INT75742

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Context Info
Confidence 0.42
First Reported 1998
Last Reported 2010
Negated 4
Speculated 1
Reported most in Abstract
Documents 86
Total Number 87
Disease Relevance 95.27
Pain Relevance 19.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
legs 6
spinal 2
muscle 1
central nervous system 1
blood 1
RLS (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 60 100.00 Very High Very High Very High
Restless leg syndrome 17 100.00 Very High Very High Very High
Pain 223 99.96 Very High Very High Very High
agonist 511 99.90 Very High Very High Very High
antidepressant 62 99.90 Very High Very High Very High
headache 159 99.88 Very High Very High Very High
fluoxetine 12 99.80 Very High Very High Very High
Dopamine 561 99.72 Very High Very High Very High
depression 218 99.44 Very High Very High Very High
Neurotransmitter 14 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Restless Legs Syndrome 5343 100.00 Very High Very High Very High
Sleep Disorders 863 100.00 Very High Very High Very High
Headache 196 100.00 Very High Very High Very High
Anaemia 122 100.00 Very High Very High Very High
Cramps 45 100.00 Very High Very High Very High
Migraine Disorders 3 100.00 Very High Very High Very High
Pain 141 99.96 Very High Very High Very High
Increased Venous Pressure Under Development 55 99.92 Very High Very High Very High
Disease 524 99.84 Very High Very High Very High
Neuropathic Pain 88 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When several of our patients reported both decreased RLS-type leg restlessness and improved quality of sleep after receipt of bilateral neuroma injections for neuropathic foot pains, their observations were considered potentially significant because of the known association of late onset RLS with neuropathic foot symptoms.
RLS Binding (association) of in leg associated with akathisia, neuropathic pain, neuroma and restless legs syndrome
1) Confidence 0.42 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2949698 Disease Relevance 1.86 Pain Relevance 0.16
Secondary forms of RLS and possible interaction with other medications require particular consideration in the elderly.
RLS Binding (interaction) of associated with restless legs syndrome
2) Confidence 0.41 Published 2008 Journal Clin. Geriatr. Med. Section Abstract Doc Link 18035239 Disease Relevance 0.50 Pain Relevance 0.14
Genetic investigations have been performed in order to identify genes associated with RLS.
RLS Binding (associated) of associated with restless legs syndrome
3) Confidence 0.41 Published 2009 Journal J. Intern. Med. Section Abstract Doc Link 19817966 Disease Relevance 1.00 Pain Relevance 0.29
Overall, use of an antidepressant was associated with RLS for men (RR = 1.77, CI = 1.26, 2.48) but not for women (RR = 0.79, CI = 0.43, 1.47).
RLS Binding (associated) of associated with antidepressant and restless legs syndrome
4) Confidence 0.41 Published 2009 Journal Mov. Disord. Section Abstract Doc Link 19353713 Disease Relevance 0.59 Pain Relevance 0.39
Our data seem to confirm the existence of an association between RLS and primary headaches, particularly with migraine, as already demonstrated.
RLS Binding (association) of associated with migraine, headache and restless legs syndrome
5) Confidence 0.41 Published 2008 Journal Neurol. Sci. Section Abstract Doc Link 18545926 Disease Relevance 2.94 Pain Relevance 1.26
It is hypothesized that RLS may be associated with several somatic and neuropsychiatric symptoms.
RLS Binding (associated) of associated with restless legs syndrome
6) Confidence 0.41 Published 2001 Journal Mov. Disord. Section Abstract Doc Link 11748753 Disease Relevance 1.44 Pain Relevance 0.16
Some studies have indicated a relationship between the sleep problems associated with RLS and comorbid mood disorder (Kushida et al 2004; Hornyak et al 2005).
RLS Binding (associated) of associated with affective disorder and restless legs syndrome
7) Confidence 0.41 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671952 Disease Relevance 2.31 Pain Relevance 0.18
RLS is associated with many neurological and sleep disorders including Parkinson's disease, but does not predispose to these diseases.
RLS Binding (associated) of associated with disease, sleep disorders and restless legs syndrome
8) Confidence 0.40 Published 2008 Journal Rev. Neurol. (Paris) Section Abstract Doc Link 18656214 Disease Relevance 2.32 Pain Relevance 0.29
CONCLUSIONS: RLS is frequent in painful polyneuropathy and is significantly associated with decreased small fiber input, thus nociceptive deafferentation may represent a factor interacting with RLS "generators," possibly at spinal level.
RLS Binding (associated) of in spinal
9) Confidence 0.38 Published 2009 Journal Pain Med Section Body Doc Link 20021603 Disease Relevance 0.26 Pain Relevance 0
CONCLUSIONS: RLS is frequent in painful polyneuropathy and is significantly associated with decreased small fiber input, thus nociceptive deafferentation may represent a factor interacting with RLS "generators," possibly at spinal level.
RLS Binding (interacting) of in spinal
10) Confidence 0.38 Published 2009 Journal Pain Med Section Body Doc Link 20021603 Disease Relevance 0.23 Pain Relevance 0
The main characteristic of primary RLS is a positive family history;15 thus a genetic basis for this form has been hypothesized.16 Linkage studies demonstrated the presence of 5 different loci associated with RLS (RLS1 on chromosome 12q, RLS2 on chromosome 14q, RLS3 on chromosome 9p, RLS4 on chromosome 2q, RLS5 on chromosome 20p).17–26 A part from RLS1 that showed a pseudodominant pattern of inheritance, the remaining loci were identified under the assumption of an autosomal dominant model.
RLS1 Binding (associated) of associated with restless legs syndrome
11) Confidence 0.35 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695234 Disease Relevance 1.19 Pain Relevance 0.07
The main characteristic of primary RLS is a positive family history;15 thus a genetic basis for this form has been hypothesized.16 Linkage studies demonstrated the presence of 5 different loci associated with RLS (RLS1 on chromosome 12q, RLS2 on chromosome 14q, RLS3 on chromosome 9p, RLS4 on chromosome 2q, RLS5 on chromosome 20p).17–26 A part from RLS1 that showed a pseudodominant pattern of inheritance, the remaining loci were identified under the assumption of an autosomal dominant model.
RLS Binding (associated) of associated with restless legs syndrome
12) Confidence 0.35 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695234 Disease Relevance 1.19 Pain Relevance 0.07
Although the etiopathogenesis of RLS is still unknown, the rapid and dramatic improvement of RLS with dopaminergic agents suggests that dopaminergic system dysfunction may be a basic mechanism.
RLS Binding (improvement) of associated with restless legs syndrome
13) Confidence 0.32 Published 2009 Journal Expert Opin Pharmacother Section Abstract Doc Link 19284359 Disease Relevance 0.54 Pain Relevance 0.09
Many pathogenetic considerations about links between RLS and primary headaches could be given, the most fitting involving dopamine and melatonin.
RLS Binding (links) of associated with dopamine, headache and restless legs syndrome
14) Confidence 0.32 Published 2008 Journal Neurol. Sci. Section Abstract Doc Link 18545926 Disease Relevance 2.44 Pain Relevance 0.99
Analyses of individual antidepressants revealed an association between RLS and fluoxetine for women (RR = 2.47, CI = 1.33, 4.56), and associations between RLS and citalopram, (RR = 2.09, CI = 1.20, 3.64), paroxetine (RR = 1.97, CI = 1.02, 3.79), and amitriptyline (RR = 2.40, CI = 1.45, 4.00) for men.
RLS Binding (association) of associated with antidepressant, restless legs syndrome, endep and fluoxetine
15) Confidence 0.32 Published 2009 Journal Mov. Disord. Section Abstract Doc Link 19353713 Disease Relevance 0.61 Pain Relevance 0.43
Inconsistent with the hypothesis that RLS and 'growing pains' are the same are the high association of 'growing pains' with migraine headaches and abdominal pain.
RLS Binding (association) of associated with abdominal pain, migraine, headache and restless legs syndrome
16) Confidence 0.32 Published 2002 Journal Sleep Med. Section Abstract Doc Link 14592226 Disease Relevance 1.24 Pain Relevance 0.53
Analyses of individual antidepressants revealed an association between RLS and fluoxetine for women (RR = 2.47, CI = 1.33, 4.56), and associations between RLS and citalopram, (RR = 2.09, CI = 1.20, 3.64), paroxetine (RR = 1.97, CI = 1.02, 3.79), and amitriptyline (RR = 2.40, CI = 1.45, 4.00) for men.
RLS Binding (associations) of associated with antidepressant, restless legs syndrome, endep and fluoxetine
17) Confidence 0.32 Published 2009 Journal Mov. Disord. Section Abstract Doc Link 19353713 Disease Relevance 0.61 Pain Relevance 0.44
Four symptom questions accepted as minimal diagnostic criteria for RLS were also included.
RLS Binding (criteria) of associated with restless legs syndrome
18) Confidence 0.32 Published 2001 Journal Mov. Disord. Section Abstract Doc Link 11748753 Disease Relevance 1.31 Pain Relevance 0.15
Antidepressant medications frequently precipitate or worsen the condition of RLS.
RLS Binding (condition) of associated with antidepressant and restless legs syndrome
19) Confidence 0.32 Published 2001 Journal Spinal Cord Section Abstract Doc Link 11326321 Disease Relevance 0.83 Pain Relevance 0.35
Leg cramps may be differentiated from RLS in that the cramps typically affect specific muscle groups (eg, gastrocnemius), may be unilateral, can be associated with strenuous exercise and electrolyte imbalance, and may not temporarily be relieved by leg movement.
RLS Binding (affect) of in muscle associated with cramps and restless legs syndrome
20) Confidence 0.32 Published 2006 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2671939 Disease Relevance 1.42 Pain Relevance 0.05

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