INT75929

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Context Info
Confidence 0.43
First Reported 1998
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 61
Total Number 63
Disease Relevance 24.71
Pain Relevance 16.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL9) extracellular region (IL9)
Anatomy Link Frequency
T cells 17
microglial cells 4
mast cells 3
goblet cells 2
iTreg 2
IL9 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1313 100.00 Very High Very High Very High
Inflammation 939 99.98 Very High Very High Very High
dorsal root ganglion 8 99.92 Very High Very High Very High
Spinal cord 6 99.68 Very High Very High Very High
Cannabinoid 30 99.54 Very High Very High Very High
Analgesic 5 99.30 Very High Very High Very High
antagonist 153 99.04 Very High Very High Very High
pulpitis 2 98.84 Very High Very High Very High
Neuritis 45 97.52 Very High Very High Very High
Cannabinoid receptor 5 97.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 989 99.98 Very High Very High Very High
Asthma 1292 99.92 Very High Very High Very High
Ganglion Cysts 8 99.92 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 18 99.66 Very High Very High Very High
Sepsis 39 99.58 Very High Very High Very High
Eosinophilia 102 99.52 Very High Very High Very High
Vasculitis 8 99.32 Very High Very High Very High
Pulpitis 2 98.84 Very High Very High Very High
Primary Sclerosing Cholangitis 154 98.80 Very High Very High Very High
Pneumonia 32 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
stimulated resting memory CD4+ T cells demonstrated that the addition of enhances IL-9 production.
Gene_expression (production) of IL-9 in T cells
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.10 Pain Relevance 0.10
in combination induced IL-9 expression in both naïve and memory CD4+ T cells, but higher percentage of memory CD4+ T cells expressed IL-9.
Gene_expression (expression) of IL-9 in T cells
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0.03
induced expression of IL-9 in up to 10% of pbCD3/sCD28 activated CD4+ T cells.
Gene_expression (expression) of IL-9 in T cells
3) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.25 Pain Relevance 0.11
We then examined for IL-9 production by human CD4+CD25?
Spec (examined) Gene_expression (production) of IL-9
4) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0.09
However, if this induction of IL-9 production was dependent or independent of TGF-?
Gene_expression (production) of IL-9
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.35 Pain Relevance 0.14
Our analysis which includes a successful effort to optimize IL-9 expression or frequency of CD4+IL-9+ T cells and their molecular phenotype reveals both similarities and distinctions between human and murine IL-9+ T cells.
Gene_expression (expression) of IL-9 in T cells
6) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.07 Pain Relevance 0.03
As IL-9 is expressed by human Th2 cells and mouse “Th9” cells produced IL-10, we hypothesized that TGF-?
Gene_expression (expressed) of IL-9 in Th2 cells
7) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0.11
RII-transfected fibroblasts, induces naïve or memory CD4+ T cells to produce IL-9 [14].
Gene_expression (produce) of IL-9 in T cells
8) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.36 Pain Relevance 0.14
Robust IL-9 expression was detected in IL-4+TGF-?
Gene_expression (expression) of IL-9
9) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0.09
Attempts to optimize IL-9 production by pbCD3/sCD28 and IL-4+TGF-?
Gene_expression (production) of IL-9
10) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.09 Pain Relevance 0.09
, IL-12, and IL-21, enhance IL-9 production.
Gene_expression (production) of IL-9
11) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.28 Pain Relevance 0.19
-alone induced generation of 2% or 4% of CD4+IL-9+ T cells, whereas no IL-9 was expressed in the absence of IL-4 or TGF-?.
Gene_expression (expressed) of IL-9 in T cells
12) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.26 Pain Relevance 0.11
This data suggests IL-2 is required to maintain viability of IL-9 producers and IL-2 may not directly trigger IL-9 expression.
Gene_expression (expression) of IL-9
13) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.29 Pain Relevance 0.19
T cells to express IL-9.
Gene_expression (express) of IL-9 in T cells
14) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.07 Pain Relevance 0.04
, IL-12, and IL-21 further enhance IL-9 production.


Gene_expression (production) of IL-9
15) Confidence 0.43 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2806834 Disease Relevance 0.15 Pain Relevance 0.12
in combination induced IL-9 expression in both naïve and memory CD4+ T cells, but higher percentage of memory CD4+ T cells expressed IL-9.
Gene_expression (expressed) of IL-9 in T cells
16) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0.06
Our analysis which includes a successful effort to optimize IL-9 expression or frequency of CD4+IL-9+ T cells and their molecular phenotype reveals both similarities and distinctions between human and murine IL-9+ T cells.
Gene_expression (expression) of IL-9 in T cells
17) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.07 Pain Relevance 0.03
IL-9 is produced by mouse and human Th2 cells [15], and by mouse nTregs [13].
Gene_expression (produced) of IL-9 in nTregs
18) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0.06
, induce IL-9 production, and pro-inflammatory cytokines, IL-1?
Gene_expression (production) of IL-9 associated with inflammation and cytokine
19) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.29 Pain Relevance 0.20
In addition, we have determined that resting and memory CD4+ T cells are not equal in their frequency to express IL-9.
Gene_expression (express) of IL-9 in T cells
20) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.06 Pain Relevance 0.03

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