INT75869

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Context Info
Confidence 0.45
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 27.76
Pain Relevance 3.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Acsl1) endoplasmic reticulum (Acsl1) plasma membrane (Acsl1)
peroxisome (Acsl1) ligase activity (Acsl1) lipid metabolic process (Acsl1)
Anatomy Link Frequency
lower body 1
neurons 1
lumen 1
mere 1
Acsl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 593 100.00 Very High Very High Very High
ischemia 166 100.00 Very High Very High Very High
Pain 16 99.46 Very High Very High Very High
rheumatoid arthritis 2 95.96 Very High Very High Very High
Dorsal horn 1 94.96 High High
Spinal cord 5 91.52 High High
anesthesia 2 87.12 High High
Dopamine 228 81.32 Quite High
Angina 29 80.64 Quite High
Inflammation 55 78.48 Quite High
Disease Link Frequency Relevance Heat
Depression 653 100.00 Very High Very High Very High
Acute Coronary Syndrome 255 100.00 Very High Very High Very High
Compartment Syndromes 84 100.00 Very High Very High Very High
Carotid Stenosis 50 100.00 Very High Very High Very High
Thrombosis 39 99.76 Very High Very High Very High
Anxiety Disorder 508 99.72 Very High Very High Very High
Pancreatitis 80 99.68 Very High Very High Very High
Hypertension 45 99.64 Very High Very High Very High
Hepatitis C Virus Infection 228 99.48 Very High Very High Very High
Pain 13 99.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
But, other atherosclerotic risk factors, such as smoking, hypertension, diabetes mellitusand hypercholesterolemia were not associated with the presence of ACAS.
Gene_expression (presence) of ACAS associated with nicotine addiction, diabetes mellitus, atherosclerosis, hypertension, hyperlipidemia and carotid stenosis
1) Confidence 0.45 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2908785 Disease Relevance 2.69 Pain Relevance 0.08
Therefore, preoperative CDUS is a useful screening tool to detect ACAS and to assess perioperative risk of cerebrovascular complications in PAD patients who undergo revascularization, particularly, in patients who are older than 65 yr or have a concomitant CAD.
Gene_expression (detect) of ACAS associated with coronary artery disease, peripheral arterial disease and carotid stenosis
2) Confidence 0.45 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2908785 Disease Relevance 1.55 Pain Relevance 0.15
Nine isoforms of cAMP-synthesizing enzymes called adenylyl-cyclases (ACs) and eleven phosphodiesterases (PDEs) that degrade cyclic nucleotides have been identified.
Gene_expression (called) of ACs
3) Confidence 0.39 Published 2010 Journal Brain Res. Section Abstract Doc Link 19913519 Disease Relevance 0 Pain Relevance 0.07
PAM (protein associated with Myc) is a potent inhibitor of adenylyl cyclases (ACs) which is primarily expressed in neurones.
Gene_expression (expressed) of ACs
4) Confidence 0.36 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14756816 Disease Relevance 0.20 Pain Relevance 0.17
CONCLUSIONS: The addition of BMIPP data to the initially available clinical information adds incremental value toward the early diagnosis of an ACS, potentially allowing determination of the presence or absence of ACS to be made earlier in the evaluation process.
Gene_expression (made) of ACS
5) Confidence 0.33 Published 2010 Journal J. Am. Coll. Cardiol. Section Body Doc Link 20633821 Disease Relevance 0 Pain Relevance 0
So far, there have not been standard recommendations for a surgical or some other interventional treatment of patients who develop ACS during the course of SAP [14].
Gene_expression (develop) of ACS associated with compartment syndromes and pancreatitis
6) Confidence 0.26 Published 2010 Journal BMC Surg Section Body Doc Link PMC2913911 Disease Relevance 2.01 Pain Relevance 0
Some procedures have been occasionally reported that could be useful and may be able to improve outcome of patients who develop ACS during SAP.
Gene_expression (develop) of ACS associated with compartment syndromes and pancreatitis
7) Confidence 0.26 Published 2010 Journal BMC Surg Section Body Doc Link PMC2913911 Disease Relevance 1.83 Pain Relevance 0
Total RNA were prepared from the uteri of each subject, and expression of ACs was analyzed by reverse transcription-polymerase chain reaction (RT-PCR).
Spec (analyzed) Gene_expression (expression) of ACs
8) Confidence 0.24 Published 2005 Journal J. Endocrinol. Invest. Section Abstract Doc Link 15966510 Disease Relevance 0 Pain Relevance 0.09
In our view the readout of convergence on the MAPKs level might be a mere expression of the convergence on the ACs.
Gene_expression (expression) of ACs in mere
9) Confidence 0.07 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0.09 Pain Relevance 0.06
Individuals who were HCV-negative at ACS entry were tested for HCV antibodies at their last ACS visit before November 2005.
Gene_expression (visit) of ACS associated with hepatitis c virus infection
10) Confidence 0.07 Published 2009 Journal Journal of Viral Hepatitis Section Body Doc Link PMC2759985 Disease Relevance 1.10 Pain Relevance 0
All ACS samples were stored at ?
Gene_expression (samples) of ACS
11) Confidence 0.07 Published 2009 Journal Journal of Viral Hepatitis Section Body Doc Link PMC2759985 Disease Relevance 1.37 Pain Relevance 0
One day after unilateral ablation of the ACs, c-Fos expression in IC neurons induced by acoustic stimulation, is diminished.
Gene_expression (expression) of ACs in neurons
12) Confidence 0.06 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2981384 Disease Relevance 0 Pain Relevance 0
Classically, adenylyl cyclases (ACs), especially AC1 and AC8 are proposed to serve as molecular coincident detectors in this convergence phenomena [15].
Gene_expression (proposed) of ACs
13) Confidence 0.06 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762427 Disease Relevance 0.20 Pain Relevance 0.16
Each year, more than one million Americans suffer an ACS.14 Risk factors for having cardiac disease, and ultimately an ACS, include gender (men are slightly more likely to have cardiac illness), age (men over 45 years and women over 55 years), family history of cardiovascular disease, and modifiable risk factors.14 ACS is more common in men (eg, 58% of all ACS events occurred in men in 2005), though ACS prevalence in women approaches that of men in older age.14 Modifiable risk factors for an ACS include hypertension, hyperlipidemia, diabetes, sedentary lifestyle, and smoking.
Gene_expression (prevalence) of ACS associated with acute coronary syndrome, nicotine addiction, diabetes mellitus, cardiovascular disease, heart disease, hypertension and hyperlipidemia
14) Confidence 0.06 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874336 Disease Relevance 3.03 Pain Relevance 0.54
Although ACAs were more likely to be present in a subset of patients without systemic lupus erythematosus (SLE) and/or the LAC, their presence was a poor discriminator of increased risk of thrombosis.
Gene_expression (present) of ACAs associated with systemic lupus erythematosus and thrombosis
15) Confidence 0.05 Published 1998 Journal Thromb. Res. Section Abstract Doc Link 9622037 Disease Relevance 1.27 Pain Relevance 0.13
IgA ACAs were present in high titers in all groups and had little discriminant value in predicting thrombotic risk.
Gene_expression (present) of ACAs
16) Confidence 0.05 Published 1998 Journal Thromb. Res. Section Abstract Doc Link 9622037 Disease Relevance 0.80 Pain Relevance 0.08
Each year, more than one million Americans suffer an ACS.14 Risk factors for having cardiac disease, and ultimately an ACS, include gender (men are slightly more likely to have cardiac illness), age (men over 45 years and women over 55 years), family history of cardiovascular disease, and modifiable risk factors.14 ACS is more common in men (eg, 58% of all ACS events occurred in men in 2005), though ACS prevalence in women approaches that of men in older age.14 Modifiable risk factors for an ACS include hypertension, hyperlipidemia, diabetes, sedentary lifestyle, and smoking.
Gene_expression (prevalence) of ACS associated with acute coronary syndrome, nicotine addiction, diabetes mellitus, cardiovascular disease, heart disease, hypertension and hyperlipidemia
17) Confidence 0.05 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874336 Disease Relevance 3.17 Pain Relevance 0.54
Indeed, it is now recognized that the great majority of coronary atherosclerotic plaques that lead to ACS are typically relatively nonobstructive prior to the ACS, with a predisposition to rupture that is determined more by their intrinsic biology, than degree of protrusion into the coronary lumen.17
Gene_expression (nonobstructive) of ACS in lumen associated with acute coronary syndrome, atherosclerotic plaque and rupture
18) Confidence 0.05 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874336 Disease Relevance 1.96 Pain Relevance 0.16
A recent longitudinal study of post-ACS depression found that baseline depression severity a few weeks after ACS was a strong and independent risk factor for cardiac mortality approximately 7 years after the index event.52 Findings from this study and others indicate that ACS patients whose depression is resistant to standard treatments appear to be at highest risk of suffering adverse cardiac outcomes.52–54 It is unclear whether this is because the depression persists or whether this is a separate subtype of depression.
Gene_expression (depression) of ACS associated with depression and ischemia
19) Confidence 0.05 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874336 Disease Relevance 2.27 Pain Relevance 0.87
As with depression, clinically significant anxiety in post-ACS patients often goes unrecognized and untreated by front-line clinicians on cardiac inpatient units.2 Follow-up of patients with these symptoms is equally limited; in one study, roughly one third of patients who had elevated anxiety following an ACS were questioned about these symptoms by their medical clinicians over the next year.1

Links between depression, anxiety, and negative cardiac outcomes among patients suffering acute ischemic events

Gene_expression (questioned) of ACS associated with acute coronary syndrome, depression and anxiety disorder
20) Confidence 0.05 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2874336 Disease Relevance 2.13 Pain Relevance 0.20

General Comments

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