INT7584

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Context Info
Confidence 0.78
First Reported 1986
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 112
Total Number 112
Disease Relevance 39.15
Pain Relevance 25.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
hypothalamus 9
amygdala 6
neurons 4
striatum 3
brain 3
Crh (Mus musculus)
Pain Link Frequency Relevance Heat
Dynorphin 170 100.00 Very High Very High Very High
Enkephalin 17 100.00 Very High Very High Very High
Somatostatin 10 100.00 Very High Very High Very High
Cholecystokinin 2 100.00 Very High Very High Very High
Calcitonin gene-related peptide 2 100.00 Very High Very High Very High
antinociception 11 99.96 Very High Very High Very High
amygdala 592 99.84 Very High Very High Very High
Eae 71 99.84 Very High Very High Very High
antagonist 147 99.82 Very High Very High Very High
cytokine 628 99.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 833 100.00 Very High Very High Very High
Anxiety Disorder 633 99.92 Very High Very High Very High
Stress 1921 99.82 Very High Very High Very High
Hypoglycemia 95 99.82 Very High Very High Very High
Urological Neuroanatomy 4 99.66 Very High Very High Very High
Hypersensitivity 36 99.62 Very High Very High Very High
Depression 263 99.52 Very High Very High Very High
Nociception 7 99.34 Very High Very High Very High
Functional Bowel Disorder 4 98.72 Very High Very High Very High
Aggression 394 98.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It also decreases CRF expression in the brain.
Gene_expression (expression) of CRF in brain
1) Confidence 0.78 Published 2010 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 20447436 Disease Relevance 0.67 Pain Relevance 0.28
These results suggest that visceral nociception may upregulate both galanin and CRH gene expression in the hypothalamic and limbic nuclei.
Gene_expression (expression) of CRH gene in visceral associated with nociception
2) Confidence 0.78 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17335920 Disease Relevance 0.46 Pain Relevance 0.58
CRF is produced and released from a variety of cell types, making it difficult to distinguish the specific role of CRF from other neurotransmitters with which it colocalizes.
Gene_expression (produced) of CRF associated with neurotransmitter
3) Confidence 0.77 Published 2010 Journal Biol. Psychiatry Section Abstract Doc Link 20303068 Disease Relevance 0.51 Pain Relevance 0.15
A novel transgenic mouse for gene-targeting within cells that express corticotropin-releasing factor.
Gene_expression (express) of corticotropin-releasing factor associated with targeted disruption
4) Confidence 0.77 Published 2010 Journal Biol. Psychiatry Section Title Doc Link 20303068 Disease Relevance 0.59 Pain Relevance 0.13
Crossing CRFp3.0Cre with a fluorescent reporter strain results in Cre-dependent green fluorescent protein expression within CRF-producing cells.
Gene_expression (producing) of CRF associated with sprains and strains
5) Confidence 0.77 Published 2010 Journal Biol. Psychiatry Section Abstract Doc Link 20303068 Disease Relevance 0.58 Pain Relevance 0.12
Intrathecally (i.t.) administered corticotropin-releasing factor (CRF) has been shown to produce antinociception in the mouse abdominal stretching (writhing) assay.
Gene_expression (produce) of CRF associated with antinociception
6) Confidence 0.75 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1848633 Disease Relevance 0.08 Pain Relevance 0.63
Avp, oxytocin (Oxt) and Crh mRNA expression in the PVN did not change in fluoxetine-treated male Avpr1b KO or wild-type mice.
Gene_expression (expression) of Crh mRNA in PVN associated with targeted disruption and fluoxetine
7) Confidence 0.71 Published 2008 Journal Psychoneuroendocrinology Section Abstract Doc Link 18243568 Disease Relevance 0.59 Pain Relevance 0.95
Mice with food allergy display higher levels of anxiety and increased serum corticosterone levels, and allergy-activated neurons express corticotropin-releasing factor (CRF) in the PVN and CeA.
Gene_expression (express) of corticotropin-releasing factor in CeA associated with food hypersensitivity, hypersensitivity, anxiety disorder and amygdala
8) Confidence 0.71 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17192560 Disease Relevance 0.70 Pain Relevance 0.30
Mice with food allergy display higher levels of anxiety and increased serum corticosterone levels, and allergy-activated neurons express corticotropin-releasing factor (CRF) in the PVN and CeA.
Gene_expression (express) of CRF in CeA associated with food hypersensitivity, hypersensitivity, anxiety disorder and amygdala
9) Confidence 0.71 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17192560 Disease Relevance 0.70 Pain Relevance 0.30
Based on the published data cited above, we would have expected to see increased Npy and decreased Crh expression in the hypothalami of deprived pups.
Gene_expression (expression) of Crh
10) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.23 Pain Relevance 0.03
In postnatal day 8 or 9 mice, prolonged (>4 hr) maternal separation leads to increased stress as indicated by elevated corticosterone and ACTH in the circulation, as well as reduced corticotropin releasing hormone (CRH) expression in the arcuate nucleus of the hypothalamus [10], [17].
Gene_expression (expression) of CRH in hypothalamus associated with stress
11) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827556 Disease Relevance 0.35 Pain Relevance 0.03
We found that the expression of Crh in hypothalamus was similar in Mecp2?
Gene_expression (expression) of Crh in hypothalamus
12) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.41 Pain Relevance 0
Restraint stress, subcutaneous morphine (1.75 mg/kg), and ICV corticotropin-releasing factor (CRF; 75 ng) each produced a decreased mean time per contact with novel stimuli.
Gene_expression (produced) of corticotropin-releasing factor associated with stress and morphine
13) Confidence 0.67 Published 1986 Journal Regul. Pept. Section Abstract Doc Link 3492730 Disease Relevance 0.31 Pain Relevance 0.32
Restraint stress, subcutaneous morphine (1.75 mg/kg), and ICV corticotropin-releasing factor (CRF; 75 ng) each produced a decreased mean time per contact with novel stimuli.
Gene_expression (produced) of CRF associated with stress and morphine
14) Confidence 0.67 Published 1986 Journal Regul. Pept. Section Abstract Doc Link 3492730 Disease Relevance 0.31 Pain Relevance 0.32
CRH was rapidly transported out of the brain with a half-time disappearance (t1/2) of 15 min, much faster than albumin (t1/2 = 50 min).
Gene_expression (transported) of CRH in brain
15) Confidence 0.67 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9124340 Disease Relevance 0.13 Pain Relevance 0.07
Microarray results indicated the inhibitory effects of corticotropin-releasing factor (CRF) receptor 1 (CRFR1) and GR antagonists (antalarmin and RU486, respectively, blocked 65% of ethanol activation, P < 0.05) on gene expression activation of the B3 subcluster (Figure 4f, g).
Gene_expression (effects) of corticotropin-releasing factor associated with antagonist
16) Confidence 0.65 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0 Pain Relevance 0.17
Central administration of corticotropin-releasing hormone increases anxiety-like behaviour and arousal in rodents, and increased anxiety-like behaviour has been shown in mice overproducing corticotropin-releasing hormone on an elevated plus maze and in a dark-light emergence task.
Gene_expression (overproducing) of corticotropin-releasing hormone associated with anxiety disorder
17) Confidence 0.65 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12099906 Disease Relevance 0.71 Pain Relevance 0.08
Conditioned fear was decreased 1 h but not 24 h after conditioning in transgenic mice, and immobility was decreased [corrected] in forced swimming in corticotropin-releasing hormone overexpressors.
Gene_expression (overexpressors) of corticotropin-releasing hormone associated with targeted disruption and anxiety disorder
18) Confidence 0.65 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12099906 Disease Relevance 1.12 Pain Relevance 0.23
Moreover, sensorimotor performance on a rotorod was impaired, and water intake was reduced in corticotropin-releasing hormone overproducing mice, while no changes were seen in nociception.
Gene_expression (overproducing) of corticotropin-releasing hormone associated with nociception
19) Confidence 0.65 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12099906 Disease Relevance 1.07 Pain Relevance 0.23
Effects of transgenic overproduction of CRH on anxiety-like behaviour.
Gene_expression (overproduction) of CRH associated with targeted disruption and anxiety disorder
20) Confidence 0.65 Published 2002 Journal Eur. J. Neurosci. Section Title Doc Link 12099906 Disease Relevance 0.99 Pain Relevance 0.10

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