INT7588

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Context Info
Confidence 0.44
First Reported 1986
Last Reported 2011
Negated 2
Speculated 2
Reported most in Abstract
Documents 13
Total Number 15
Disease Relevance 6.97
Pain Relevance 7.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (NPY) extracellular space (NPY) extracellular region (NPY)
cell (NPY)
Anatomy Link Frequency
neuron 3
eyes 1
Plasma 1
hypothalamus 1
NPY (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 61 100.00 Very High Very High Very High
substance P 53 100.00 Very High Very High Very High
Calcitonin gene-related peptide 35 100.00 Very High Very High Very High
qutenza 12 100.00 Very High Very High Very High
Serotonin 3 100.00 Very High Very High Very High
headache 5 99.84 Very High Very High Very High
noradrenaline 6 99.72 Very High Very High Very High
Fibrositis 10 99.68 Very High Very High Very High
antagonist 21 99.62 Very High Very High Very High
Somatostatin 17 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 5 99.84 Very High Very High Very High
Cancer 18 99.76 Very High Very High Very High
Sleep Disorders 10 99.68 Very High Very High Very High
Hyperphagia 2 99.40 Very High Very High Very High
Ganglion Cysts 4 95.52 Very High Very High Very High
Cystitis 1 95.40 Very High Very High Very High
Pain 2 94.96 High High
Alzheimer's Dementia 14 94.80 High High
Stress 25 93.20 High High
Necrosis 3 90.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, neuroleptics also alter the biochemical integrity of neurotensin, neuropeptide Y, substance P and somatostatin, which may also play a role in the overall expression of the neuroleptic-induced extrapyramidal reactions.
Regulation (alter) of neuropeptide Y associated with somatostatin, neuropeptide and substance p
1) Confidence 0.44 Published 1988 Journal Neurosci Biobehav Rev Section Abstract Doc Link 2906420 Disease Relevance 0.47 Pain Relevance 0.78
NPY and CGRP immunoreactivities were found in some TH-positive cells, but that co-localization never exceeded the 30% of the TH cells.
Regulation (immunoreactivities) of NPY associated with calcitonin gene-related peptide
2) Confidence 0.26 Published 1992 Journal Brain Res. Section Abstract Doc Link 1352173 Disease Relevance 0.34 Pain Relevance 0.61
The argyrophilic tumor cells with occasional mitoses and focal venous involvement predominantly showed immunoreactivity of cytokeratin, neuron-specific enolase, cystatin C, chromogranin A, calcitonin and neuropeptide Y (NPY).
Regulation (immunoreactivity) of NPY in neuron associated with cancer and neuropeptide
3) Confidence 0.26 Published 1992 Journal Acta Pathol. Jpn. Section Abstract Doc Link 1609616 Disease Relevance 0.88 Pain Relevance 0.41
The argyrophilic tumor cells with occasional mitoses and focal venous involvement predominantly showed immunoreactivity of cytokeratin, neuron-specific enolase, cystatin C, chromogranin A, calcitonin and neuropeptide Y (NPY).
Regulation (immunoreactivity) of neuropeptide Y in neuron associated with cancer and neuropeptide
4) Confidence 0.26 Published 1992 Journal Acta Pathol. Jpn. Section Abstract Doc Link 1609616 Disease Relevance 0.88 Pain Relevance 0.41
There was a significant difference between FM and TTH versus controls in NPY levels, but not in APA levels.
Regulation (controls) of NPY associated with headache and fibrositis
5) Confidence 0.26 Published 2010 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 20398011 Disease Relevance 1.37 Pain Relevance 1.19
In contrast to the response to noradrenaline (NA) and K+, the NPY effect was not altered by changes in the extracellular Ca++ concentration.
Neg (not) Regulation (altered) of NPY associated with noradrenaline
6) Confidence 0.25 Published 1988 Journal J. Neurosurg. Section Abstract Doc Link 2461438 Disease Relevance 0 Pain Relevance 0.85
No significant changes were observed at baseline and after CPT in SP, CGRP, NPY, and VIP tear levels between eyes challenged with allergen and eyes challenged with diluent.
Regulation (changes) of NPY in eyes associated with substance p
7) Confidence 0.25 Published 2011 Journal Molecular Vision Section Body Doc Link PMC3021574 Disease Relevance 0.16 Pain Relevance 0.36
After RU 486 treatment, however, there was a tendency towards a decrease of NPY- and VIP-immunoreactivity, and an increase of CGRP-immunoreactivity.
Regulation (immunoreactivity) of NPY associated with calcitonin gene-related peptide
8) Confidence 0.24 Published 1990 Journal Hum. Reprod. Section Abstract Doc Link 1702449 Disease Relevance 0.09 Pain Relevance 0.56
In addition to positive carcinoembryonic antigen and cytokeratin, the argyrophilic cancer cells were immunoreactive for neuron-specific enolase, chromogranin A, serotonin, neuropeptide Y, glicentin, somatostatin, neurotensin and calcitonin.
Regulation (immunoreactive) of neuropeptide Y in neuron associated with cancer, somatostatin, neuropeptide and serotonin
9) Confidence 0.19 Published 1991 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 1942551 Disease Relevance 1.18 Pain Relevance 0.22
Cortisol may influence the reward value of food via neuroendocrine/peptide mediators such as leptin, insulin and neuropeptide Y (NPY).
Spec (may) Regulation (influence) of neuropeptide Y associated with neuropeptide
10) Confidence 0.19 Published 2007 Journal Physiol. Behav. Section Abstract Doc Link 17543357 Disease Relevance 1.21 Pain Relevance 0.25
Effects of neuropeptide Y, calcitonin gene-related peptide, substance P, and capsaicin on cerebral arteries in man and animals.
Regulation (Effects) of neuropeptide Y associated with qutenza, neuropeptide, substance p and calcitonin gene-related peptide
11) Confidence 0.18 Published 1988 Journal J. Neurosurg. Section Title Doc Link 2461438 Disease Relevance 0 Pain Relevance 0.98
In rats, a postmortem delay of up to 8 hours did not affect SP, Met-Enk, PHI, or NPY and decreased SST, CCK, and VIP levels.
Neg (not) Regulation (affect) of NPY associated with somatostatin, cholecystokinin and substance p
12) Confidence 0.15 Published 1990 Journal Neurology Section Abstract Doc Link 2296359 Disease Relevance 0.17 Pain Relevance 0.77
Plasma leptin and ghrelin concentrations tend to vary inversely in various clinical settings [364], and CNS leptin is a strong ghrelin antagonist [35], possibly by modulating NPY-Y1 or Y5 signaling [8, 38].
Spec (possibly) Regulation (modulating) of NPY in Plasma associated with antagonist
13) Confidence 0.09 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.21 Pain Relevance 0.08
Based on the evidence summarized here we propose that gonadal steroids may exert a "trophic" influence on the regulatory peptides namely LHRH, NPY and EOP locally in the hypothalamus.
Regulation (influence) of NPY in hypothalamus
14) Confidence 0.05 Published 1986 Journal J. Steroid Biochem. Section Abstract Doc Link 3543500 Disease Relevance 0 Pain Relevance 0.20
Sensitivity of orexin-A binding to phospholipase C inhibitors, neuropeptide Y, and secretin.
Regulation (Sensitivity) of neuropeptide Y associated with neuropeptide
15) Confidence 0.04 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 10860858 Disease Relevance 0 Pain Relevance 0.31

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