INT75832

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 20.77
Pain Relevance 6.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
intracellular (IL8)
Anatomy Link Frequency
liver 4
epithelial cell 4
plasma 2
middle ear 2
macrophage 2
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 480 100.00 Very High Very High Very High
cytokine 432 100.00 Very High Very High Very High
chemokine 111 100.00 Very High Very High Very High
Inflammatory mediators 40 100.00 Very High Very High Very High
substance P 7 99.26 Very High Very High Very High
Crohn's disease 53 98.38 Very High Very High Very High
Versed 7 97.76 Very High Very High Very High
Prostatitis 1 95.52 Very High Very High Very High
pain pelvic 1 94.72 High High
fibrosis 19 94.60 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 582 100.00 Very High Very High Very High
Respiratory Syncytial Virus 200 100.00 Very High Very High Very High
Infection 184 100.00 Very High Very High Very High
Cancer 162 100.00 Very High Very High Very High
Hemorrhagic Shock 23 100.00 Very High Very High Very High
Necrosis 15 100.00 Very High Very High Very High
Otitis Media 134 99.84 Very High Very High Very High
Nociception 10 99.80 Very High Very High Very High
Hypoxia 28 99.78 Very High Very High Very High
Chlamydia Infection 4 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lipopolysaccharide increased extracellular accumulation of interleukin-8, which was suppressed by both propofol (P = 0.025) and midazolam (P = 0.028).
Positive_regulation (increased) of Positive_regulation (accumulation) of interleukin-8 associated with versed
1) Confidence 0.70 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9620522 Disease Relevance 0.13 Pain Relevance 0.26
NF-kappaB inhibitors blocked the ability of Ca(2+) to induce IL-8 production, and the activation of NF-kappaB was required for intracellular Ca(2+)-induced up-regulation of IL-8.
Positive_regulation (-induced) of Positive_regulation (up-regulation) of IL-8
2) Confidence 0.48 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.14 Pain Relevance 0.18
NF-kappaB inhibitors blocked the ability of Ca(2+) to induce IL-8 production, and the activation of NF-kappaB was required for intracellular Ca(2+)-induced up-regulation of IL-8.
Positive_regulation (required) of Positive_regulation (up-regulation) of IL-8
3) Confidence 0.48 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.14 Pain Relevance 0.18
IL8 was investigated because it has been shown in culture cells that the HCV nonstructural 5A protein induces IL8.17 IL8 mRNA expression increases from mild chronic hepatitis C (A1F1) to severe liver lesions (A2F3) (Fig. 4).
Positive_regulation (induces) of Positive_regulation (increases) of IL8 in liver associated with chronic hepatitis and hepatitis c virus infection
4) Confidence 0.45 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.98 Pain Relevance 0.05
IL8 was investigated because it has been shown in culture cells that the HCV nonstructural 5A protein induces IL8.17 IL8 mRNA expression increases from mild chronic hepatitis C (A1F1) to severe liver lesions (A2F3) (Fig. 4).
Positive_regulation (induces) of Positive_regulation (increases) of IL8 in liver associated with chronic hepatitis and hepatitis c virus infection
5) Confidence 0.45 Published 2008 Journal Hepatology (Baltimore, Md.) Section Body Doc Link PMC2816363 Disease Relevance 0.98 Pain Relevance 0.05
Pyocyanin-induced synergism with interleukin (IL)-1 or tumour necrosis factor (TNF) in triggering IL-8 release has been documented previously.
Positive_regulation (Pyocyanin-induced) of Positive_regulation (triggering) of IL-8 associated with necrosis and cancer
6) Confidence 0.41 Published 2006 Journal Respir Med Section Abstract Doc Link 16448811 Disease Relevance 0.20 Pain Relevance 0.05
Interestingly, the patients with PDR/CRVO showed increase of VEGF, but not DME/BRVO which had a significant increase of IL-6, IL-8, and MCP-1 (Figure 1).
Positive_regulation (increase) of Positive_regulation (increase) of IL-8
7) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780733 Disease Relevance 1.20 Pain Relevance 0.03
This IL-8 induction was dependent on the AR as the inhibition of AR expression by siRNA prevented IL-8 secretion following androgen stimulation (Figure 5C).
Positive_regulation (dependent) of Positive_regulation (induction) of IL-8
8) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920336 Disease Relevance 0.37 Pain Relevance 0.15
Moreover, induction of IL17A and IL21 was significantly more pronounced in UC than in colonic CD, and this induction was associated with more intense inflammation as defined by increased induction of IL8.
Positive_regulation (increased) of Positive_regulation (induction) of IL8 associated with inflammatory bowel disease, inflammation and crohn's disease
9) Confidence 0.29 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 1.31 Pain Relevance 0.57
In neutrophilic asthma, there is evidence of neutrophil activation with increased neutrophil elastase and IL-8 in induced sputum [54].
Positive_regulation (increased) of Positive_regulation (increased) of IL-8 in neutrophil associated with asthma
10) Confidence 0.29 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2873624 Disease Relevance 1.46 Pain Relevance 0.25
At a range of concentrations, exposure of BEAS-2B cells to Substance P (SP) or calcitonin gene related protein resulted in immediate increases in intracellular calcium ([Ca(2+)](i)), the synthesis of the transcripts for the inflammatory cytokines, IL-6, IL-8 and TNFalpha after 2 h exposure, and the release of their proteins after 6 h exposure.
Positive_regulation (resulted) of Positive_regulation (increases) of IL-8 in BEAS-2B associated with inflammation, cytokine and substance p
11) Confidence 0.28 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657523 Disease Relevance 0.33 Pain Relevance 0.80
However, ICD could not significantly stimulate IL8 induction in a cultured macrophage cell line (THP1) and therefore, may not be a notable proinflammatory agent.



Neg (not) Positive_regulation (stimulate) of Neg (not) Positive_regulation (induction) of IL8 in macrophage
12) Confidence 0.26 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2195454 Disease Relevance 0.76 Pain Relevance 0.04
B activity observed following RSV-infection might lead to transcriptional induction of cytokines such as IL-8, MIP-1?
Positive_regulation (following) of Positive_regulation (induction) of IL-8 associated with infection, respiratory syncytial virus and cytokine
13) Confidence 0.23 Published 2004 Journal BMC Microbiol Section Body Doc Link PMC481065 Disease Relevance 1.37 Pain Relevance 0.56
B activity observed following RSV-infection might lead to transcriptional induction of cytokines such as IL-8, MIP-1?
Spec (might) Positive_regulation (lead) of Positive_regulation (induction) of IL-8 associated with infection, respiratory syncytial virus and cytokine
14) Confidence 0.23 Published 2004 Journal BMC Microbiol Section Body Doc Link PMC481065 Disease Relevance 1.35 Pain Relevance 0.55
Next, levels of IL-8, PGE2, and LTB4 at basal state and following LPS stimulation were assessed using BES from well-characterized 16 COPD and 13 non-COPD smokers (Table 1).
Positive_regulation (following) of Positive_regulation (stimulation) of IL-8 associated with nicotine addiction and pulmonary disease
15) Confidence 0.21 Published 2007 Journal Respir Res Section Body Doc Link PMC2214730 Disease Relevance 0.51 Pain Relevance 0.08
Lipopolysaccharide-stimulated IL-8 concentrations were at most two-fold higher than control concentrations, and were increased on the choriodecidual side of the membranes only.
Positive_regulation (increased) of Positive_regulation (stimulated) of IL-8
16) Confidence 0.19 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2774314 Disease Relevance 0.19 Pain Relevance 0.16
PGN and CpG DNA induced a significant increase of both IL-6 and IL-8 in conjunctival epithelial cells.
Positive_regulation (induced) of Positive_regulation (increase) of IL-8 in epithelial cells
17) Confidence 0.15 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.11 Pain Relevance 0
PGN-stimulated increase of IL-6 and IL-8 was observed in three out of four different primary cultured limbal epithelial cell samples.
Positive_regulation (stimulated) of Positive_regulation (increase) of IL-8 in epithelial cell
18) Confidence 0.15 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.12 Pain Relevance 0
This suggestion is supported by the following observations: (a) pretreatment of the peritoneal cavities with antisera against these cytokines reduced the nociceptive responses induced by these stimuli; (b) peritoneal cells harvested from cavities injected with zymosan or acetic acid released both interleukin 1beta and TNF-alpha; (c) although individual injection of TNF-alpha, interleukin 1beta or interleukin 8 did not induce the nociceptive effect, intraperitoneal injection of a mixture of these three recombinant cytokines caused a significant nociceptive writhing response.
Neg (not) Positive_regulation (induce) of Positive_regulation (injection) of interleukin 8 in cavities associated with nociception and cytokine
19) Confidence 0.14 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10633169 Disease Relevance 0.89 Pain Relevance 0.10
In order to obtain a better overview of the signalling pathways leading to IL-8 activation in response to V. parahaemolyticus, the pharmacologic inhibitors of the MAPK signalling pathways were added during co-incubation and IL-8 secretion was quantified by ELISA (Figure 6).
Positive_regulation (leading) of Positive_regulation (activation) of IL-8
20) Confidence 0.13 Published 2010 Journal BMC Microbiol Section Body Doc Link PMC3022711 Disease Relevance 0.18 Pain Relevance 0

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