INT7577

Context Info Confidence 0.56 First Reported 1982 Last Reported 2008 Negated 4 Speculated 4 Reported most in Abstract Documents 16 Total Number 25 Disease Relevance 7.70 Pain Relevance 10.10

endoplasmic reticulum (Nr3c2) nucleus (Nr3c2) cytoplasm (Nr3c2)

Anatomy Link Frequency dentate gyrus 2 neurons 2 hippocampus 2 Nr3c2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Hippocampus 209 100.00 Morphine 37 100.00 fluoxetine 7 100.00 agonist 5 100.00 GABAergic 1 100.00 Neurotransmitter 7 99.48 narcan 10 99.46 excitatory amino acid 8 99.00 amygdala 2 98.16 Neuronal excitability 7 97.68

Disease Link Frequency Relevance Heat Nociception 2 99.28 Stress 389 99.24 Opiate Addiction 8 96.80 Disease 14 94.48 Post-traumatic Stress Disorder 189 90.20 Pain 2 89.60 Attention Deficit Hyperactivity Disorder 5 88.44 Congenital Anomalies 7 87.36 Decapitation 7 80.24 Depression 19 77.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, the present study demonstrates that: (1) prenatal stress due to maternal saline injections alters MR and GR binding of adult male and female rats and is prevented by prenatal morphine exposure; (2) the MR and GR binding in adult female rats are affected by ovarian hormone fluctuations.

Regulation (affected) of MR associated with stress and morphine

1) Confidence 0.56 Published 2006 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 16698219 Disease Relevance 0.38 Pain Relevance 0.69

Dysregulation of MR/GR balance brings CA1 neurons into a vulnerable state with consequences for regulation of the stress response and enhanced vulnerability to disease in genetically predisposed individuals.

Regulation (Dysregulation) of MR/GR in neurons associated with stress and disease

2) Confidence 0.43 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.95 Pain Relevance 0.38

It is concluded that MR GABAergic systems, via their influence on MR 5-HT cells, serve an important role in the control of the hippocampal EEG.

Regulation (influence) of MR associated with gabaergic

3) Confidence 0.39 Published 1995 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 8524970 Disease Relevance 0 Pain Relevance 0.19

The effects of prenatal morphine exposure (E11-18) on mineralocorticoid receptor (MR) modulation of synaptic plasticity were investigated in the lateral perforant path (LPP)-dentate gyrus granule cell synaptic system.

Spec (investigated) Regulation (effects) of MR in dentate gyrus associated with morphine

4) Confidence 0.38 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 14519453 Disease Relevance 0.08 Pain Relevance 0.36

The effects of prenatal morphine exposure (E11-18) on mineralocorticoid receptor (MR) modulation of synaptic plasticity were investigated in the lateral perforant path (LPP)-dentate gyrus granule cell synaptic system.

Spec (investigated) Regulation (effects) of mineralocorticoid receptor in dentate gyrus associated with morphine

5) Confidence 0.38 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 14519453 Disease Relevance 0.08 Pain Relevance 0.36

Figure 3 showed a significant down-regulation of hippocampal MR and GR protein in SPS rats in comparison with control rats (p<0.05).

Regulation (regulation) of MR associated with stress

6) Confidence 0.38 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.81 Pain Relevance 0.20

The second is down-regulation of MR and unaltered GR [23].

Regulation (regulation) of MR

7) Confidence 0.38 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.56 Pain Relevance 0.07

The third is down-regulation of MR and up-regulation of GR [15].

Regulation (regulation) of MR

8) Confidence 0.38 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.53 Pain Relevance 0.07

Studies have demonstrated that long-term changes in 5-HT levels are associated with alterations in hippocampal glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) number.

Regulation (alterations) of mineralocorticoid receptor

9) Confidence 0.37 Published 1995 Journal Brain Res. Section Abstract Doc Link 7583200 Disease Relevance 0 Pain Relevance 0.30

Studies have demonstrated that long-term changes in 5-HT levels are associated with alterations in hippocampal glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) number.

Regulation (alterations) of MR

10) Confidence 0.37 Published 1995 Journal Brain Res. Section Abstract Doc Link 7583200 Disease Relevance 0 Pain Relevance 0.30

Selective effects on NGFI-A, MR, GR and NGFI-B hippocampal mRNA expression after chronic treatment with different subclasses of antidepressants in the rat.

Regulation (effects) of MR associated with antidepressant

11) Confidence 0.36 Published 2000 Journal Psychopharmacology (Berl.) Section Title Doc Link 10958110 Disease Relevance 0 Pain Relevance 0.27

PCA produced an 87% decrease in hippocampal 5-HT and 5-HIAA levels, but did not alter hippocampal GR or MR levels.

Neg (not) Regulation (alter) of MR

12) Confidence 0.27 Published 1995 Journal Brain Res. Section Abstract Doc Link 7583200 Disease Relevance 0 Pain Relevance 0.26

The above data strongly suggest that GR and MR may be affected by some psychotropic drugs which are known to cause alterations in classic neurotransmitter systems.

Regulation (affected) of MR associated with neurotransmitter

13) Confidence 0.25 Published 1994 Journal Pol J Pharmacol Section Abstract Doc Link 8000453 Disease Relevance 0.06 Pain Relevance 0.52

A similar facilitation of the effect of morphine was observed upon exposure of the neurons to relatively high (nanomolar) concentrations of corticosterone, whereas the mineralocorticoid receptor agonist aldosterone appeared to be ineffective in this respect, indicating the involvement of glucocorticoid receptors.

Regulation (ineffective) of mineralocorticoid receptor in neurons associated with agonist and morphine

14) Confidence 0.23 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562482 Disease Relevance 0 Pain Relevance 0.96

The present findings indicate EAA afferents to the MR normally exert an excitatory influence on the MR in its desynchronization of the hippocampal EEG, whereas the removal of EAA inputs to MR produces the opposite: a reduction of MR activity and hence the elicitation of theta.

Regulation (influence) of MR associated with excitatory amino acid

15) Confidence 0.23 Published 1994 Journal Brain Res. Section Abstract Doc Link 7982102 Disease Relevance 0 Pain Relevance 0.60

Immunohistochemistry revealed decreased MR- and GR-immunoreactivity (ir) in the CA1 of hippocampus in SPS animals.

Regulation (immunoreactivity) of MR in hippocampus associated with stress and hippocampus

16) Confidence 0.23 Published 2008 Journal Acta Histochemica et Cytochemica Section Abstract Doc Link PMC2532603 Disease Relevance 1.41 Pain Relevance 0.13

The change in MR-ir was more conspicuous than that in GR-ir.

Regulation (change) of MR

17) Confidence 0.23 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.49 Pain Relevance 0.04

A number of studies examined the importance of hippocampal MR in controlling HPA axis.

Spec (examined) Regulation (importance) of MR

18) Confidence 0.23 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 0.64 Pain Relevance 0.25

No consistent change in steroid hormone receptor mRNA levels was seen in the hippocampus with the 3 drugs, but fluoxetine and idazoxan increased the level of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) mRNA, respectively, after 8 weeks of drug administration.

Neg (No) Regulation (change) of mineralocorticoid receptor in hippocampus associated with hippocampus and fluoxetine

19) Confidence 0.21 Published 1992 Journal Brain Res. Section Abstract Doc Link 1351783 Disease Relevance 0.43 Pain Relevance 0.67

By contrast, neither chronic morphine exposure nor injection of naloxone in morphine naive animals affected GR or MR mRNA levels.

Neg (nor) Regulation (affected) of MR mRNA associated with narcan and morphine

20) Confidence 0.19 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 14559365 Disease Relevance 0.25 Pain Relevance 1.22

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