INT75833

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Context Info
Confidence 0.53
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 6.69
Pain Relevance 5.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL8) extracellular space (IL8) extracellular region (IL8)
intracellular (IL8)
Anatomy Link Frequency
HCEC 2
melanocyte 2
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 27 100.00 Very High Very High Very High
ischemia 8 100.00 Very High Very High Very High
chemokine 37 99.84 Very High Very High Very High
corticosteroid 8 99.74 Very High Very High Very High
lidocaine 7 99.74 Very High Very High Very High
Inflammation 128 99.60 Very High Very High Very High
Versed 8 98.64 Very High Very High Very High
Inflammatory mediators 16 95.20 Very High Very High Very High
Clonidine 2 94.72 High High
cINOD 10 91.36 High High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 7 100.00 Very High Very High Very High
INFLAMMATION 161 99.60 Very High Very High Very High
Acne 8 97.76 Very High Very High Very High
Gastroesophageal Reflux Disease 12 96.16 Very High Very High Very High
Esophageal Disease 22 95.68 Very High Very High Very High
Pulmonary Disease 108 94.80 High High
Inflammatory Bowel Disease 7 87.28 High High
Disease 12 85.96 High High
Airway Remodeling 2 85.56 High High
Necrosis 4 84.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitory effect of NHE inhibition on IL-8 was associated with a decrease in IL-8 mRNA accumulation.
Negative_regulation (decrease) of Positive_regulation (accumulation) of IL-8
1) Confidence 0.53 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12065299 Disease Relevance 0.89 Pain Relevance 0.33
The immunosuppressant cyclosporin A (50 microM) partially reduced the ischemia-stimulated IL-8 and MCP-1 secretion by HCEC.
Negative_regulation (reduced) of Positive_regulation (stimulated) of IL-8 in HCEC associated with ischemia
2) Confidence 0.50 Published 2000 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 11450070 Disease Relevance 1.14 Pain Relevance 0.60
Lipopolysaccharide increased extracellular accumulation of interleukin-8, which was suppressed by both propofol (P = 0.025) and midazolam (P = 0.028).
Negative_regulation (suppressed) of Positive_regulation (accumulation) of interleukin-8 associated with versed
3) Confidence 0.43 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9620522 Disease Relevance 0.13 Pain Relevance 0.26
A novel class of 2-(R)-phenylpropionamides has been recently reported to inhibit in vitro and in vivo interleukin-8 (CXCL8)-induced biological activities.
Negative_regulation (inhibit) of Positive_regulation (induced) of interleukin-8
4) Confidence 0.43 Published 2005 Journal J. Med. Chem. Section Abstract Doc Link 15801837 Disease Relevance 0.09 Pain Relevance 0.09
The suppressive effect of amiloride on endotoxin-induced IL-8 production was associated with a decreased accumulation of IL-8 mRNA.
Negative_regulation (decreased) of Positive_regulation (accumulation) of IL-8
5) Confidence 0.38 Published 2002 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 12107048 Disease Relevance 0.46 Pain Relevance 0.35
Lidocaine (0.5 mg/mL) decreased IL-1beta (1.89 +/- 0.11 versus 4.16 +/- 1.27 pg/mL; P = 0.009), IL-6 (65.5 +/- 5.14 versus 162 +/- 11.5 pg/mL; P < 0.001), and IL-8 (3869 +/- 785 versus 14,961 +/- 406 pg/mL; P < 0.001) concentrations compared with the control.
Negative_regulation (decreased) of Positive_regulation (concentrations) of IL-8 associated with lidocaine
6) Confidence 0.32 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15673867 Disease Relevance 0.39 Pain Relevance 0.65
The induced IL-8 and MCP-1 proteins were almost completely supporessed by U0126, a specific mitogen-activated protein kinase kinase (MEK) inhibitor, or by SB203580, a selective p38 inhibitor.
Negative_regulation (inhibitor) of Positive_regulation (induced) of IL-8
7) Confidence 0.27 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.15 Pain Relevance 0.33
Induction of IL-8 and MCP-1 was abrogated by Ro318220, an inhibitor of PKC, as well as by genistein or herbimycin A, inhibitors of PTK.
Negative_regulation (abrogated) of Positive_regulation (Induction) of IL-8
8) Confidence 0.27 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.16 Pain Relevance 0.37
The induced IL-8 and MCP-1 proteins were almost completely supporessed by U0126, a specific mitogen-activated protein kinase kinase (MEK) inhibitor, or by SB203580, a selective p38 inhibitor.
Negative_regulation (supporessed) of Positive_regulation (induced) of IL-8
9) Confidence 0.27 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.15 Pain Relevance 0.29
The induced IL-8 and MCP-1 proteins were almost completely supporessed by U0126, a specific mitogen-activated protein kinase kinase (MEK) inhibitor, or by SB203580, a selective p38 inhibitor.
Negative_regulation (inhibitor) of Positive_regulation (induced) of IL-8
10) Confidence 0.27 Published 2003 Journal Exp. Eye Res. Section Abstract Doc Link 12697421 Disease Relevance 0.16 Pain Relevance 0.34
Two-hour pre-treatment with 10 mM of both molecules significantly reverted the stimulation of IL-6, IL-8, ICAM-1 and Mcp-1, whereas the effect on I?
Negative_regulation (reverted) of Positive_regulation (stimulation) of IL-8
11) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875647 Disease Relevance 0 Pain Relevance 0
Treatment with interleukin-1beta resulted in a marked increase in interleukin-8 release that was partially blocked by coincubation with alpha-melanocyte-stimulating hormone in a dose-dependent manner.
Negative_regulation (blocked) of Positive_regulation (increase) of interleukin-8 in melanocyte
12) Confidence 0.24 Published 2002 Journal J. Invest. Dermatol. Section Abstract Doc Link 11874495 Disease Relevance 0.73 Pain Relevance 0.53
Since cellular immune infiltrate is a prerequisite for severe inflammation and tissue damage, inhibition of IL-8, SP and PAF-induced PBL migration and activation may provide potential targets for therapy.


Negative_regulation (inhibition) of Positive_regulation (activation) of IL-8 associated with inflammation and substance p
13) Confidence 0.19 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.59 Pain Relevance 0.65
One surprising and unexpected finding of this study was the decrease in IL-8 induced by S. flexneri in our model.
Negative_regulation (decrease) of Positive_regulation (induced) of IL-8
14) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2653194 Disease Relevance 0.47 Pain Relevance 0.17
Corticosteroids also do not inhibit the increased concentrations of IL-8 and TNF-?
Negative_regulation (inhibit) of Positive_regulation (increased) of IL-8 associated with corticosteroid
15) Confidence 0.03 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 1.20 Pain Relevance 0.64

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