INT75773

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.78
First Reported 1998
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 12
Total Number 15
Disease Relevance 1.75
Pain Relevance 3.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (UGT1A3) enzyme binding (UGT1A3)
Anatomy Link Frequency
hepatocytes 1
liver 1
embryonic kidney 1
UGT1A3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Buprenorphine 25 99.96 Very High Very High Very High
Opioid 11 98.64 Very High Very High Very High
Morphine 12 98.08 Very High Very High Very High
Bile 39 97.24 Very High Very High Very High
cINOD 12 91.84 High High
Inflammation 12 88.88 High High
Catecholamine 6 79.88 Quite High
agonist 52 5.00 Very Low Very Low Very Low
Kinase C 16 5.00 Very Low Very Low Very Low
Paracetamol 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Van Bogaert's Disease 28 98.80 Very High Very High Very High
Targeted Disruption 8 92.72 High High
INFLAMMATION 16 88.88 High High
Colon Cancer 1 88.80 High High
Obesity 4 8.80 Low Low
Toxicity 9 5.00 Very Low Very Low Very Low
Gallstones 8 5.00 Very Low Very Low Very Low
Sprains And Strains 8 5.00 Very Low Very Low Very Low
Syndrome 8 5.00 Very Low Very Low Very Low
Insulin Resistance 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, compounds containing an aliphatic hydroxyl group, such as sapogenins, monoterpenoid alcohols (e.g. menthol and borneol), and androgens, were not conjugated by expressed human UGT1A3.
Neg (not) Gene_expression (expressed) of UGT1A3
1) Confidence 0.78 Published 1998 Journal Drug Metab. Dispos. Section Abstract Doc Link 9616184 Disease Relevance 0.09 Pain Relevance 0.28
We show that human UGT1A3, transiently expressed in human embryonic kidney 293 cells, also catalyzes the N-glucuronidation of primary, secondary, and tertiary amine substrates, such as 4-aminobiphenyl, diphenylamine, and cyproheptadine.
Gene_expression (expressed) of UGT1A3 in embryonic kidney
2) Confidence 0.78 Published 1998 Journal Drug Metab. Dispos. Section Abstract Doc Link 9616184 Disease Relevance 0 Pain Relevance 0
The present study was designed to study the kinetic interaction of expressed human UGT2B7(Y) or (H), UGT1A1, and UGT1A3 toward 2- and 4-hydroxycatechol estrogens. cDNAs encoding UGT2B7(Y) or (H), UGT1A1, and UGT1A3 were expressed in HK293 cells, and cell homogenates or membrane preparations were used to determine their glucuronidation ability.
Gene_expression (expressed) of UGT1A3
3) Confidence 0.75 Published 1998 Journal Toxicol. Sci. Section Abstract Doc Link 9848110 Disease Relevance 0 Pain Relevance 0.26
RT-PCR analysis demonstrated that the UGT1A isoforms, UGT1A3, 1A8, and 1A10, and UGT2B7 were expressed in the GI tract.
Gene_expression (expressed) of UGT1A3
4) Confidence 0.75 Published 2004 Journal Biochim. Biophys. Acta Section Abstract Doc Link 15535975 Disease Relevance 0.15 Pain Relevance 0.64
In addition to amines, expressed human UGT1A3 catalyzed the glucuronidation of opioids (e.g. morphine and buprenorphine), coumarins, flavonoids (e.g. naringenin and quercetin), anthraquinones, and small phenolic compounds (e.g. 4-nitrophenol).
Gene_expression (expressed) of UGT1A3 associated with opioid, buprenorphine and morphine
5) Confidence 0.68 Published 1998 Journal Drug Metab. Dispos. Section Abstract Doc Link 9616184 Disease Relevance 0.08 Pain Relevance 0.33
The reactivity of expressed human UGT1A3 toward hydroxylated and carboxylic acid-containing compounds was also examined.
Gene_expression (expressed) of UGT1A3
6) Confidence 0.68 Published 1998 Journal Drug Metab. Dispos. Section Abstract Doc Link 9616184 Disease Relevance 0.07 Pain Relevance 0.29
RT-PCR experiments indicated that the PD-7 and TC-7 clones expressed the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6, UGT1A3 and UGT2B7, which could account for the glucuronidation of phenols and carboxylic acids observed.
Gene_expression (expressed) of UGT1A3
7) Confidence 0.64 Published 2000 Journal Life Sci. Section Abstract Doc Link 10901286 Disease Relevance 0.25 Pain Relevance 0.25
Among the six hepatic UGT isoforms tested, UGT1A1, UGT1A3, and UGT2B7 metabolized BUP and Nor-BUP.
Neg (Nor) Gene_expression (metabolized) of UGT1A3 associated with buprenorphine
8) Confidence 0.58 Published 2010 Journal Drug Metab. Dispos. Section Abstract Doc Link 19841060 Disease Relevance 0 Pain Relevance 0.99
Glucuronidation of 1'-HE was not detected in cells expressing UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A7, UGT1A8, and UGT1A10. 1'-HE glucuronidation in 27 individual human liver samples significantly (p < 0.05) correlated with the glucuronidation of other UGT2B7 substrates (morphine and ibuprofen).
Gene_expression (expressing) of UGT1A3 in liver associated with morphine
9) Confidence 0.56 Published 2003 Journal Toxicol. Sci. Section Abstract Doc Link 12657745 Disease Relevance 0 Pain Relevance 0.09
The present study was designed to study the kinetic interaction of expressed human UGT2B7(Y) or (H), UGT1A1, and UGT1A3 toward 2- and 4-hydroxycatechol estrogens. cDNAs encoding UGT2B7(Y) or (H), UGT1A1, and UGT1A3 were expressed in HK293 cells, and cell homogenates or membrane preparations were used to determine their glucuronidation ability.
Gene_expression (expressed) of UGT1A3
10) Confidence 0.51 Published 1998 Journal Toxicol. Sci. Section Abstract Doc Link 9848110 Disease Relevance 0 Pain Relevance 0.26
The present study was designed to study the kinetic interaction of expressed human UGT2B7(Y) or (H), UGT1A1, and UGT1A3 toward 2- and 4-hydroxycatechol estrogens. cDNAs encoding UGT2B7(Y) or (H), UGT1A1, and UGT1A3 were expressed in HK293 cells, and cell homogenates or membrane preparations were used to determine their glucuronidation ability.
Gene_expression (expressed) of UGT1A3
11) Confidence 0.51 Published 1998 Journal Toxicol. Sci. Section Abstract Doc Link 9848110 Disease Relevance 0 Pain Relevance 0.15
increased the expression of UGT1A3 and UGT1A3-catalyzed glucuronidation of chenodeoxycholic acid (CDCA) and demonstrably tempered the transactivation of FXR by CDCA [99].
Gene_expression (expression) of UGT1A3 associated with van bogaert's disease
12) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.36 Pain Relevance 0
increased the expression of UGT1A3 and UGT1A3-catalyzed glucuronidation of chenodeoxycholic acid (CDCA) and demonstrably tempered the transactivation of FXR by CDCA [99].
Gene_expression (expression) of UGT1A3 associated with van bogaert's disease
13) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.35 Pain Relevance 0
-flanking regions of UGT1A1, UGT1A3 and UGT1A6 [125] (Figure 2).
Gene_expression (regions) of UGT1A3
14) Confidence 0.30 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.31 Pain Relevance 0
In a recent study by Senekeo-Effenberger et al. [125], Wy-14,643 treatment of primary cultured human hepatocytes increased the levels of UGT1A1, UGT1A3, UGT1A4, and UGT1A6, but not UGT1A9, mRNAs.
Gene_expression (levels) of UGT1A3 in hepatocytes
15) Confidence 0.27 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0.09 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox