INT75831

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Context Info
Confidence 0.63
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 24
Disease Relevance 13.56
Pain Relevance 4.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
intracellular (IL8)
Anatomy Link Frequency
liver 4
cartilage 2
coronary artery 2
joints 2
blood 2
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 198 100.00 Very High Very High Very High
Osteoarthritis 63 99.84 Very High Very High Very High
cytokine 216 99.80 Very High Very High Very High
Inflammation 270 99.40 Very High Very High Very High
Versed 7 99.00 Very High Very High Very High
ischemia 15 98.74 Very High Very High Very High
Inflammatory mediators 3 98.48 Very High Very High Very High
Cannabinoid receptor 7 97.28 Very High Very High Very High
imagery 5 96.72 Very High Very High Very High
fibrosis 18 94.60 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 163 99.98 Very High Very High Very High
Osteoarthritis 66 99.84 Very High Very High Very High
Neutrophil Disorders 1 99.80 Very High Very High Very High
Chronic Hepatitis 27 99.56 Very High Very High Very High
Hepatitis C Virus Infection 18 99.48 Very High Very High Very High
INFLAMMATION 301 99.40 Very High Very High Very High
Hypoxia 30 98.92 Very High Very High Very High
Disease 106 98.80 Very High Very High Very High
Cv Unclassified Under Development 13 98.74 Very High Very High Very High
Bordatella Infection 3 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is interesting to note that in this example, group A seems to be the more appropriate control, because an increase in IL8 mRNA levels from mild (A1F1) to advanced disease (A2F3) is observed, suggesting a model with IL8 activation during fibrogenesis.


Positive_regulation (increase) of Transcription (levels) of IL8 associated with fibrosis and disease
1) Confidence 0.63 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.98 Pain Relevance 0.04
CXCL8 mRNA expression in all seven CI joints (IOD 17,109 ± 6944) was specifically increased compared with the eight CU joints (IOD 2774 ± 1415) (P < 0.05) and the five control subjects (IOD 180 ± 66) (Figs 3 and 4).
Positive_regulation (increased) of Transcription (expression) of CXCL8 in joints
2) Confidence 0.51 Published 2001 Journal Arthritis Res Section Body Doc Link PMC17826 Disease Relevance 0.10 Pain Relevance 0.10
Northern blot analysis also revealed increased IL-8 mRNA levels in the presence of both midazolam and propofol, which was confirmed by molecular imaging.
Positive_regulation (increased) of Transcription (levels) of IL-8 associated with versed and imagery
3) Confidence 0.47 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9620522 Disease Relevance 0.14 Pain Relevance 0.32
Similar to IL-8 protein levels released into the basolateral supernatants, IL-8 mRNA levels were enhanced by both ISO and BD photochemical products, although the levels did not reach statistical significance.


Positive_regulation (enhanced) of Transcription (levels) of IL-8
4) Confidence 0.47 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
The enhancement of IL-8 and MCP-1 gene transcription and protein production was shown to be pertussis toxin sensitive attesting that this phenomenon was a Gi protein-coupled receptor-mediated process as expected for cannabinoid receptors.
Positive_regulation (enhancement) of Transcription (transcription) of IL-8 associated with bordatella infection and cannabinoid receptor
5) Confidence 0.45 Published 1999 Journal FEBS Lett. Section Abstract Doc Link 10218491 Disease Relevance 0.10 Pain Relevance 0.67
Moreover, H. pylori induced the activation of NF-kappaB as well as AP-1, leading to IL-8 gene transcription.
Positive_regulation (leading) of Transcription (transcription) of IL-8
6) Confidence 0.44 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753246 Disease Relevance 0.78 Pain Relevance 0.09
IL8 mRNA expression increases from mild chronic hepatitis C (A1F1) to severe liver lesions (A2F3).
Positive_regulation (increases) of Transcription (expression) of IL8 in liver associated with chronic hepatitis and disease
7) Confidence 0.42 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 1.62 Pain Relevance 0.12
IL8 was investigated because it has been shown in culture cells that the HCV nonstructural 5A protein induces IL8.17 IL8 mRNA expression increases from mild chronic hepatitis C (A1F1) to severe liver lesions (A2F3) (Fig. 4).
Positive_regulation (induces) of Transcription (expression) of IL8 in liver associated with chronic hepatitis and hepatitis c virus infection
8) Confidence 0.42 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.97 Pain Relevance 0.05
In addition, rebamipide suppressed H. pylori-induced IL-8 gene expression at the transcriptional level as revealed by northern blotting analysis and luciferase activity in cells that were transfected with a luciferase expression vector linked with a 5'-flanking region of the IL-8 gene (bp -133 to +44).
Positive_regulation (induced) of Transcription (expression) of IL-8
9) Confidence 0.41 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753246 Disease Relevance 0.79 Pain Relevance 0.14
In this study, we show that human cere-bromicrovascular endothelial cells (HCEC) subjected to a 4 h in vitro ischemia (hypoxia + glucose deprivation) followed by a 4-24 h recovery express elevated levels of ICAM-1, IL-8, and MCP-1 mRNAs (semi-quantitative RT-PCR) and secrete increased amounts of the immunoreactive chemokines IL-8 and MCP-1 (ELISA).
Positive_regulation (levels) of Transcription (express) of IL-8 in HCEC associated with chemokine, hypoxia and ischemia
10) Confidence 0.40 Published 2000 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 11450070 Disease Relevance 0.97 Pain Relevance 0.43
OA cartilage produces IL-6 and IL-8, and quantitative RT-PCR studies have shown elevated IL-6 and IL-8 mRNA levels in OA cartilage as compared to normal cartilage [10, 50].
Positive_regulation (elevated) of Transcription (levels) of IL-8 in cartilage associated with osteoarthritis
11) Confidence 0.31 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 1.29 Pain Relevance 0.98
This result shows that live V. parahaemolyticus actively induces IL-8 transcription.
Positive_regulation (induces) of Transcription (transcription) of IL-8
12) Confidence 0.19 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC3022711 Disease Relevance 0.48 Pain Relevance 0.11
Microarray analysis of blood PMN from patients with X-linked chronic granulomatous disease revealed increased mRNA levels for only two chemokines, namely CXCL8 and CXCL1 [51].
Positive_regulation (increased) of Transcription (levels) of CXCL8 in blood associated with chemokine and neutrophil disorders
13) Confidence 0.15 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212580 Disease Relevance 0.60 Pain Relevance 0.59
vp1680 strains induced similar levels of IL-8 transcription in the Caco-2 cells to the WT V. parahaemolyticus, while the ?
Positive_regulation (levels) of Transcription (transcription) of IL-8 in Caco-2 associated with sprains and strains
14) Confidence 0.14 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC3022711 Disease Relevance 0.43 Pain Relevance 0.05
These results demonstrate that V. parahaemolyticus actively induces the transcription and production of IL-8 by the host cell.
Positive_regulation (induces) of Transcription (transcription) of IL-8
15) Confidence 0.14 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC3022711 Disease Relevance 0.24 Pain Relevance 0
vscN2 strain induced a high level of IL-8 transcription (more than 4-fold the level of IL-8 transcript induced by the WT V. parahaemolyticus).
Positive_regulation (induced) of Transcription (transcription) of IL-8 associated with sprains and strains
16) Confidence 0.14 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC3022711 Disease Relevance 0.36 Pain Relevance 0.03
We evaluated mRNA expression and protein production of CCL2, CXCL8, CXCL9, CXCL10, IFN-gamma and IL-10 in vitro as well as the expression of the CCR2 and CXCR3 receptors in peripheral blood mononuclear cells (PBMCs) of patients with coronary artery disease (CAD) and healthy controls in the presence or absence of oxidized LDL (oxLDL).
Positive_regulation (evaluated) of Transcription (expression) of CXCL8 in coronary artery associated with coronary artery disease
17) Confidence 0.11 Published 2009 Journal Int. J. Cardiol. Section Abstract Doc Link 18617279 Disease Relevance 0.69 Pain Relevance 0.26
The development of compensatory immune mechanisms for the lack of CCR2 was evidenced by the increased mRNA expression for other CCL and CCR molecules (most notably IL8 and its receptor involved in neutrophil recruitment).
Positive_regulation (increased) of Transcription (expression) of IL8 in neutrophil
18) Confidence 0.09 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.88 Pain Relevance 0.08
In addition to inducing transcription of a number of ARE-genes, such as interleukin-8 (IL-8), IFN-?
Positive_regulation (inducing) of Transcription (transcription) of interleukin-8
19) Confidence 0.09 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.88 Pain Relevance 0.68
activated IL-8 mRNA production but epinephrine had no effect on IL-8 transcripts.
Positive_regulation (activated) of Transcription (production) of IL-8
20) Confidence 0.07 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0 Pain Relevance 0.12

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