INT75907

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Context Info
Confidence 0.46
First Reported 1998
Last Reported 2010
Negated 1
Speculated 7
Reported most in Body
Documents 53
Total Number 60
Disease Relevance 46.65
Pain Relevance 8.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEP) extracellular region (LEP) lipid metabolic process (LEP)
Anatomy Link Frequency
plasma 7
hypothalamus 4
muscles 3
lung 2
Peritoneal fluid 2
LEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 729 100.00 Very High Very High Very High
cytokine 138 100.00 Very High Very High Very High
Neuropeptide 49 100.00 Very High Very High Very High
Osteoarthritis 337 99.92 Very High Very High Very High
Endocannabinoid 37 99.84 Very High Very High Very High
Migraine 3 99.76 Very High Very High Very High
Pain 168 99.66 Very High Very High Very High
pain pelvic 5 99.44 Very High Very High Very High
nud 83 99.26 Very High Very High Very High
tolerance 17 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 2307 100.00 Very High Very High Very High
INFLAMMATION 887 100.00 Very High Very High Very High
Metabolic Syndrome 297 100.00 Very High Very High Very High
Loss Of Sense Of Smell 291 100.00 Very High Very High Very High
Osteoarthritis 330 99.92 Very High Very High Very High
Body Weight 231 99.76 Very High Very High Very High
Reprotox - General 3 57 99.76 Very High Very High Very High
Headache 12 99.76 Very High Very High Very High
Coronary Artery Disease 10 99.76 Very High Very High Very High
Gastritis 3 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the association of leptin with infertility has not been definitely documented.
leptin Binding (association) of associated with reprotox - general 3
1) Confidence 0.46 Published 2008 Journal Gynecol. Endocrinol. Section Abstract Doc Link 18958774 Disease Relevance 0.97 Pain Relevance 0.33
Peritoneal fluid leptin is associated with chronic pelvic pain but not infertility in endometriosis patients.
leptin Binding (associated) of in Peritoneal fluid associated with endometriosis, reprotox - general 3, inflammation and pain pelvic
2) Confidence 0.45 Published 2006 Journal Hum. Reprod. Section Title Doc Link 16269446 Disease Relevance 0.30 Pain Relevance 0.34
Leptin circulates in the plasma in a free-form state or bound to leptin-binding proteins [11].
Leptin Binding (bound) of in plasma
3) Confidence 0.36 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2567288 Disease Relevance 1.19 Pain Relevance 0.12
Since human CRP correlates with increased plasma leptin and adiposity, the results "suggest a potential mechanism to leptin resistance, by which circulating CRP binds to leptin and attenuates its physiological functions [16].
leptin Binding (circulating) of in plasma
4) Confidence 0.36 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2836327 Disease Relevance 0.46 Pain Relevance 0.07
LeptiCore's ability to lower CRP levels allows the remaining circulating leptin to reside in its "free" state and bind to appetite-regulating leptin receptors in the hypothalamus.
leptin Binding (bind) of in hypothalamus
5) Confidence 0.36 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2836327 Disease Relevance 0.82 Pain Relevance 0.13
In vivo and in vitro research done at the University of Pittsburgh demonstrated that CRP binds to leptin thereby impairing its signaling in two ways: 1) the coupling of CRP to leptin makes crossing the blood-brain barrier nearly impossible, thus preventing "free" leptin access to the hypothalamus; 2) the CRP/leptin complex inhibits the binding of leptin to its receptors, thus blocking its ability to signal in cultured cells.
leptin Binding (binding) of in hypothalamus
6) Confidence 0.36 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2836327 Disease Relevance 0.56 Pain Relevance 0.08
In one set of studies, the researchers delivered human leptin continuously for six days into mice which had receptors for leptin but lacked the ability to produce it.
leptin Binding (receptors) of
7) Confidence 0.36 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2836327 Disease Relevance 0.45 Pain Relevance 0.06
Leptin links the
Leptin Binding (links) of
8) Confidence 0.35 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 1.26 Pain Relevance 0.27
Nevertheless, only a few studies analyzed associations between lung function impairment and circulatory leptin.
leptin Spec (analyzed) Binding (associations) of in lung
9) Confidence 0.35 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 1.37 Pain Relevance 0.15
In conclusion, OA cartilage was shown to respond to leptin by producing increased amounts of NO, PGE2, IL-6, IL-8, and all those effects can be considered harmful in cartilage metabolism.
leptin Binding (respond) of in cartilage associated with osteoarthritis
10) Confidence 0.35 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2726438 Disease Relevance 0.51 Pain Relevance 0.35
In vivo and in vitro research done at the University of Pittsburgh demonstrated that CRP binds to leptin thereby impairing its signaling in two ways: 1) the coupling of CRP to leptin makes crossing the blood-brain barrier nearly impossible, thus preventing "free" leptin access to the hypothalamus; 2) the CRP/leptin complex inhibits the binding of leptin to its receptors, thus blocking its ability to signal in cultured cells.
leptin Binding (binding) of in hypothalamus
11) Confidence 0.34 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2836327 Disease Relevance 0.56 Pain Relevance 0.08
LeptiCore's ability to lower CRP levels allows the remaining circulating leptin to reside in its "free" state and bind to appetite-regulating leptin receptors in the hypothalamus.
leptin Binding (bind) of in hypothalamus
12) Confidence 0.34 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2836327 Disease Relevance 0.86 Pain Relevance 0.13
For

instance, for the LEP-N150 (or LEP-P200), according to its time-frequency map,

LEP-N150 Binding (according) of
13) Confidence 0.34 Published 2007 Journal Computational Intelligence and Neuroscience Section Body Doc Link PMC2271124 Disease Relevance 0 Pain Relevance 0
Serum adiponectin, leptin, and insulin concentrations were determined by radioimmunoassay.
leptin Spec (determined) Binding (determined) of
14) Confidence 0.33 Published 2009 Journal J. Clin. Gastroenterol. Section Body Doc Link 18827713 Disease Relevance 0.15 Pain Relevance 0
Perhaps they had not yet encountered a patient with LEP or were actually uncertain about the session's usefulness.
LEP Neg (not) Binding (patient) of
15) Confidence 0.33 Published 2009 Journal Medical Education Online Section Body Doc Link PMC2779621 Disease Relevance 0 Pain Relevance 0
We determined the central interactions of neuropeptide Y and leptin on cardiovascular and sympathetic responses in conscious rabbits.
leptin Spec (determined) Binding (interactions) of in sympathetic associated with neuropeptide
16) Confidence 0.33 Published 2000 Journal Hypertension Section Abstract Doc Link 11116122 Disease Relevance 0 Pain Relevance 0.27
Growing body of evidence suggests that leptin may have an important role in up-regulating the inflammatory system: not only does TNF-?
leptin Binding (only) of in body associated with inflammation
17) Confidence 0.31 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 1.56 Pain Relevance 0.13
The results of this study suggest that, in men, leptin may be associated with risk of colorectal adenomas.
leptin Binding (associated) of associated with adenoma
18) Confidence 0.30 Published 2007 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 18086776 Disease Relevance 1.03 Pain Relevance 0.08
A significant group × time interaction was found for serum leptin (P < 0.05), with significant reductions occurring after the initial phase of dietary restriction.
serum leptin Binding (interaction) of
19) Confidence 0.29 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2693519 Disease Relevance 0.52 Pain Relevance 0
For

instance, for the LEP-N150 (or LEP-P200), according to its time-frequency map,

LEP-P200 Binding (according) of
20) Confidence 0.29 Published 2007 Journal Computational Intelligence and Neuroscience Section Body Doc Link PMC2271124 Disease Relevance 0 Pain Relevance 0

General Comments

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