INT75921

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Context Info
Confidence 0.59
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 8.58
Pain Relevance 8.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ngfr) signal transduction (Ngfr) nuclear envelope (Ngfr)
Golgi apparatus (Ngfr) plasma membrane (Ngfr) nucleus (Ngfr)
Anatomy Link Frequency
joint 4
sciatic nerve 4
neurons 3
theca cells 1
neural 1
Ngfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 128 100.00 Very High Very High Very High
Central nervous system 46 99.70 Very High Very High Very High
bDMF 639 99.60 Very High Very High Very High
Pain 20 99.12 Very High Very High Very High
Sciatic nerve 208 98.96 Very High Very High Very High
algogenic 5 97.92 Very High Very High Very High
Paresthesia 4 97.88 Very High Very High Very High
Potency 1 97.12 Very High Very High Very High
headache 4 95.24 Very High Very High Very High
nociceptor 2 94.60 High High
Disease Link Frequency Relevance Heat
Arthralgia 4 99.36 Very High Very High Very High
Nervous System Injury 29 98.64 Very High Very High Very High
Dysesthesia 4 97.88 Very High Very High Very High
Cancer 2 97.52 Very High Very High Very High
Necrosis 2 97.28 Very High Very High Very High
Ganglion Cysts 8 97.16 Very High Very High Very High
Common Cold 4 96.92 Very High Very High Very High
Diabetes Mellitus 18 96.76 Very High Very High Very High
Headache 4 95.24 Very High Very High Very High
Polycystic Ovary Syndrome 87 93.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: p75NTR inhibition may be a therapeutic target for inflamed joint pain treatment with reduced adverse events.


Negative_regulation (inhibition) of p75NTR in joint
1) Confidence 0.59 Published 2010 Journal J Hand Surg Am Section Body Doc Link 20060234 Disease Relevance 0.05 Pain Relevance 0
We hypothesized that inhibition of the low-affinity NGF receptor, p75 neurotrophin receptor (p75NTR), is also effective for joint pain and may reduce side effects.
Negative_regulation (inhibition) of p75NTR in joint associated with pain, arthralgia and nerve growth factor
2) Confidence 0.43 Published 2010 Journal J Hand Surg Am Section Abstract Doc Link 20060234 Disease Relevance 1.08 Pain Relevance 1.23
We hypothesized that inhibition of the low-affinity NGF receptor, p75 neurotrophin receptor (p75NTR), is also effective for joint pain and may reduce side effects.
Negative_regulation (inhibition) of NGF receptor in joint associated with pain, arthralgia and nerve growth factor
3) Confidence 0.43 Published 2010 Journal J Hand Surg Am Section Abstract Doc Link 20060234 Disease Relevance 1.08 Pain Relevance 1.22
We hypothesized that inhibition of the low-affinity NGF receptor, p75 neurotrophin receptor (p75NTR), is also effective for joint pain and may reduce side effects.
Negative_regulation (inhibition) of p75 neurotrophin receptor in joint associated with pain, arthralgia and nerve growth factor
4) Confidence 0.43 Published 2010 Journal J Hand Surg Am Section Abstract Doc Link 20060234 Disease Relevance 1.08 Pain Relevance 1.23
Furthermore, intraovarian blockade of NGF and p75NTR resulted in decreased p75NTR synthesis by ovarian theca cells and restored estrous cyclicity and ovulatory capacity in EV-injected rats [10].
Negative_regulation (blockade) of p75NTR in theca cells associated with nerve growth factor
5) Confidence 0.38 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1175857 Disease Relevance 0.40 Pain Relevance 0.36
Osmopump delivery prevented the decline of NGFR-TrkA, insulin receptor (P < 0.05), and IGF-IR (P < 0.005) expressions in DRGs and improved NGF content (P < 0.05) in sciatic nerve.
Negative_regulation (decline) of NGFR-TrkA in sciatic nerve associated with nerve growth factor and sciatic nerve
6) Confidence 0.33 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.35 Pain Relevance 0.46
Osmopump delivery prevented the decline of NGFR-TrkA, insulin receptor (P < 0.05), and IGF-IR (P < 0.005) expressions in DRGs and improved NGF content (P < 0.05) in sciatic nerve.
Negative_regulation (decline) of NGFR-TrkA in sciatic nerve associated with nerve growth factor and sciatic nerve
7) Confidence 0.33 Published 2006 Journal Diabetes Section Abstract Doc Link 17130507 Disease Relevance 1.35 Pain Relevance 0.46
Most of the studies performed have considered the loss of ChAT, acetyl cholinesterase (AChE) or p75 neurotrophin receptor (p75) immunoreactivity as an analogue of neurodegeneration [19-22], ruling out the possibility that neurons lose their cholinergic phenotype without dying.
Negative_regulation (loss) of p75 in neurons
8) Confidence 0.31 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2826326 Disease Relevance 0.22 Pain Relevance 0.47
Most of the studies performed have considered the loss of ChAT, acetyl cholinesterase (AChE) or p75 neurotrophin receptor (p75) immunoreactivity as an analogue of neurodegeneration [19-22], ruling out the possibility that neurons lose their cholinergic phenotype without dying.
Negative_regulation (loss) of p75 in neurons
9) Confidence 0.31 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2826326 Disease Relevance 0.17 Pain Relevance 0.47
BDNF is upregulated and p75NTR is down-regulated in sensory neurons after sciatic nerve injury [12], [35].
Negative_regulation (down) of p75NTR in sciatic nerve associated with nervous system injury, sciatic nerve and bdmf
10) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.43 Pain Relevance 0.66
BDNF is upregulated and p75NTR is down-regulated in sensory neurons after sciatic nerve injury [12], [35].
Negative_regulation (regulated) of p75NTR in sciatic nerve associated with nervous system injury, sciatic nerve and bdmf
11) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.43 Pain Relevance 0.67
Our previous studies showed that sciatic nerve transection significantly increased p75NTR in glia but decreased p75NTR in neurons in the DRG [35]. p75NTR expression in glial cells may have a role in nerve regeneration opposing that in neurons [68], [69].
Negative_regulation (decreased) of p75NTR in neurons associated with sciatic nerve
12) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2246162 Disease Relevance 0.37 Pain Relevance 0.37
bFGF: basic fibroblast growth factor; CA: constitutive active form; CNS: central nervous system; DN: dominant negative form; GFP: green fluorescent protein; JNK: c-jun N-terminal kinase; NSPC: neural stem/progenitor cell; p75NTR: p75 neurotrophin receptor; ssDNA: single stranded DNA; TNF: tumor necrosis factor.


Negative_regulation (negative) of p75NTR in neural associated with necrosis, cancer and central nervous system
13) Confidence 0.16 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.31 Pain Relevance 0.21
However, phosphate buffered SIF at pH 6.1 and 6.4 caused a substantial and significant decrease of the PGE2 release, probably due to low-pH block of phospholipases.
Negative_regulation (block) of low-pH
14) Confidence 0.10 Published 1998 Journal Life Sci. Section Abstract Doc Link 9627103 Disease Relevance 0.23 Pain Relevance 0.56

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