INT75923

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Context Info
Confidence 0.45
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.49
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6ST) extracellular region (IL6ST) plasma membrane (IL6ST)
Anatomy Link Frequency
endometrium 1
kidney 1
blood cell 1
IL6ST (Homo sapiens)
Pain Link Frequency Relevance Heat
Fibrositis 13 99.96 Very High Very High Very High
Inflammation 6 99.32 Very High Very High Very High
cytokine 12 98.86 Very High Very High Very High
Pain 11 95.96 Very High Very High Very High
pressure hyperalgesia 1 93.28 High High
Inflammatory response 5 85.76 High High
antagonist 2 80.68 Quite High
anesthesia 1 79.72 Quite High
Pain scale 1 71.88 Quite High
depression 1 70.20 Quite High
Disease Link Frequency Relevance Heat
Fibromyalgia 11 99.96 Very High Very High Very High
Influenza Virus Infection 9 99.62 Very High Very High Very High
INFLAMMATION 10 99.32 Very High Very High Very High
Musculoskeletal Disease 1 95.64 Very High Very High Very High
Hyperalgesia 1 92.92 High High
Depression 3 90.32 High High
Leukemia 2 85.16 High High
Malaria 27 83.84 Quite High
Hematological Disease 3 80.32 Quite High
Gallstones 1 77.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The immune-inflammatory pathophysiology of fibromyalgia: increased serum soluble gp130, the common signal transducer protein of various neurotrophic cytokines.
Positive_regulation (increased) of gp130 associated with inflammation, fibrositis and cytokine
1) Confidence 0.45 Published 1999 Journal Psychoneuroendocrinology Section Title Doc Link 10341365 Disease Relevance 1.30 Pain Relevance 1.02
Inactivation of IL6ST, a component of the functional receptors for LIF and OSM, leads to developmental defects in the kidney [53,54].
Positive_regulation (Inactivation) of IL6ST in kidney
2) Confidence 0.38 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.09 Pain Relevance 0
This was in agreement with the immunohistochemical observations of Classen-Linke et al. (2004) who also showed an increase in GP130 staining during early-mid and late secretory endometrium.


Positive_regulation (increase) of GP130 in endometrium
3) Confidence 0.29 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
The haemagglutinin of the influenza virus is a fusion-inducing membrane glycoprotein, which facilitates antigen delivery to immunocompetent cells.
Positive_regulation (inducing) of membrane glycoprotein associated with influenza virus infection
4) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2001290 Disease Relevance 0.67 Pain Relevance 0
The changes in blood cell populations were accompanied by an increase in IL-6 on days 1, 3, and 7 following surgery, in IL-6sR on days 10 and 14 and in IL-8 on days 1 and 3.
Positive_regulation (increase) of IL-6sR in blood cell
5) Confidence 0.01 Published 1998 Journal Eur Surg Res Section Abstract Doc Link 9627217 Disease Relevance 0.43 Pain Relevance 0.18

General Comments

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