INT75768

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Context Info
Confidence 0.27
First Reported 1998
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 37
Total Number 38
Disease Relevance 19.41
Pain Relevance 9.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
liver 4
spleen 3
spinal cord 1
brain 1
microglia 1
Cpox (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 341 100.00 Very High Very High Very High
cytokine 255 100.00 Very High Very High Very High
COX-2 inhibitor 74 100.00 Very High Very High Very High
Spinal cord 13 99.28 Very High Very High Very High
Arthritis 16 96.16 Very High Very High Very High
cINOD 255 95.56 Very High Very High Very High
agonist 11 94.44 High High
Lasting pain 12 93.76 High High
Inflammatory stimuli 11 93.76 High High
dexamethasone 7 93.04 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 469 100.00 Very High Very High Very High
Carcinoma 21 99.08 Very High Very High Very High
Hemophilus Infection 89 98.66 Very High Very High Very High
Pancreatic Cancer 84 98.24 Very High Very High Very High
Injury 99 97.28 Very High Very High Very High
Adenoma 28 97.00 Very High Very High Very High
Cancer 218 96.52 Very High Very High Very High
Arthritis 16 96.16 Very High Very High Very High
Infection 21 95.52 Very High Very High Very High
Targeted Disruption 178 95.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For purposes of comparison, COX-1v mRNA was also expressed in heart, brain, spinal cord, kidney, spleen and skin.
Transcription (expressed) of COX in spleen associated with spinal cord
1) Confidence 0.27 Published 2004 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 15560114 Disease Relevance 0.64 Pain Relevance 0.77
In the peritoneal cells, the mRNA expression for the constitutive cyclooxygenase-1 (COX-1) was unchanged by PQ administration.
Transcription (expression) of COX
2) Confidence 0.25 Published 1998 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 9661217 Disease Relevance 0.07 Pain Relevance 0.04
Although previously characterized alterations in gene and protein expression in COX-deficient mice have been examined, they were discovered in a 'one protein and one gene at a time fashion' using Western blotting and real-time polymerase chain reaction (PCR) [5-7].
Transcription (expression) of COX
3) Confidence 0.25 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.34 Pain Relevance 0
By RT-PCR, both cyclooxygenase (COX)-1 and COX-2 mRNAs are detected in NCI-H157 and H1264 cells.
Transcription (detected) of COX
4) Confidence 0.25 Published 1998 Journal Anticancer Res. Section Abstract Doc Link 9615719 Disease Relevance 0.76 Pain Relevance 0.31
In contrast, little mRNA for COX-2 was detected in the peritoneal cells from unstimulated animals, and was induced 60-120 min. after PQ administration.
Transcription (detected) of COX
5) Confidence 0.24 Published 1998 Journal Prostaglandins Other Lipid Mediat. Section Abstract Doc Link 9661217 Disease Relevance 0.08 Pain Relevance 0.04
Increased PGE2 production has been shown to be mainly due to an increase in COX activity, which is, in turn, due to an increase in COX-2 protein and mRNA expression.
Transcription (expression) of COX
6) Confidence 0.22 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 15331118 Disease Relevance 0.41 Pain Relevance 0.10
0.9) and strongly negatively correlated with the number of Mac-1-stained reactive microglia and with the level of COX-2 (rs ?
Transcription (level) of COX in microglia
7) Confidence 0.22 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.17 Pain Relevance 0.20
From the COX-2 inhibitor study (Fig. 5C &5D), the number of TH-positive neurons was strongly positively correlated with the number of Nissl-stained neurons and the amount of the COX-2 inhibitor administered per day (rs ?
Transcription (amount) of COX in neurons associated with cox-2 inhibitor
8) Confidence 0.22 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1440849 Disease Relevance 0.27 Pain Relevance 0.13
By RT-PCR, both cyclooxygenase (COX)-1 and COX-2 mRNAs are detected in NCI-H157 and H1264 cells.
Transcription (detected) of COX
9) Confidence 0.22 Published 1998 Journal Anticancer Res. Section Abstract Doc Link 9615719 Disease Relevance 0.76 Pain Relevance 0.31
Elevated COX-2 mRNA represents a higher transcription rate rather than an altered stability of COX-2 mRNA.
Transcription (transcription) of COX
10) Confidence 0.21 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 15331118 Disease Relevance 0.40 Pain Relevance 0.10
Ceramide up-regulates COX-2 transcription by increasing activation of transcription factor NF-kappaB.
Transcription (transcription) of COX
11) Confidence 0.19 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 15331118 Disease Relevance 0.16 Pain Relevance 0.05
Parthenolide's effects on specific cytokine gene expression have been documented in vitro, but, to our knowledge, few data are available regarding effects on mRNA expression of cytokines or other inflammatory genes such as COX-2 in vivo.
Transcription (expression) of COX associated with inflammation and cytokine
12) Confidence 0.16 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1185559 Disease Relevance 0.32 Pain Relevance 0.34
One explanation for the variation of COX expression is the short half-life of COX-2 transcripts or individual variability of inflammatory-related processes.
Transcription (transcripts) of COX associated with inflammation
13) Confidence 0.14 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2925207 Disease Relevance 0.80 Pain Relevance 0.39
In addition, it could be that the compound, even though it is the R enantiomer of flurbiprofen, still maintains a significant anti-COX activity at the high dose used in the study (800?
Transcription (activity) of anti-COX
14) Confidence 0.14 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912027 Disease Relevance 0.65 Pain Relevance 0.38
Cyclooxygenase (COX), the key regulatory enzyme for prostaglandin synthesis, is transcribed from two distinct genes.
Transcription (transcribed) of COX
15) Confidence 0.13 Published 1999 Journal Expert Opin Investig Drugs Section Abstract Doc Link 15992053 Disease Relevance 0.28 Pain Relevance 0.15
Cyclooxygenase (COX), the key regulatory enzyme for prostaglandin synthesis is transcribed from two distinct genes.
Transcription (transcribed) of COX
16) Confidence 0.13 Published 1999 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10668484 Disease Relevance 0.28 Pain Relevance 0.15
The transcription of COX, the target pathway in mammalian models, was only weakly affected by ibuprofen, restricting possible conclusions regarding whether ibuprofen is a COX inhibitor in daphnids until more (proteomic) evidence is available.
Transcription (transcription) of COX
17) Confidence 0.13 Published 2008 Journal Genome Biol Section Body Doc Link PMC2374704 Disease Relevance 0.17 Pain Relevance 0.19
Overall, COX-2 mRNA expression levels were 15.6- and 14.2-fold higher in spleen of LPS-treated mice and parthenolide plus LPS-treated mice, respectively, when compared to expression levels observed in liver.


Transcription (expression) of COX in liver
18) Confidence 0.12 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1185559 Disease Relevance 0.15 Pain Relevance 0.07
COX-2 mRNA expression was markedly induced in the spleen of LPS treated animals (44.8 ± 5.0-fold over control) and increased to a lesser extent in liver (4.6 ± 0.9) (Fig. 6).
Transcription (expression) of COX in liver
19) Confidence 0.12 Published 2005 Journal J Inflamm (Lond) Section Body Doc Link PMC1185559 Disease Relevance 0.05 Pain Relevance 0.03
B, cAMP, and CREB) that either enhance or suppress COX-2 transcription [171, 172].
Transcription (transcription) of COX
20) Confidence 0.12 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.59 Pain Relevance 0.38

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