INT75919

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Context Info
Confidence 0.63
First Reported 1998
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 23
Total Number 34
Disease Relevance 16.44
Pain Relevance 9.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Slc8a1) plasma membrane (Slc8a1) transmembrane transport (Slc8a1)
response to stress (Slc8a1)
Anatomy Link Frequency
nerve 5
cardiomyocytes 3
neurons 3
heart 2
smooth muscle 1
Slc8a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 575 99.56 Very High Very High Very High
nMDA receptor 330 99.32 Very High Very High Very High
sodium channel 672 99.20 Very High Very High Very High
aspirin 12 98.86 Very High Very High Very High
Action potential 157 98.76 Very High Very High Very High
dorsal root ganglion 432 98.68 Very High Very High Very High
nociceptor 61 97.56 Very High Very High Very High
Pain 19 96.56 Very High Very High Very High
Glutamate 186 93.84 High High
Analgesic 3 93.44 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 305 99.84 Very High Very High Very High
Aberrant Crypt Foci 3 99.70 Very High Very High Very High
Brain Hemorrhage 380 99.56 Very High Very High Very High
Ganglion Cysts 454 98.68 Very High Very High Very High
Hypoxia 354 98.68 Very High Very High Very High
Injury 198 97.00 Very High Very High Very High
Pain 22 96.56 Very High Very High Very High
Death 76 96.16 Very High Very High Very High
Cv Unclassified Under Development 175 94.80 High High
Nociception 97 94.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Na+/Ca2+ exchanger 1 (NCX1) is a transmembrane protein that is not only expressed in the brain and heart but has also been found in many other tissues and cells, including kidney, skeletal muscle, smooth muscle, lung, and spleen (Quednau et al., 1997).
Gene_expression (expressed) of NCX1 in lung
1) Confidence 0.63 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.57 Pain Relevance 0.38
In the present study, we demonstrated a reduction of Na+/K+ ATPase and increased expression of NCX1 and NR2B in the penumbra by focal cerebral ischemia.
Gene_expression (expression) of NCX1 associated with brain hemorrhage and ischemia
2) Confidence 0.63 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.33 Pain Relevance 0.47
The present study therefore aimed at examining whether the protein expression of Na+/K+-ATPase, NCX1, and functional NMDA receptor subunits (NR2A and NR2B) in the ischemic penumbra were altered.
Spec (whether) Gene_expression (expression) of NCX1 associated with nmda receptor
3) Confidence 0.63 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.38 Pain Relevance 0.50
The changes in protein expression of Na+/K+-ATPase and NCX1 as well as functional subunits of NMDA receptor 2A and 2B (NR2A and NR2B) in the penumbra were assessed using by quantitative immunoblottings.
Gene_expression (expression) of NCX1 associated with nmda receptor
4) Confidence 0.49 Published 2010 Journal Anatomy & Cell Biology Section Abstract Doc Link PMC3015038 Disease Relevance 0.32 Pain Relevance 0.33
Altered expression of Na+/K+-ATPase and NCX1 in the penumbra after focal cerebral ischemia
Gene_expression (expression) of NCX1 associated with brain hemorrhage and ischemia
5) Confidence 0.49 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 1.12 Pain Relevance 0.43
The present study revealed that 1) the altered expression of Na+/K+-ATPase and NCX1 in the penumbra after focal cerebral ischemia indicates that deranged transport of Na+, K+, and Ca2+ which is closely associated with the NMDA receptor-mediated Ca2+ influx ; 2) the different expression of NR2A-containing- and NR2B-containing glutamate-dependent NMDA receptors in the penumbra may play different roles depending on the duration of ischemia; 3) prominent decrease of NeuN than that of GFAP in the penumbra may suggest that neurons in the penumbra are likely to be more susceptible to ischemic injury than astroglia.
Spec (may) Gene_expression (expression) of NCX1 in neurons associated with brain hemorrhage, glutamate, nmda receptor, ischemia and injury
6) Confidence 0.49 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.73 Pain Relevance 0.46
As shown in Fig. 5, hypoxia-reoxygenated cardiomyocytes pretreated with 50 µM thiopental showed higher levels of SERCA2a (p < 0.05), but the expression of NCX protein decreased (p < 0.05).
Gene_expression (expression) of NCX protein in cardiomyocytes associated with hypoxia
7) Confidence 0.35 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.54 Pain Relevance 0
Figure 4 shows Western blots of SERCA2a and NCX protein expression.
Gene_expression (expression) of NCX
8) Confidence 0.33 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.74 Pain Relevance 0
Treatment of hypoxia-reoxygenated cells with 50 µM thiopental resulted in up-regulation of mRNA transcription levels of SERCA2a and PMCA1 (p < 0.05), and decreased NCX gene expression (p < 0.01).
Gene_expression (expression) of NCX gene associated with hypoxia
9) Confidence 0.31 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.56 Pain Relevance 0
However, mRNA levels of Na+-Ca2+ exchanger (NCX) and calsequestrin increased in hypoxia-reoxygenated cardiomyocytes.
Gene_expression (exchanger) of NCX in cardiomyocytes associated with hypoxia
10) Confidence 0.30 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.70 Pain Relevance 0
It has been reported that PMCAs play a major role in maintaining a basal level of Ca2+ in brain39 and NCX is essential for maintaining Ca2+ homeostasis in cardiomyocytes.41 Our results indicate that attenuation of abnormal NCX gene expression by thiopental (p < 0.01) may be an important target for cardioprotection.
Gene_expression (expression) of NCX gene in cardiomyocytes
11) Confidence 0.27 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.52 Pain Relevance 0
Reduced expression of SERCA2a and increased expression of NCX are core changes that contribute to altered Ca2+ homeostasis in the failing heart.37 Reduced expression of SERCA2a and modest, but significantly, increased expression of NCX (reverse mode) in our results would contribute to intracellular Ca2+ overload following hypoxia-reoxygenation.
Gene_expression (expression) of NCX in heart associated with hypoxia
12) Confidence 0.27 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.42 Pain Relevance 0
The rate of decline of the Ca2+ transient is dominated by the rate of Ca2+ uptake by the SR and, to a lesser extent, sarcolemmal Ca2+ extrusion by the Na+/Ca2+ exchanger (NCX), which contributes ?
Gene_expression (exchanger) of NCX
13) Confidence 0.25 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.74 Pain Relevance 0
However, Ca2+ extrusion via NCX during the decline of the Ca2+ transient will lead to Na+ entry, which, during the diastolic period, will increase resting [Ca2+]i and help restore SR Ca2+ levels.
Gene_expression (extrusion) of NCX
14) Confidence 0.25 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.49 Pain Relevance 0.07
SA nodal cell action potential generation is promoted by spontaneous SR Ca2+ release, which produces inward current by NCX (Maltsev et al. [33]).
Gene_expression (produces) of NCX associated with action potential
15) Confidence 0.25 Published 2008 Journal Diabetes Section Body Doc Link PMC2494698 Disease Relevance 0.92 Pain Relevance 0.05
Reduced expression of SERCA2a and increased expression of NCX are core changes that contribute to altered Ca2+ homeostasis in the failing heart.37 Reduced expression of SERCA2a and modest, but significantly, increased expression of NCX (reverse mode) in our results would contribute to intracellular Ca2+ overload following hypoxia-reoxygenation.
Gene_expression (expression) of NCX in heart associated with hypoxia
16) Confidence 0.24 Published 2010 Journal Yonsei Medical Journal Section Body Doc Link PMC2824862 Disease Relevance 0.40 Pain Relevance 0
The Na+/Ca2+ exchanger 1 (NCX1) is a transmembrane protein that is not only expressed in the brain and heart but has also been found in many other tissues and cells, including kidney, skeletal muscle, smooth muscle, lung, and spleen (Quednau et al., 1997).
Gene_expression (expressed) of NCX1 in smooth muscle
17) Confidence 0.21 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.57 Pain Relevance 0.38
The Na+/Ca2+ exchanger 1 (NCX1) is a transmembrane protein that is not only expressed in the brain and heart but has also been found in many other tissues and cells, including kidney, skeletal muscle, smooth muscle, lung, and spleen (Quednau et al., 1997).
Gene_expression (expressed) of NCX1 in kidney
18) Confidence 0.21 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.57 Pain Relevance 0.38
The Na+/Ca2+ exchanger 1 (NCX1) is a transmembrane protein that is not only expressed in the brain and heart but has also been found in many other tissues and cells, including kidney, skeletal muscle, smooth muscle, lung, and spleen (Quednau et al., 1997).
Gene_expression (expressed) of NCX1 in spleen
19) Confidence 0.21 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.57 Pain Relevance 0.38
The Na+/Ca2+ exchanger 1 (NCX1) is a transmembrane protein that is not only expressed in the brain and heart but has also been found in many other tissues and cells, including kidney, skeletal muscle, smooth muscle, lung, and spleen (Quednau et al., 1997).
Gene_expression (expressed) of NCX1 in skeletal muscle
20) Confidence 0.21 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC3015038 Disease Relevance 0.57 Pain Relevance 0.38

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