INT75846

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Context Info
Confidence 0.70
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 5.73
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MC4R) signal transducer activity (MC4R)
Anatomy Link Frequency
brain 2
poly 1
MC4R (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 5 100.00 Very High Very High Very High
agonist 9 99.32 Very High Very High Very High
antagonist 16 98.80 Very High Very High Very High
Inflammation 3 93.48 High High
Opioid 2 88.96 High High
Potency 3 88.04 High High
Pain 3 81.36 Quite High
nud 3 73.84 Quite High
depression 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anorexia 45 98.52 Very High Very High Very High
Obesity 32 98.52 Very High Very High Very High
Appetite Loss 186 98.00 Very High Very High Very High
Weight Loss 57 97.68 Very High Very High Very High
Cancer 183 97.64 Very High Very High Very High
INFLAMMATION 3 93.48 High High
Targeted Disruption 3 85.52 High High
Pain 3 81.36 Quite High
Vomiting 3 81.12 Quite High
Loss Of Sense Of Smell 3 80.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of MC4R leads to higher energy expenditure, loss of appetite and weight loss [9].
Positive_regulation (Stimulation) of MC4R associated with weight loss and anorexia
1) Confidence 0.70 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2359760 Disease Relevance 2.11 Pain Relevance 0.23
Hence, both, the lower antagonist and the increased agonist potencies are compatible with an elevated MC4R function, which could explain the weight reducing effect of the variant.
Positive_regulation (elevated) of MC4R associated with antagonist and agonist
2) Confidence 0.50 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2359760 Disease Relevance 0.56 Pain Relevance 0.27
The present studies were designed to determine the specific contribution of MC4R exoloops and transmembrane domains to AGRP binding by using chimeric receptor constructs of the human melanocortin-1 receptor (hMC1R), a receptor that is not inhibited by AGRP, and the human MC4R (hMC4R), a receptor that is potently inhibited by AGRP.
Positive_regulation (using) of MC4R associated with melanocortin 1 receptor
3) Confidence 0.47 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815165 Disease Relevance 0 Pain Relevance 0.14
Here, the potential role of the melanocortin-4 receptor gene (MC4R) was investigated.
Positive_regulation (role) of melanocortin-4 receptor gene
4) Confidence 0.47 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2359760 Disease Relevance 2.23 Pain Relevance 0.23
Mutations in an A-rich upstream sequence and the AUUAAA are necessary to inactivate the MC4R P1 poly(A) site
Positive_regulation (inactivate) of MC4R in poly
5) Confidence 0.44 Published 2010 Journal EMBO J Section Body Doc Link PMC2876958 Disease Relevance 0 Pain Relevance 0
Recent studies in animal models elucidated a central role of alpha-MSH in the regulation of food intake by activation of the brain melanocortin-4-receptor (MC4-R; refs 3-5) and the linkage of human obesity to chromosome 2 in close proximity to the POMC locus, led to the proposal of an association of POMC with human obesity.
Positive_regulation (activation) of MC4-R in brain associated with obesity
6) Confidence 0.39 Published 1998 Journal Nat. Genet. Section Abstract Doc Link 9620771 Disease Relevance 0.42 Pain Relevance 0.09
Recent studies in animal models elucidated a central role of alpha-MSH in the regulation of food intake by activation of the brain melanocortin-4-receptor (MC4-R; refs 3-5) and the linkage of human obesity to chromosome 2 in close proximity to the POMC locus, led to the proposal of an association of POMC with human obesity.
Positive_regulation (activation) of melanocortin-4-receptor in brain associated with obesity
7) Confidence 0.39 Published 1998 Journal Nat. Genet. Section Abstract Doc Link 9620771 Disease Relevance 0.41 Pain Relevance 0.09

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