INT75803

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Context Info
Confidence 0.43
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.13
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp2a5)
Cyp2a5 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 14 98.48 Very High Very High Very High
Potency 5 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
antidepressant 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 1 72.32 Quite High
Fever 18 61.96 Quite High
Anxiety Disorder 11 5.00 Very Low Very Low Very Low
Stress 10 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OM microsomal AP and DCBN metabolic activation was inhibited by 5- and 8-methoxsalen, which inhibit both CYP2A5 and CYP2G1, and by an inhibitory anti-CYP2A5 antibody that also inhibits CYP2G1.
Negative_regulation (inhibit) of CYP2A5 associated with paracetamol
1) Confidence 0.43 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9618435 Disease Relevance 0.07 Pain Relevance 1.08
The resulting fragments (Fig. 2c) showed the loss of a hydroxyl (corresponding to a N-oxide benzodiazepine), a –COH (corresponding to a benzodiazepine with carbonyl group) and a phenyl group.
Negative_regulation (loss) of COH
2) Confidence 0.05 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2813522 Disease Relevance 0.06 Pain Relevance 0

General Comments

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