INT75871

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Context Info
Confidence 0.53
First Reported 1998
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 1.34
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Npy1r) plasma membrane (Npy1r) molecular_function (Npy1r)
signal transducer activity (Npy1r)
Anatomy Link Frequency
arcuate nucleus 3
blood 2
MPN 1
Npy1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 14 99.76 Very High Very High Very High
antagonist 6 99.20 Very High Very High Very High
agonist 3 94.52 High High
Intracerebroventricular 3 88.44 High High
opioid receptor 3 75.00 Quite High
Endogenous opioid 3 74.96 Quite High
mu opioid receptor 3 66.04 Quite High
Enkephalin 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 9 100.00 Very High Very High Very High
Lordosis 9 89.20 High High
Aging 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Y1R antagonist (Cys31, Nva34)-Neuropeptide Y (27-36)2 prevented estrogen-induced Y1R and MOR activation/internalization.
Negative_regulation (prevented) of Positive_regulation (induced) of Y1R associated with antagonist and neuropeptide
1) Confidence 0.53 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14749439 Disease Relevance 0.15 Pain Relevance 0.49
NPY reversed the progesterone blockade of estradiol-induced Y1R and MOR internalization in the arcuate nucleus and MPN, respectively.
Negative_regulation (blockade) of Positive_regulation (induced) of Y1R in arcuate nucleus
2) Confidence 0.39 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14749439 Disease Relevance 0.16 Pain Relevance 0.47
NPY reversed the progesterone blockade of estradiol-induced Y1R and MOR internalization in the arcuate nucleus and MPN, respectively.
Negative_regulation (blockade) of in MPN Positive_regulation (induced) of Y1R in arcuate nucleus
3) Confidence 0.13 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14749439 Disease Relevance 0.16 Pain Relevance 0.47
We observed that the induction by stress of adrenal NPY mRNA is impaired with age but the stress-induced elevation of adrenal ppENK mRNA, blood glucose, and corticosterone show no evidence of age-related impairments.
Negative_regulation (impaired) of Positive_regulation (induction) of NPY mRNA in blood associated with stress
4) Confidence 0.09 Published 1998 Journal Mech. Ageing Dev. Section Abstract Doc Link 9622227 Disease Relevance 0.87 Pain Relevance 0.08

General Comments

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