INT75918

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Context Info
Confidence 0.23
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 19
Total Number 20
Disease Relevance 10.05
Pain Relevance 14.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cpox) oxidoreductase activity (Cpox) cytoplasm (Cpox)
Anatomy Link Frequency
granulation 2
stomach 2
bowel 2
Cpox (Rattus norvegicus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 44 100.00 Very High Very High Very High
Analgesic 19 100.00 Very High Very High Very High
acular 13 100.00 Very High Very High Very High
cOX1 12 100.00 Very High Very High Very High
COX2 9 100.00 Very High Very High Very High
cytokine 5 100.00 Very High Very High Very High
Paracetamol 4 100.00 Very High Very High Very High
aspirin 13 99.98 Very High Very High Very High
IPN 6 99.96 Very High Very High Very High
cINOD 46 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Colon Cancer 8 100.00 Very High Very High Very High
Cancer 5 100.00 Very High Very High Very High
Necrosis 3 100.00 Very High Very High Very High
Peptic Ulcer 1 100.00 Very High Very High Very High
Inflammatory Pain 6 99.96 Very High Very High Very High
Ulcers 1 99.92 Very High Very High Very High
Injury 6 99.22 Very High Very High Very High
Intestinal Cancer 1 98.94 Very High Very High Very High
INFLAMMATION 49 98.56 Very High Very High Very High
Sprains And Strains 1 98.22 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The absence of detectable effects of caffeine on time course or magnitude of ketoprofen-induced suppression of PGE(2) biosynthesis in this model indicates, therefore, that possible adverse actions of co-administered caffeine on renal function are not related to interference with renal COX inhibition.
Negative_regulation (interference) of Negative_regulation (inhibition) of COX
1) Confidence 0.23 Published 2001 Journal Pharmacology Section Abstract Doc Link 11729362 Disease Relevance 0 Pain Relevance 0.15
IMPLICATIONS: Our data suggest that a COX-2 selective inhibitor, but not a COX-1 selective inhibitor, may produce a good analgesic effect on the inflammatory pain state in a clinical situation.
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of COX associated with ipn and analgesic
2) Confidence 0.21 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 11916805 Disease Relevance 0.31 Pain Relevance 0.38
Other rats received intrathecally the COX-1 preferring inhibitor, ketorolac, the specific COX-1 inhibitor, SC-560, the COX-2 inhibitor, NS-398 or vehicle 1 day after surgery.
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of COX associated with acular and cox-2 inhibitor
3) Confidence 0.20 Published 2003 Journal Pain Section Abstract Doc Link 12855310 Disease Relevance 0.36 Pain Relevance 1.01
Other rats received intrathecally the COX-1 preferring inhibitor, ketorolac, the specific COX-1 inhibitor, SC-560, the COX-2 inhibitor, NS-398 or vehicle 1 day after surgery.
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of COX associated with acular and cox-2 inhibitor
4) Confidence 0.20 Published 2003 Journal Pain Section Abstract Doc Link 12855310 Disease Relevance 0.36 Pain Relevance 1.02
Other rats received intrathecally the COX-1 preferring inhibitor, ketorolac, the specific COX-1 inhibitor, SC-560, the COX-2 inhibitor, NS-398 or vehicle 1 day after surgery.
Negative_regulation (received) of Negative_regulation (inhibitor) of COX associated with acular and cox-2 inhibitor
5) Confidence 0.20 Published 2003 Journal Pain Section Abstract Doc Link 12855310 Disease Relevance 0.36 Pain Relevance 1.03
Other rats received intrathecally the COX-1 preferring inhibitor, ketorolac, the specific COX-1 inhibitor, SC-560, the COX-2 inhibitor, NS-398 or vehicle 1 day after surgery.
Negative_regulation (received) of Negative_regulation (inhibitor) of COX associated with acular and cox-2 inhibitor
6) Confidence 0.20 Published 2003 Journal Pain Section Abstract Doc Link 12855310 Disease Relevance 0.36 Pain Relevance 1.01
Other rats received intrathecally the COX-1 preferring inhibitor, ketorolac, the specific COX-1 inhibitor, SC-560, the COX-2 inhibitor, NS-398 or vehicle 1 day after surgery.
Negative_regulation (received) of Negative_regulation (inhibitor) of COX associated with acular and cox-2 inhibitor
7) Confidence 0.20 Published 2003 Journal Pain Section Abstract Doc Link 12855310 Disease Relevance 0.30 Pain Relevance 0.95
These results indicate that inhibition of central COX pathways, presumably via COX-2 inhibition, reduces inflammatory pain by enhancing the cannabinoid-induced antinociceptive effect.
Negative_regulation (reduces) of Negative_regulation (inhibition) of COX associated with cannabinoid, ipn and antinociceptive
8) Confidence 0.17 Published 2007 Journal Pain Section Abstract Doc Link 17321048 Disease Relevance 0.60 Pain Relevance 1.14
A 10 microg dose of WIN 55,212-2 that was ineffective in producing antinociception became effective following intracisternal administration of NS-398, a selective COX-2 inhibitor; indomethacin, a non-selective COX 1/2 inhibitor; acetaminophen, a putative COX-3 inhibitor, but not following pretreatment with the selective COX-1 inhibitor, SC-560.
Negative_regulation (inhibitor) of Negative_regulation (inhibitor) of COX associated with antinociception, paracetamol, cox-2 inhibitor and cox1
9) Confidence 0.17 Published 2007 Journal Pain Section Abstract Doc Link 17321048 Disease Relevance 0.85 Pain Relevance 1.22
We examined whether inhibition of the proinflammatory cytokines, tumor necrosis factor alpha (TNFalpha) and interleukin-1 (IL-1), or selective blockade of cyclooxygenase-2 (COX-2), the COX isoform induced during inflammation, would accelerate postoperative small bowel transit in our model.
Spec (whether) Negative_regulation (inhibition) of Spec (whether) Negative_regulation (blockade) of COX in bowel associated with necrosis, inflammation, cancer and cytokine
10) Confidence 0.16 Published 1999 Journal J. Surg. Res. Section Abstract Doc Link 10452868 Disease Relevance 0.56 Pain Relevance 0.35
Aspirin decreases the risk of colorectal cancer, reportedly through suppression of cyclooxygenase (COX) activity.
Negative_regulation (decreases) of Negative_regulation (suppression) of COX associated with aspirin and colon cancer
11) Confidence 0.16 Published 1998 Journal Life Sci. Section Abstract Doc Link 9627095 Disease Relevance 0.33 Pain Relevance 0.19
Pre-treatment with naltrexone diminished the analgesic effects of a COX-2 inhibitor, and its antinociception was abolished in rats made tolerant to the analgesic effects of morphine [4].
Negative_regulation (diminished) of Negative_regulation (inhibitor) of COX associated with antinociception, analgesic, cox-2 inhibitor and morphine
12) Confidence 0.14 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC3000619 Disease Relevance 0.51 Pain Relevance 1.97
COX-2 inhibitors delay the healing of chronic gastric ulcers in experimental animals and decrease epithelial cell proliferation, angiogenesis and maturation of the granulation tissue to the same extent as non-steroidal anti-inflammatory drugs.
Negative_regulation (decrease) of Negative_regulation (inhibitors) of COX in granulation associated with inflammation, cinod, cox-2 inhibitor and peptic ulcer
13) Confidence 0.12 Published 2001 Journal Life Sci. Section Abstract Doc Link 11758826 Disease Relevance 0.61 Pain Relevance 0.47
However, other COX-2 preferential inhibitors such as meloxicam and etodolac did not exhibit any apparent action, and also, preferential COX-1 inhibitors mofezolac and indomethacin, COX-1 and COX-2 inhibitor loxoprofen sodium showed a weak effect.
Negative_regulation (inhibitors) of Negative_regulation (inhibitor) of COX associated with cox-2 inhibitor
14) Confidence 0.06 Published 2006 Journal Neurosci. Res. Section Abstract Doc Link 16473424 Disease Relevance 0.46 Pain Relevance 0.65
Cyclooxygenase inhibition, particularly COX 2 inhibition, is one putative biochemical target of the chemopreventive activity of NSAIDs.
Negative_regulation (inhibition) of Negative_regulation (inhibition) of COX associated with cinod and cox2
15) Confidence 0.06 Published 1998 Journal Eur J Surg Suppl Section Abstract Doc Link 10029375 Disease Relevance 1.09 Pain Relevance 0.82
Using two animal models of aging, the senescence accelerated prone 8 mouse strain (SAMP8) and ovariectomized rats, we recently reported that EGb761 treatment effectively prevented the decrease of cytochrome c oxidase (COX) activity, mitochondrial ATP content and mitochondrial GSH content in hippocampi of aged SAMP8 mice and ovariectomized rats [47,48].
Negative_regulation (prevented) of Negative_regulation (decrease) of COX associated with aging and sprains and strains
16) Confidence 0.04 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820992 Disease Relevance 0.95 Pain Relevance 0
The underlying mechanisms of gastric injury include topical irritant actions that disrupt the epithelial barrier, as well as the inhibition of cyclo-oxygenase (COX), which is predominantly the COX-1 isoform in the mucosa.
Negative_regulation (disrupt) of Negative_regulation (inhibition) of COX associated with injury
17) Confidence 0.02 Published 2003 Journal Fundam Clin Pharmacol Section Abstract Doc Link 12803569 Disease Relevance 0.40 Pain Relevance 0.40
They result in these complications mainly by reducing cytoprotective prostaglandins (PGE2 and PGI2) in the stomach, through the inhibition of cyclo-oxygenase (COX) enzyme.
Negative_regulation (reducing) of Negative_regulation (inhibition) of COX in stomach
18) Confidence 0.02 Published 1999 Journal Ir J Med Sci Section Abstract Doc Link 10624361 Disease Relevance 0.49 Pain Relevance 0.85
A majority of animal studies provide strong evidence that prevention of intestinal tumors is more efficiently accomplished by COX-2 selective inhibition rather than by COX-1 suppression.
Negative_regulation (inhibition) of Negative_regulation (suppression) of COX associated with intestinal cancer
19) Confidence 0.01 Published 2003 Journal Semin. Oncol. Section Abstract Doc Link 12802790 Disease Relevance 0.70 Pain Relevance 0.23
NSAIDs act by reducing prostaglandin biosynthesis through inhibition of cyclooxygenase (COX) which exists as two isoforms (COX-1 and COX-2).
Negative_regulation (reducing) of Negative_regulation (inhibition) of COX associated with cinod
20) Confidence 0.01 Published 2001 Journal Am. J. Nephrol. Section Abstract Doc Link 11275626 Disease Relevance 0.45 Pain Relevance 0.55

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