INT7585

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Context Info
Confidence 0.58
First Reported 1988
Last Reported 2011
Negated 3
Speculated 4
Reported most in Abstract
Documents 24
Total Number 30
Disease Relevance 9.88
Pain Relevance 12.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
blood 2
anterior pituitary 2
hippocampal formation 1
tail 1
bladder 1
Crh (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 63 100.00 Very High Very High Very High
antagonist 36 100.00 Very High Very High Very High
Morphine 25 100.00 Very High Very High Very High
Pain 18 100.00 Very High Very High Very High
Intracerebroventricular 7 100.00 Very High Very High Very High
Enkephalin 6 100.00 Very High Very High Very High
substance P 5 100.00 Very High Very High Very High
Calcium channel 2 100.00 Very High Very High Very High
Dopamine 1 100.00 Very High Very High Very High
cytokine 95 99.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cystitis 6 100.00 Very High Very High Very High
Alcohol Addiction 24 99.88 Very High Very High Very High
Cancer 25 99.74 Very High Very High Very High
Neurodegenerative Disease 5 99.62 Very High Very High Very High
Stress 266 99.52 Very High Very High Very High
Depression 78 98.64 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

6 98.40 Very High Very High Very High
Metastasis 1 98.16 Very High Very High Very High
Affective Disorder 11 98.08 Very High Very High Very High
Hypertension 8 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reciprocal modulation of corticotropin-releasing factor and interleukin-1 receptors following ether-laparotomy stress in the mouse.
Regulation (modulation) of corticotropin-releasing factor associated with stress and anesthesia
1) Confidence 0.58 Published 1994 Journal Brain Res. Section Title Doc Link 7827996 Disease Relevance 0.84 Pain Relevance 0.14
This cyclic expression of CRH is not abolished in adrenalectomized rats and it is preserved after the constitutive replacement by the corticosterone pellet, indicating that circulating glucocorticoid is not involved in the circadian regulation of CRH (Watts et al. 2004).
Regulation (regulation) of CRH
2) Confidence 0.51 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0
The role of the PKC pathway or AP1 proteins in CRH gene regulation is still controversial.
Regulation (regulation) of CRH gene associated with kinase c
3) Confidence 0.51 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.08 Pain Relevance 0.26
On the other hand, the dys-regulation of CRH in these regions probably causes depression or mood disorders (Stenzel-Poore et al. 1994; Risbrough and Stein, 2006).
Regulation (regulation) of CRH associated with depression and affective disorder
4) Confidence 0.51 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.71 Pain Relevance 0.15
There is an interesting report about the interaction of GR and a coactivator in the CRH gene regulation by glucocorticoid (van der Laan et al. in press).
Regulation (regulation) of CRH gene
5) Confidence 0.51 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0 Pain Relevance 0.16
Further, studies in humans indicate that dysregulation of CRF neurotransmission is linked to some forms of depression [18] and depression, itself, has been linked to decreases in maternal care [19].
Regulation (dysregulation) of CRF associated with depression
6) Confidence 0.48 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1821036 Disease Relevance 0.46 Pain Relevance 0.10
These results suggest that the specific unidirectional brain-to-blood transport system for CRH is dependent on energy and calcium channels, involves microtubules, is independent of the P-glycoprotein transporter, and is acutely modulated by adrenal steroids, cytokines, and endogenous opiates.
Regulation (modulated) of CRH in blood associated with calcium channel, opiate and cytokine
7) Confidence 0.45 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9124340 Disease Relevance 0.19 Pain Relevance 0.23
Acute modulation of active carrier-mediated brain-to-blood transport of corticotropin-releasing hormone.
Regulation (modulation) of corticotropin-releasing hormone in blood associated with cytokine
8) Confidence 0.45 Published 1997 Journal Am. J. Physiol. Section Title Doc Link 9124340 Disease Relevance 0.14 Pain Relevance 0.21
Effects of corticotropin-releasing hormone (CRH) on the synthesis and secretion of proopiomelanocortin-related peptides in the anterior pituitary: a study using CRH-deficient mice.
Regulation (Effects) of CRH in anterior pituitary associated with pain
9) Confidence 0.45 Published 2004 Journal Neurosci. Lett. Section Title Doc Link 15331153 Disease Relevance 0.15 Pain Relevance 0.18
Effects of corticotropin-releasing hormone (CRH) on the synthesis and secretion of proopiomelanocortin-related peptides in the anterior pituitary: a study using CRH-deficient mice.
Regulation (Effects) of corticotropin-releasing hormone in anterior pituitary associated with pain
10) Confidence 0.45 Published 2004 Journal Neurosci. Lett. Section Title Doc Link 15331153 Disease Relevance 0.15 Pain Relevance 0.18
Collectively, these results point to an important role of CRF and AVP in the regulation of dentate neurogenesis, and suggest that CRF(1) and V(1b) receptor antagonists may affect plasticity changes in the hippocampal formation, as do clinically effective antidepressants.
Spec (may) Regulation (affect) of CRF in hippocampal formation associated with antidepressant, antagonist and neurodegenerative disease
11) Confidence 0.45 Published 2004 Journal Mol. Psychiatry Section Abstract Doc Link 14699428 Disease Relevance 1.02 Pain Relevance 0.40
To study the modulatory effects of spinally administered CRF and dynorphin A on the expression of morphine tolerance, CRF and dynorphin A were injected i.t. at 15 min and 5 min, respectively, before testing the tolerant mice by the tail-flick assay.
Regulation (effects) of CRF in tail associated with dynorphin, tail-flick, tolerance and morphine
12) Confidence 0.44 Published 1992 Journal Life Sci. Section Abstract Doc Link 1352026 Disease Relevance 0 Pain Relevance 1.79
These data further support and validate findings obtained from animal models of alcohol addiction that dysregulation of the CRF system is underlies the development of alcohol addiction in humans.
Regulation (dysregulation) of CRF associated with addiction and alcohol
13) Confidence 0.40 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.37 Pain Relevance 0.66
Altogether, CRH and vasopressin are characterized as upstream regulators of the HPA axis.
Regulation (regulators) of CRH
14) Confidence 0.37 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.20 Pain Relevance 0
The physiological effect of CRH and related peptides such as Ucns is exerted via CRH receptors, which belong to the seven-transmembrane, G-protein coupled receptors (GPCR).
Regulation (effect) of CRH
15) Confidence 0.37 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.10 Pain Relevance 0.36
These electrophysiological data suggest that AC7 plays an important role in ethanol and CRF modulation of presynaptic GABA release in CeA and thus may underlie ethanol-related behaviors such as anxiety and dependence.



Regulation (modulation) of CRF in CeA associated with addiction, gaba, anxiety disorder and amygdala
16) Confidence 0.30 Published 2011 Journal Frontiers in Neuroscience Section Abstract Doc Link PMC3024005 Disease Relevance 0.10 Pain Relevance 0.38
In the present study, we examined the effects of CP-induced cystitis on the levels of mRNAs encoding galanin, corticotropin-releasing hormone (CRH), substance P, and enkephalins in the hypothalamic and limbic nuclei using in situ hybridization histochemistry in mouse.
Spec (examined) Regulation (effects) of CRH associated with cystitis, enkephalin and substance p
17) Confidence 0.27 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17335920 Disease Relevance 0.49 Pain Relevance 0.63
In the present study, we examined the effects of CP-induced cystitis on the levels of mRNAs encoding galanin, corticotropin-releasing hormone (CRH), substance P, and enkephalins in the hypothalamic and limbic nuclei using in situ hybridization histochemistry in mouse.
Spec (examined) Regulation (effects) of corticotropin-releasing hormone associated with cystitis, enkephalin and substance p
18) Confidence 0.27 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17335920 Disease Relevance 0.49 Pain Relevance 0.63
The effects of intracerebroventricular infusions of morphine, oxytocin, and corticotrophin-releasing factor (CRF) on maternal behaviour alone, or in conjunction with vaginocervical stimulation were determined in both nulliparous and multiparous ovariectomized ewes, primed with oestrogen for 3 days prior to testing.
Regulation (effects) of corticotrophin-releasing factor associated with intracerebroventricular and morphine
19) Confidence 0.23 Published 1991 Journal Brain Res. Section Abstract Doc Link 2054633 Disease Relevance 0 Pain Relevance 0.37
The effects of intracerebroventricular infusions of morphine, oxytocin, and corticotrophin-releasing factor (CRF) on maternal behaviour alone, or in conjunction with vaginocervical stimulation were determined in both nulliparous and multiparous ovariectomized ewes, primed with oestrogen for 3 days prior to testing.
Regulation (effects) of CRF associated with intracerebroventricular and morphine
20) Confidence 0.23 Published 1991 Journal Brain Res. Section Abstract Doc Link 2054633 Disease Relevance 0 Pain Relevance 0.37

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