INT75800

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Context Info
Confidence 0.77
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 16
Disease Relevance 5.15
Pain Relevance 5.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp2a5)
Anatomy Link Frequency
astrocytes 2
LNG 2
liver 1
lateral 1
olfactory mucosa 1
Cyp2a5 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 115 99.38 Very High Very High Very High
Paracetamol 73 98.60 Very High Very High Very High
Hippocampus 45 93.96 High High
nMDA receptor 65 90.56 High High
agonist 45 89.84 High High
medulla 25 85.12 High High
Bile 6 79.52 Quite High
antagonist 30 72.68 Quite High
ASIC 20 65.92 Quite High
Analgesic 1 60.96 Quite High
Disease Link Frequency Relevance Heat
Toxicity 31 98.78 Very High Very High Very High
Hepatotoxicity 6 98.04 Very High Very High Very High
Injury 22 97.32 Very High Very High Very High
Targeted Disruption 62 97.20 Very High Very High Very High
Stress 110 96.72 Very High Very High Very High
Infection 187 93.20 High High
Embryonic Lethality 4 87.12 High High
Hepatitis 3 83.88 Quite High
Malaria 135 77.08 Quite High
Nash(non-alcoholic Steatohepatitis) 7 76.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The metabolic activation of two known olfactory mucosal (OM) toxicants, acetaminophen (AP) and 2,6-dichlorobenzonitrile (DCBN), was examined with mouse liver and OM microsomes and purified, heterologously expressed mouse CYP2A5 and CYP2G1.
Gene_expression (expressed) of CYP2A5 in liver associated with paracetamol
1) Confidence 0.77 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9618435 Disease Relevance 0 Pain Relevance 0.75
We found that heterologously expressed mouse CYP2A5 and CYP2G1 enzymes (known to be present in olfactory mucosa) form 3-hydroxyacetaminophen (3-OH-AP) and 3-(glutathion-S-yl)acetaminophen (GS-AP); CYP2A5 is considerably more active than 2G1.
Gene_expression (expressed) of CYP2A5 in olfactory mucosa associated with paracetamol
2) Confidence 0.76 Published 1998 Journal Biochem. Pharmacol. Section Abstract Doc Link 9714300 Disease Relevance 0.54 Pain Relevance 1.16
The loss of CYP2G1 expression, and the associated decrease in the hepatic expression of CYP2A5, did not decrease systemic clearance, extent of hepatotoxicity, or OM toxicity of acetaminophen (AP).
Gene_expression (expression) of CYP2A5 associated with toxicity, paracetamol and hepatotoxicity
3) Confidence 0.73 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14610229 Disease Relevance 0.58 Pain Relevance 0.43
Targeted disruption of the olfactory mucosa-specific Cyp2g1 gene: impact on acetaminophen toxicity in the lateral nasal gland, and tissue-selective effects on Cyp2a5 expression.
Gene_expression (expression) of Cyp2a5 in gland associated with targeted disruption, toxicity and paracetamol
4) Confidence 0.73 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 14610229 Disease Relevance 0.54 Pain Relevance 0.27
Unexpectedly, a significant reduction in the expression of the Cyp2a5 gene was found in the liver, the lateral nasal gland (LNG), and, to a lesser extent, the kidney of adult Cyp2g1-null mice.
Gene_expression (expression) of Cyp2a5 in lateral
5) Confidence 0.73 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14610229 Disease Relevance 0.54 Pain Relevance 0.35
Paradoxically, the LNG did not have detectable CYP2G1, and the decrease in LNG CYP2A5 expression in the Cyp2g1-null mice was not accompanied by decreases in microsomal AP metabolism.
Gene_expression (expression) of LNG CYP2A5 in LNG associated with paracetamol
6) Confidence 0.64 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14610229 Disease Relevance 0.55 Pain Relevance 0.45
The expression of CYP2a5 in a glucose-6-phosphate dehydrogenase (G6PD)-deficient mouse model of oxidative stress was studied by Nichols and Kirby [42].
Gene_expression (expression) of CYP2a5 associated with stress
7) Confidence 0.63 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 1.05 Pain Relevance 0
Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes.
Gene_expression (expressed) of CYP2A5 in olfactory associated with paracetamol
8) Confidence 0.60 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9618435 Disease Relevance 0 Pain Relevance 0.85
Moreover, the authors pointed out that the foregoing CYP2a5 inducers also up-regulated HO-1, and that CYP2a5 over-expression is often associated with a decrease of total CYP content, which in turn has been shown to be associated with HO-1 induction as well.
Gene_expression (expression) of CYP2a5
9) Confidence 0.49 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.35 Pain Relevance 0.04
A hypothesis was advanced that a coordinated regulation of CYP2a5 and HO-1 expressions contributes to achieving a balance between bilirubin production and elimination.
Gene_expression (expressions) of CYP2a5
10) Confidence 0.49 Published 2010 Journal Malar J Section Body Doc Link PMC2858213 Disease Relevance 0.35 Pain Relevance 0.04
Most importantly, fine astrocytic processes were located at the apposition zone of the finger-like stalks of the CoH and the PPNs (Fig. 2, D and F).
Gene_expression (stalks) of CoH in finger
11) Confidence 0.30 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888059 Disease Relevance 0.08 Pain Relevance 0.03
Synaptic activity in the CoH synapse does not elicit uptake currents in astrocytes
Gene_expression (synapse) of CoH in astrocytes
12) Confidence 0.30 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888059 Disease Relevance 0 Pain Relevance 0.40
Overall, we conclude that gliotransmission through astrocytes occurs at the CoH synapse.
Gene_expression (synapse) of CoH in synapse
13) Confidence 0.30 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888059 Disease Relevance 0 Pain Relevance 0.32
Immunocytochemical and electron microscopy studies showed glutamate aspartate transporter (GLAST) expression in glial processes contacting PPN and CoH (Renden et al., 2005).
Gene_expression (expression) of CoH associated with glutamate
14) Confidence 0.30 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888059 Disease Relevance 0 Pain Relevance 0.29
By inspecting either glial cells with passive membrane currents or eGFP-labeled astrocytes, we found that the cell somata can be in very close contact to the CoH synapse (Fig. 1 A; Fig. 2, A and B), sometimes completely ensheathing the CoH (Video 1), and that a given astrocyte contacted several PPNs with its processes.


Gene_expression (synapse) of CoH in astrocytes
15) Confidence 0.30 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2888059 Disease Relevance 0.13 Pain Relevance 0
Moreover, Cyp2e5 overexpression spacially coincides with MDB formation (Zatloukal et al., unpublished data).
Gene_expression (overexpression) of Cyp2e5
16) Confidence 0.01 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.44 Pain Relevance 0

General Comments

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