INT7578

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Context Info
Confidence 0.32
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.43
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Nr3c1) intracellular (Nr3c1) DNA binding (Nr3c1)
protein complex (Nr3c1) cytoplasm (Nr3c1) cytosol (Nr3c1)
Anatomy Link Frequency
plasma 1
neuronal 1
lamina 1
hippocampus 1
Nr3c1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 3 99.68 Very High Very High Very High
fluoxetine 6 99.44 Very High Very High Very High
Hippocampus 3 98.78 Very High Very High Very High
Opioid 1 93.00 High High
antidepressant 8 92.96 High High
corticosteroid 3 85.32 High High
Locus ceruleus 1 84.64 Quite High
monoamine 1 80.08 Quite High
antagonist 2 78.48 Quite High
depression 3 71.84 Quite High
Disease Link Frequency Relevance Heat
Depression 5 71.84 Quite High
Stress 37 68.80 Quite High
Hyperphagia 1 53.12 Quite High
Sleep Disorders 1 52.44 Quite High
INFLAMMATION 4 46.64 Quite Low
Body Weight 1 20.80 Low Low
Endometriosis (extended) 11 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 3 5.00 Very Low Very Low Very Low
Reprotox - General 1 3 5.00 Very Low Very Low Very Low
Hypoactive Sexual Desire Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the effects of short term (9 days) treatment with fluoxetine (10 mg/kg) and venlafaxine (10 mg/kg) on hippocampal mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) mRNA expression and spatial memory in adult rats.
Transcription (expression) of glucocorticoid receptor associated with fluoxetine
1) Confidence 0.32 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11406320 Disease Relevance 0 Pain Relevance 0.58
Glucocorticoid receptor expression was absent in crypts and the lamina propria.
Neg (absent) Transcription (absent) of Glucocorticoid receptor in lamina
2) Confidence 0.29 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532488 Disease Relevance 0 Pain Relevance 0
No consistent change in steroid hormone receptor mRNA levels was seen in the hippocampus with the 3 drugs, but fluoxetine and idazoxan increased the level of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) mRNA, respectively, after 8 weeks of drug administration.
Transcription (level) of glucocorticoid receptor in hippocampus associated with hippocampus and fluoxetine
3) Confidence 0.26 Published 1992 Journal Brain Res. Section Abstract Doc Link 1351783 Disease Relevance 0.30 Pain Relevance 0.61
Mid-luteal phase women also display reduced sensitivity to glucocorticoid feedback (lower suppression of plasma cortisol in response to a low dose of synthetic glucocorticoid dexamethasone) and decreased glucocorticoid receptor (type II) mRNA expression in lymphocytes compared to women in the early follicular phase [45].
Transcription (expression) of glucocorticoid receptor in plasma associated with dexamethasone
4) Confidence 0.07 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2890612 Disease Relevance 0.14 Pain Relevance 0.18
Measurements of basal release and content of AVP in the hypothalamus following long-term ADX and CB treatment revealed that AVP neuronal activity is also subject to manipulations of the glucocorticoid hormone environment.
Transcription (manipulations) of glucocorticoid hormone in neuronal
5) Confidence 0.04 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1766548 Disease Relevance 0 Pain Relevance 0.09

General Comments

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