INT7587

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Context Info
Confidence 0.78
First Reported 1986
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 27
Total Number 30
Disease Relevance 4.79
Pain Relevance 14.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (GAL) Golgi apparatus (GAL) cellular_component (GAL)
response to stress (GAL) cytoplasm (GAL)
Anatomy Link Frequency
neurons 3
stellate ganglion 2
hypothalamus 2
pituitary 2
central nervous system 1
GAL (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 311 100.00 Very High Very High Very High
Enkephalin 67 100.00 Very High Very High Very High
substance P 59 100.00 Very High Very High Very High
Somatostatin 21 100.00 Very High Very High Very High
Calcitonin gene-related peptide 15 100.00 Very High Very High Very High
Cholecystokinin 10 100.00 Very High Very High Very High
calcitonin gene related peptide 7 100.00 Very High Very High Very High
gABA 18 99.98 Very High Very High Very High
Central nervous system 13 99.96 Very High Very High Very High
Clonidine 7 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 11 99.74 Very High Very High Very High
Hypoglycemia 1 99.16 Very High Very High Very High
Pain 17 97.20 Very High Very High Very High
Increased Venous Pressure Under Development 2 97.20 Very High Very High Very High
Ganglion Cysts 30 97.00 Very High Very High Very High
Natriuresis 2 96.24 Very High Very High Very High
Arthropathy 1 93.64 High High
INFLAMMATION 1 93.08 High High
Galactorrhea 124 84.96 Quite High
Disease 25 83.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antibody microprobe studies of the spinal release of ir-galanin have favored release from intrinsic spinal neurons rather than from primary afferent terminals following peripheral noxious stimuli.
Localization (release) of galanin in neurons
1) Confidence 0.78 Published 1994 Journal Front Neuroendocrinol Section Abstract Doc Link 7859915 Disease Relevance 0.26 Pain Relevance 0.72
Neuropeptides like substance P, dynorphin A and B, cholecystokinin, galanin, corticotropin-releasing factor, thyrotropin-releasing hormone, angiotensin II and neurotensin showed no immunoreactivity in the human superior cervical ganglion.
Localization (releasing) of galanin in superior cervical ganglion associated with ganglion cysts, dynorphin, neuropeptide, cholecystokinin and substance p
2) Confidence 0.73 Published 1992 Journal Brain Res. Section Abstract Doc Link 1352173 Disease Relevance 0.42 Pain Relevance 0.60
A number of other neurotrasmitters and neuropeptides can also modulate prolactin secretion, among which galanin, endothelin, TGFbeta1, angiotensin, somatostatin, substance P, neurotensin, calcitonin, EGF, natriuretic atrial peptide, bombesin, colecistokinine, acetylcholine, vasopressin (Figure 1).
Localization (secretion) of galanin associated with natriuresis, somatostatin, neuropeptide and substance p
3) Confidence 0.73 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.27 Pain Relevance 0.27
To investigate the possible mechanism leading to the decrease in GH secretion by specific activation of delta-opioidergic pathway in man, we compared, in normal subjects, the effect of DT on GH secretion responses to two different GH secretagogues, namely arginine (ARG) and galanin (GAL).
Localization (secretagogues) of galanin
4) Confidence 0.73 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 8570858 Disease Relevance 0 Pain Relevance 0.21
To investigate the possible mechanism leading to the decrease in GH secretion by specific activation of delta-opioidergic pathway in man, we compared, in normal subjects, the effect of DT on GH secretion responses to two different GH secretagogues, namely arginine (ARG) and galanin (GAL).
Localization (secretion) of GAL
5) Confidence 0.73 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 8570858 Disease Relevance 0 Pain Relevance 0.21
To investigate the possible mechanism leading to the decrease in GH secretion by specific activation of delta-opioidergic pathway in man, we compared, in normal subjects, the effect of DT on GH secretion responses to two different GH secretagogues, namely arginine (ARG) and galanin (GAL).
Localization (secretagogues) of GAL
6) Confidence 0.73 Published 1995 Journal Regul. Pept. Section Abstract Doc Link 8570858 Disease Relevance 0 Pain Relevance 0.21
Peptides present in the gut and lung innervation include: vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI), galanin, substance P, calcitonin gene-related peptide (CGRP), neuropeptide tyrosine (NPY), somatostatin and cholecystokinin (the latter two are also localised to endocrine cells of the gut).
Localization (localised) of galanin in gut associated with somatostatin, neuropeptide, cholecystokinin, calcitonin gene-related peptide and substance p
7) Confidence 0.73 Published 1986 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2425759 Disease Relevance 0.07 Pain Relevance 0.42
The Authors analyse the main body of somatotropin function test: insulin hypoglycemia; arginine; ornithine; I-dopa; clonidine; galanin; GH-RH; physical exercise; sleep; combined stimuli; spontaneous GH secretion of varying duration.
Localization (secretion) of galanin in body associated with hypoglycemia and clonidine
8) Confidence 0.73 Published 1989 Journal J. Endocrinol. Invest. Section Abstract Doc Link 2681353 Disease Relevance 0.10 Pain Relevance 0.10
In addition, there are studies reporting the occurrence of putative neurotransmitters such as cholecystokinin, dynorphin B, galanin, gastrin releasing peptide, vasopressin, neurotensin, and somatostatin.
Localization (releasing) of galanin associated with neurotransmitter, dynorphin, somatostatin and cholecystokinin
9) Confidence 0.68 Published 1989 Journal Cerebrovasc Brain Metab Rev Section Abstract Doc Link 2701377 Disease Relevance 0.18 Pain Relevance 0.47
Furthermore, based on paired pulse facilitation studies, we show that Gal 1-29 likely decreases GABA release through a presynaptic mechanism, whereas Gal 2-11 may act postsynaptically.
Localization (release) of Gal associated with gaba
10) Confidence 0.68 Published 2008 Journal Neurochem. Res. Section Abstract Doc Link 17973188 Disease Relevance 0 Pain Relevance 0.47
The neuropeptide galanin has important effects on hormone secretion from the hypothalamus and pituitary, and it may also be involved in central biological processes such as pain, memory, and food intake.
Localization (secretion) of galanin in hypothalamus associated with pain and neuropeptide
11) Confidence 0.68 Published 2005 Journal Neuropeptides Section Abstract Doc Link 15944032 Disease Relevance 0.10 Pain Relevance 0.15
The neuroactive substances localized immunohistochemically in the NTS include acetylcholine, the neuropeptides, substance P, methionine- and leucine-enkephalin, beta-endorphin, cholecystokinin, neurotensin, galanin, calcitonin gene-related peptide, somatostatin, FMRMamide, neuropeptide Y, angiotensin II, vasoactive intestinal polypeptide, vasopressin, oxytocin, thyrotropin-releasing hormone, luteinizing hormone-releasing hormone, atrial natriuretic peptide, the catecholamines, dopamine, norepinephrine, epinephrine, serotonin, histamine and the amino acids, GABA and glutamate.
Localization (localized) of galanin associated with natriuresis, dopamine, catecholamine, somatostatin, enkephalin, calcitonin gene-related peptide, glutamate, gaba, neuropeptide, cholecystokinin, serotonin and substance p
12) Confidence 0.68 Published 1996 Journal Chem. Senses Section Abstract Doc Link 8670716 Disease Relevance 0.09 Pain Relevance 1.03
Other neuropeptides have been isolated, including galanin, neuropeptide Y, bombesin, gastrin releasing peptide, enkephalins and katacalcin.
Localization (releasing) of galanin associated with neuropeptide and enkephalin
13) Confidence 0.68 Published 1989 Journal Rev Pneumol Clin Section Abstract Doc Link 2576326 Disease Relevance 0.15 Pain Relevance 0.70
Galanin, a neuropeptide, has important effects on hormone secretion from the hypothalamus and pituitary, and may also be involved in important biological processes such as pain, memory, and food intake.
Localization (secretion) of Galanin in pituitary associated with pain and neuropeptide
14) Confidence 0.66 Published 2005 Journal Horm. Metab. Res. Section Abstract Doc Link 15971152 Disease Relevance 0.10 Pain Relevance 0.15
In the present study, the localization of GMAP in dorsal root ganglia, dorsal roots and dorsal horn was analyzed immunohistochemically and compared between rats with intact and sectioned sciatic nerves.
Spec (analyzed) Localization (localization) of GMAP in dorsal root ganglia associated with dorsal horn and sciatic nerve
15) Confidence 0.66 Published 1995 Journal Neuropeptides Section Abstract Doc Link 7603589 Disease Relevance 0.17 Pain Relevance 0.46
In the central nervous system, galanin alters the release of several neurotransmitters.
Localization (release) of galanin in central nervous system associated with neurotransmitter and central nervous system
16) Confidence 0.64 Published 2002 Journal Curr Drug Targets CNS Neurol Disord Section Abstract Doc Link 12769595 Disease Relevance 0.29 Pain Relevance 0.14
We have evaluated the effect of galanin (Gal), a newly identified hypothalamic peptide, on growth hormone (GH) secretion in 10 children with normal stature (NS), nine with constitutional growth delay (CGD), and five with isolated GH deficiency (IGHD).
Localization (secretion) of galanin
17) Confidence 0.56 Published 1989 Journal Pediatr. Res. Section Abstract Doc Link 2477790 Disease Relevance 0.07 Pain Relevance 0.08
We have evaluated the effect of galanin (Gal), a newly identified hypothalamic peptide, on growth hormone (GH) secretion in 10 children with normal stature (NS), nine with constitutional growth delay (CGD), and five with isolated GH deficiency (IGHD).
Localization (secretion) of Gal
18) Confidence 0.56 Published 1989 Journal Pediatr. Res. Section Abstract Doc Link 2477790 Disease Relevance 0.07 Pain Relevance 0.08
The localization of some neuropeptides including neuropeptide Y (NPY), substance P (SP), calcitonin gene related peptide (CGRP), vasoactive intestinal peptide (VIP), galanin (Gal), methionine enkephalin (M-ENK), tyrosine hydroxylase (TH) immunoreactivity was studied in the stellate ganglion (SG) of water buffalo.
Localization (localization) of galanin in stellate ganglion associated with ganglion cysts, calcitonin gene related peptide, neuropeptide, enkephalin and substance p
19) Confidence 0.41 Published 2000 Journal Fukuoka Igaku Zasshi Section Abstract Doc Link 10916853 Disease Relevance 0.42 Pain Relevance 0.60
The localization of some neuropeptides including neuropeptide Y (NPY), substance P (SP), calcitonin gene related peptide (CGRP), vasoactive intestinal peptide (VIP), galanin (Gal), methionine enkephalin (M-ENK), tyrosine hydroxylase (TH) immunoreactivity was studied in the stellate ganglion (SG) of water buffalo.
Localization (localization) of Gal in stellate ganglion associated with ganglion cysts, calcitonin gene related peptide, neuropeptide, enkephalin and substance p
20) Confidence 0.41 Published 2000 Journal Fukuoka Igaku Zasshi Section Abstract Doc Link 10916853 Disease Relevance 0.42 Pain Relevance 0.60

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