INT75841

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Context Info
Confidence 0.47
First Reported 1998
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 66
Total Number 68
Disease Relevance 29.14
Pain Relevance 7.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 33
SH2 1
tails 1
naive T cell 1
synovial joints 1
Trav6-3 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 941 99.80 Very High Very High Very High
Osteoarthritis 50 99.48 Very High Very High Very High
Arthritis 438 99.40 Very High Very High Very High
Inflammation 820 99.28 Very High Very High Very High
rheumatoid arthritis 636 99.28 Very High Very High Very High
agonist 89 98.40 Very High Very High Very High
chemokine 125 98.06 Very High Very High Very High
opioid receptor 12 95.24 Very High Very High Very High
metalloproteinase 52 93.60 High High
tolerance 82 92.72 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 53 99.60 Very High Very High Very High
Apoptosis 223 99.58 Very High Very High Very High
Osteoarthritis 50 99.48 Very High Very High Very High
Arthritis 352 99.40 Very High Very High Very High
Lymphatic System Cancer 277 99.38 Very High Very High Very High
Death 117 99.32 Very High Very High Very High
INFLAMMATION 890 99.28 Very High Very High Very High
Rheumatoid Arthritis 639 99.28 Very High Very High Very High
Leukemia 45 99.20 Very High Very High Very High
Disease 640 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such features of drug recognition may open new therapeutic possibilities to intervene with TCR-MHC interactions in a selective way.
TCR Binding (interactions) of
1) Confidence 0.47 Published 1998 Journal Int. Immunol. Section Abstract Doc Link 9620607 Disease Relevance 0 Pain Relevance 0.41
It has been proposed that TCR engagement by endogenous Sags would be one epigenetic factor that contributes to the evolution and selection of murine neoplastic T cell clones [31].
TCR Binding (engagement) of in T cell
2) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.06 Pain Relevance 0
Significantly decreased production of the proinflammatory cytokines IFN-gamma and IL-17 is observed in prostate-draining lymph node T cells from Elocalcitol-treated NOD mice stimulated by TCR ligation.
TCR Binding (ligation) of in T cells associated with diabetes mellitus and cytokine
3) Confidence 0.17 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17142748 Disease Relevance 1.06 Pain Relevance 0.33
Without antigen, however, phase two is abbreviated and T cell–DC contacts do not result in the expression of activation markers (CD25), cytokine production (IL-2) or cell division but do induce TCR signaling, which might represent TCR interaction with self-MHC ligands required for optimal foreign antigen reactivity [42].
TCR Spec (might) Binding (interaction) of in T cell associated with cytokine
4) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297591 Disease Relevance 0 Pain Relevance 0.09
Taking into account that it has been proposed that TCR engagement by endogenous Sags would be one epigenetic factor that contributes to the selection of murine pre-neoplastic T cell clones [31] we first investigated whether lymphomas bearing V?
TCR Binding (engagement) of in T cell associated with lymphatic system cancer
5) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.89 Pain Relevance 0.08
Since CD69 is upregulated in proliferating T–cells in a TCR–dependent manner [20], these results suggest that the proliferation of those leukemia/lymphoma cells occurs independently of TCR engagement.
TCR Binding (engagement) of in T-cells associated with leukemia and lymphatic system cancer
6) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2788417 Disease Relevance 1.13 Pain Relevance 0
is rate-limiting, thereby regulating the amount of TCR/CD3 complex expressed at the cell surface.8,9 In NK cells, the TCR?
TCR Binding (complex) of in NK cells
7) Confidence 0.13 Published 2007 Journal Blood Section Body Doc Link PMC1939810 Disease Relevance 0 Pain Relevance 0
After completion of TCR?
TCR Binding (completion) of
8) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.06 Pain Relevance 0
gene products are tested for useful and safe TCR interactions with self-MHC:peptide complexes.
TCR Binding (interactions) of
9) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.06 Pain Relevance 0.03
Useful TCR interactions will result in positive selection of the cell, upregulation of TCR and CD69 surface expression, and lineage commitment of CD4 SP and CD8 SP thymocytes.
TCR Binding (interactions) of in thymocytes
10) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.08 Pain Relevance 0
Recently, quiescent T cells were found to express low levels of DOR transcripts, which increased due to the following: cell culture of unstimulated murine splenocytes (depending on cell density); cross-linking the T-cell receptor (TCR) with anti-CD3-epsilon; and a single in vivo exposure to staphylococcal enterotoxin B (SEB).
TCR Binding (cross-linking) of in T cells
11) Confidence 0.11 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 11268405 Disease Relevance 0 Pain Relevance 0.32
CD28 therefore functions mainly as an amplifying mechanism to overcome signaling thresholds that, in principle, are obtainable by ligation of the TCR alone.
TCR Binding (ligation) of
12) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0 Pain Relevance 0
Both the KRN TCR and one copy of the NOD I-A?
KRN TCR Binding (Both) of
13) Confidence 0.11 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.50 Pain Relevance 0.47
As the naive T cell repertoire consists of a variety of clones that recognize the same antigen but with different avidities, we performed two experiments to address whether the lineage relationship of effector and memory subsets is dependent on the strength of the TCR–pMHC interaction.
TCR Binding (interaction) of in naive T cell
14) Confidence 0.10 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882844 Disease Relevance 0.17 Pain Relevance 0
chain paired with the already available TCR?
TCR Binding (paired) of
15) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.07 Pain Relevance 0
Retention in inflammatory lesions, however, occurs only upon recognition of antigen by the specific T-cell receptor (TCR).
TCR Binding (recognition) of in T-cell associated with inflammation
16) Confidence 0.10 Published 2006 Journal Mod Rheumatol Section Body Doc Link PMC2780633 Disease Relevance 0.77 Pain Relevance 0.39
Engagement of the TCR induces activation of signaling cascades that result in changes in the transcriptional program of the T cell.
TCR Binding (Engagement) of in T cell
17) Confidence 0.10 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.14 Pain Relevance 0.04
Alternatively, the calcium flux elicited by repeated TCR ligation might activate Bim (Bouillet et al., 2002), and, pertinently, Bim is essential for deregulated calcium flux-induced apoptosis (Bouillet et al., 1999).
TCR Binding (ligation) of associated with apoptosis
18) Confidence 0.10 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.43 Pain Relevance 0.05
Naïve T cells proliferate under acute lymphopenic conditions in response to the same factors that promote their survival in lymphoreplete mice, the cytokine IL-7 and TCR engagement with self-peptide/MHC complexes [17], [18], [19], [20], [21], [22].
TCR Binding (engagement) of in T cells associated with cytokine
19) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.49 Pain Relevance 0.11
TCR Tg CD4 T cells that recognize a class II-restricted epitope deriving from influenza hemagglutinin are adoptively transferred into recipient mice that have been infested with tick nymphs, and a bolus of soluble peptide corresponding to the cognate HA epitope is injected intradermally at the site of tick attachment.
TCR Binding (recognize) of in T cells associated with influenza virus infection
20) Confidence 0.10 Published 2009 Journal Parasit Vectors Section Body Doc Link PMC2764639 Disease Relevance 0.37 Pain Relevance 0.13

General Comments

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