INT75908

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Context Info
Confidence 0.60
First Reported 1998
Last Reported 2010
Negated 11
Speculated 8
Reported most in Body
Documents 77
Total Number 85
Disease Relevance 60.16
Pain Relevance 15.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEP) extracellular region (LEP) lipid metabolic process (LEP)
Anatomy Link Frequency
plasma 7
chondrocytes 3
body 3
hypothalamus 3
blood 2
LEP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 118 100.00 Very High Very High Very High
Serotonin 39 100.00 Very High Very High Very High
Inflammatory mediators 27 100.00 Very High Very High Very High
Opioid 15 100.00 Very High Very High Very High
fluoxetine 11 100.00 Very High Very High Very High
Endep 10 100.00 Very High Very High Very High
spinal inflammation 12 99.84 Very High Very High Very High
Inflammation 226 99.80 Very High Very High Very High
Pain 190 99.76 Very High Very High Very High
rheumatoid arthritis 22 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 2080 100.00 Very High Very High Very High
Diabetes Mellitus 326 100.00 Very High Very High Very High
INFLAMMATION 274 100.00 Very High Very High Very High
Metabolic Syndrome 247 100.00 Very High Very High Very High
Insulin Resistance 111 100.00 Very High Very High Very High
Weight Gain 76 100.00 Very High Very High Very High
Ulcers 13 100.00 Very High Very High Very High
Stress 95 99.96 Very High Very High Very High
Enteropathy 2 99.90 Very High Very High Very High
Low Back Pain 16 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the effects of total abdominal hysterectomy on circulating leptin levels, 16 pre- and 8 postmenopausal patients with uterine leiomyoma or carcinoma in situ of the uterine cervix were enrolled.
Spec (investigate) Regulation (effects) of leptin in uterine associated with reprotox - general 3 and carcinoma in situ
1) Confidence 0.60 Published 2001 Journal Endocr. J. Section Abstract Doc Link 11603576 Disease Relevance 0.43 Pain Relevance 0.08
Perioperative changes in circulating leptin levels in women undergoing total abdominal hysterectomy.
Regulation (changes) of leptin
2) Confidence 0.60 Published 2001 Journal Endocr. J. Section Title Doc Link 11603576 Disease Relevance 0.54 Pain Relevance 0.08
LeptiCore's efficacy may also be due to the fact that it effects a time-dependent transit through the gastro-intestinal tract which, in turn, elicits a signal to regulate leptin levels.
Regulation (regulate) of leptin
3) Confidence 0.59 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2836327 Disease Relevance 0.88 Pain Relevance 0.18
An influence of steroid treatment on the serum leptin level was not shown.
Regulation (influence) of serum leptin
4) Confidence 0.54 Published 2007 Journal Rheumatol. Int. Section Abstract Doc Link 17443329 Disease Relevance 1.73 Pain Relevance 0.59
In another study, the beta-blocker (BB) pindolol showed a marked suppressive effect on serum leptin levels, not seen in hypertensive individuals on perindopril, or felodipine (Ficek et al 2002).
Regulation (effect) of serum leptin associated with beta blocker and hypertension
5) Confidence 0.53 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993994 Disease Relevance 1.01 Pain Relevance 0.21
Schmid et al. [59] demonstrated that sleep restriction led to a reduction in physical activity under free-living conditions, but there were no significant changes in food intake, hunger and appetite, and levels of leptin and ghrelin.
Neg (no) Regulation (changes) of leptin
6) Confidence 0.53 Published 2010 Journal Journal of Obesity Section Body Doc Link PMC2925323 Disease Relevance 0.12 Pain Relevance 0
Alterations in hormones such as leptin, cortisol, and TSH and GH observed with sleep restriction could therefore be the result of disrupted SCN output.
Regulation (Alterations) of leptin
7) Confidence 0.53 Published 2010 Journal Journal of Obesity Section Body Doc Link PMC2925323 Disease Relevance 0.43 Pain Relevance 0
Centrifugal modulation of human LEP components to a task-relevant noxious stimulation triggering voluntary movement.
Regulation (modulation) of LEP associated with pain
8) Confidence 0.52 Published 2009 Journal Neuroimage Section Title Doc Link 19101637 Disease Relevance 0 Pain Relevance 0.34
In another study, Creutzberg et al. [83] documented impairments of normal leptin feedback mechanisms during exacerbations of COPD suggesting that elevated leptin concentrations might represent an up-regulation of leptin mRNA in adipose tissue resulting in an enhanced leptin production in such patients.
Regulation (regulation) of leptin in adipose tissue associated with pulmonary disease and obesity
9) Confidence 0.52 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 1.35 Pain Relevance 0.17
In phase I, mean leptin levels did not change over the week before surgery, had a maximal decrease to 49% of baseline 2 h after surgery, and increased to just above baseline 24 h postoperatively.
Neg (not) Regulation (change) of leptin
10) Confidence 0.45 Published 1999 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 10404818 Disease Relevance 0.45 Pain Relevance 0.19
In summary, taking all these observations into account our findings suggest that the increased leptin levels described so far in patients with OSA is mostly associated with obesity and not with the disease itself or its severity; accordingly short and long term treatment with CPAP has a small effect on leptin plasma levels and Auto-CPAP therapy compliance is not related with the leptin values decrease.
Regulation (effect) of leptin in plasma associated with apnoea, obesity and disease
11) Confidence 0.45 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2567288 Disease Relevance 0.44 Pain Relevance 0
On the contrary, other hypothalamic and extrahypothalamic sites appear to continue relatively sensitive to the actions of leptin, including the ventromedial hypothalamic nuclei, which has been previously shown to mediate leptin-induced sympathetic nerve activation (Satoh et al 1999).
Regulation (sensitive) of leptin in nerve
12) Confidence 0.45 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993994 Disease Relevance 0.50 Pain Relevance 0.04
Our objective was to test the feasibility of the 980-nm diode laser for LEP (laser evoked potentials) studies.
Regulation (feasibility) of LEP
13) Confidence 0.44 Published 2001 Journal Lasers Surg Med Section Abstract Doc Link 11295759 Disease Relevance 0.09 Pain Relevance 0.09
LeptiCore's ability to lower CRP levels allows the remaining circulating leptin to reside in its "free" state and bind to appetite-regulating leptin receptors in the hypothalamus.
Regulation (regulating) of leptin in hypothalamus
14) Confidence 0.43 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2836327 Disease Relevance 0.86 Pain Relevance 0.13
Cortisol may influence the reward value of food via neuroendocrine/peptide mediators such as leptin, insulin and neuropeptide Y (NPY).
Spec (may) Regulation (influence) of leptin associated with neuropeptide
15) Confidence 0.43 Published 2007 Journal Physiol. Behav. Section Abstract Doc Link 17543357 Disease Relevance 1.21 Pain Relevance 0.25
The expression of TIMP-2 in chondrocytes from normal or overweight patients was highly up-regulated upon treatment with 100 ng/ml of leptin, as a more than five-fold increase over the control value was achieved with this concentration of adipokine.
Regulation (regulated) of leptin in chondrocytes associated with overweight
16) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.78 Pain Relevance 0.07
To our knowledge, the present study is the first trial to compare the effects of prophylactic drugs, cytokine levels, and leptin levels in children with migraine.
Regulation (effects) of leptin associated with migraine and cytokine
17) Confidence 0.41 Published 2009 Journal Pediatr. Neurol. Section Abstract Doc Link 19748048 Disease Relevance 0.59 Pain Relevance 0.84
CONCLUSIONS: Hypoestrogenism induced by GnRH analogues (GnRHa) does not seem to influence leptin levels in normal women and those with PMS, and the addition of tibolone does not impact on these levels.
Regulation (influence) of leptin
18) Confidence 0.41 Published 2003 Journal Clin. Endocrinol. (Oxf) Section Body Doc Link 14974912 Disease Relevance 0.05 Pain Relevance 0
This review illustrates the broad front of current research regarding the effects of bioactive agents on biliary motility, including enteric hormones, nitric oxide, opioids, inflammatory mediators, leptin, protease inhibitors, neurotransmitters, and electroacupuncture.
Regulation (effects) of leptin associated with neurotransmitter, inflammatory mediators, electroacupuncture and opioid
19) Confidence 0.38 Published 2003 Journal Curr Gastroenterol Rep Section Abstract Doc Link 12631457 Disease Relevance 0.43 Pain Relevance 0.30
Moreover, these results suggest that changes in serum leptin and insulin concentrations are independent on the etiology of chronic pancreatitis.


Regulation (changes) of serum leptin
20) Confidence 0.37 Published 2008 Journal Pancreas Section Body Doc Link 18376301 Disease Relevance 0 Pain Relevance 0

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