INT7574

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Context Info
Confidence 0.54
First Reported 1992
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.26
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Nr3c2) nucleus (Nr3c2) cytoplasm (Nr3c2)
Anatomy Link Frequency
hippocampus 4
brain 2
Nr3c2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
corticosteroid 7 100.00 Very High Very High Very High
5HT 8 99.76 Very High Very High Very High
fluoxetine 8 99.72 Very High Very High Very High
Hippocampus 4 99.06 Very High Very High Very High
dexamethasone 3 97.44 Very High Very High Very High
antidepressant 13 96.20 Very High Very High Very High
antagonist 4 92.24 High High
noradrenaline 5 90.16 High High
Serotonin 1 89.04 High High
monoamine 4 87.08 High High
Disease Link Frequency Relevance Heat
Stress 6 100.00 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 3 79.24 Quite High
Depression 11 72.40 Quite High
Hyperphagia 2 53.68 Quite High
Sleep Disorders 2 53.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No consistent change in steroid hormone receptor mRNA levels was seen in the hippocampus with the 3 drugs, but fluoxetine and idazoxan increased the level of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) mRNA, respectively, after 8 weeks of drug administration.
Positive_regulation (increased) of Transcription (level) of MR in hippocampus associated with hippocampus and fluoxetine
1) Confidence 0.54 Published 1992 Journal Brain Res. Section Abstract Doc Link 1351783 Disease Relevance 0.30 Pain Relevance 0.62
No consistent change in steroid hormone receptor mRNA levels was seen in the hippocampus with the 3 drugs, but fluoxetine and idazoxan increased the level of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) mRNA, respectively, after 8 weeks of drug administration.
Positive_regulation (increased) of Transcription (level) of mineralocorticoid receptor in hippocampus associated with hippocampus and fluoxetine
2) Confidence 0.39 Published 1992 Journal Brain Res. Section Abstract Doc Link 1351783 Disease Relevance 0.30 Pain Relevance 0.62
To examine this possibility, we compared the ability of THP, its precursor progesterone (P4), and the glucocorticoids dexamethasone (DEX) and corticosterone (CORT) to influence the pituitary-adrenal response to acute emotional stress and the adrenalectomy-induced increase in the gene transcription of the stress-related peptide arginine vasopressin (AVP) and of corticosteroid receptors (MR and GR) in the brain.
Positive_regulation (increase) of Transcription (transcription) of MR in brain associated with stress, corticosteroid and dexamethasone
3) Confidence 0.21 Published 1996 Journal Neuropsychopharmacology Section Abstract Doc Link 8946427 Disease Relevance 0.44 Pain Relevance 0.36
Exposure of hippocampal cells to 5HT for 4 days increased both glucocorticoid and mineralocorticoid receptor mRNA and protein expression.
Positive_regulation (increased) of Transcription (expression) of mineralocorticoid receptor associated with 5ht
4) Confidence 0.03 Published 2003 Journal Neuroscience Section Abstract Doc Link 12732243 Disease Relevance 0.21 Pain Relevance 0.93

General Comments

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