peptides Section Title Doc Link 12895657 Disease Relevance 0.15 Pain Relevance 0.31

General Comments

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