INT75815

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Context Info
Confidence 0.40
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 12
Disease Relevance 5.10
Pain Relevance 3.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE2A) signal transduction (PDE2A) Golgi apparatus (PDE2A)
endoplasmic reticulum (PDE2A) plasma membrane (PDE2A) nucleus (PDE2A)
Anatomy Link Frequency
neuronal 2
brain 2
colon 1
PDE2A (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 90 100.00 Very High Very High Very High
Opioid 18 99.98 Very High Very High Very High
MU agonist 3 99.92 Very High Very High Very High
Glutamate 117 99.80 Very High Very High Very High
Immobilon 3 99.52 Very High Very High Very High
agonist 7 97.24 Very High Very High Very High
cytokine 15 90.84 High High
cINOD 5 90.44 High High
5HT 39 87.60 High High
adenocard 3 86.48 High High
Disease Link Frequency Relevance Heat
Colon Cancer 21 99.68 Very High Very High Very High
Death 11 97.72 Very High Very High Very High
Apoptosis 13 96.36 Very High Very High Very High
Solid Tumor 4 96.04 Very High Very High Very High
Neuroblastoma 6 94.80 High High
Stress 246 93.80 High High
Anxiety Disorder 66 93.36 High High
Cancer 6 90.88 High High
Glioma 3 90.80 High High
INFLAMMATION 11 90.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reexamination of opioid stimulation of cGMP formation in cell lines of neuronal origin.
Positive_regulation (stimulation) of cGMP in neuronal associated with opioid and immobilon
1) Confidence 0.40 Published 1998 Journal Cell. Mol. Neurobiol. Section Title Doc Link 9619297 Disease Relevance 0.25 Pain Relevance 0.64
The nitric oxide donor nitroprusside elevated cGMP in both cell lines. 3.
Positive_regulation (elevated) of cGMP
2) Confidence 0.40 Published 1998 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 9619297 Disease Relevance 0.27 Pain Relevance 0.61
The effect of opioid agonists on cGMP accumulation in two cell lines of neuronal origin was measured.
Positive_regulation (accumulation) of cGMP in neuronal associated with mu agonist
3) Confidence 0.40 Published 1998 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 9619297 Disease Relevance 0.26 Pain Relevance 0.56
Long-term DETA NONOate administration induced an immediate mRNA up-regulation of PDE5A (1.9-fold, 0.5 hour), an early peak of PDE2A (1.4-fold, 1 and 2 hours) and later up-regulation of both PDE3B (1.6-fold, 4 hours) and PDE2A (1.7-fold, 8 hours and 1.2-fold after 24 hours).
Positive_regulation (regulation) of PDE2A
4) Confidence 0.38 Published 2010 Journal Headache Section Body Doc Link 19751368 Disease Relevance 0 Pain Relevance 0
In colon cancer cells, the antineoplastic effects of exisulind have been attributed, in part, to induction of cyclic guanosine 3',5'-monophosphate (cGMP) signaling through inhibition of cGMP-specific phosphodiesterases, which elevates intracellular cGMP, and novel expression of cGMP-dependent protein kinase (PKG) Ibeta, the presumed downstream effector mediating apoptosis.
Positive_regulation (induction) of cGMP in colon associated with colon cancer and apoptosis
5) Confidence 0.12 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731751 Disease Relevance 0.75 Pain Relevance 0.12
Accumulation of intracellular cGMP produced by an exogenous cell-permeant analogue of cGMP or a potent agonist of guanylyl cyclase C yielded cytostasis without cell death.
Positive_regulation (Accumulation) of cGMP associated with agonist and death
6) Confidence 0.12 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731751 Disease Relevance 0.77 Pain Relevance 0.12
Surprisingly, the antiproliferative effects of induced cGMP accumulation were paradoxically less than additive, rather than synergistic, when combined with exisulind.
Positive_regulation (accumulation) of cGMP
7) Confidence 0.12 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731751 Disease Relevance 0.78 Pain Relevance 0.11
Further, although exisulind induced expression of PKG Ibeta, it did not elevate intracellular cGMP and its efficacy was not altered by inhibition or activation of PKG I.
Neg (not) Positive_regulation (elevate) of cGMP
8) Confidence 0.12 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731751 Disease Relevance 0.73 Pain Relevance 0.10
The secondary increase of cGMP activates protein kinase G (PKG) and induces transcription of caspase genes, resulting in apoptosis. cGMP-PDEs comprise 11 gene families.
Positive_regulation (increase) of cGMP associated with apoptosis
9) Confidence 0.06 Published 2001 Journal Curr Opin Investig Drugs Section Abstract Doc Link 11569947 Disease Relevance 0.57 Pain Relevance 0.08
It is in this context noteworthy that several in vitro studies have shown that activation of postsynaptic 5-HT2A/2C receptors decrease cGMP levels generated in response to NMDA administration (Marcoli et al 1997; Maura et al 2000).
Positive_regulation (generated) of cGMP
10) Confidence 0.01 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.72 Pain Relevance 0.35
Soluble guanylate cyclase represents the most important NO receptor in the brain (Dawson VL and Dawson TM 1995), with its activation by NO following glutamate-mediated activation of the NMDA receptor leading to an increase in the second messenger – cyclic guanosine monophosphate (cGMP) (Fedele et al 2001).
Positive_regulation (activation) of cGMP in brain associated with glutamate and nmda receptor
11) Confidence 0.01 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0 Pain Relevance 0.23
Soluble guanylate cyclase represents the most important NO receptor in the brain (Dawson VL and Dawson TM 1995), with its activation by NO following glutamate-mediated activation of the NMDA receptor leading to an increase in the second messenger – cyclic guanosine monophosphate (cGMP) (Fedele et al 2001).
Positive_regulation (increase) of cGMP in brain associated with glutamate and nmda receptor
12) Confidence 0.01 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0 Pain Relevance 0.23

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