INT75931

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Context Info
Confidence 0.50
First Reported 1998
Last Reported 2000
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.83
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprk1) plasma membrane (Oprk1) signal transducer activity (Oprk1)
Anatomy Link Frequency
bone marrow 2
Oprk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 4 100.00 Very High Very High Very High
Morphine 6 90.28 High High
Opioid 7 89.88 High High
Eae 1 82.28 Quite High
opioid receptor 4 79.68 Quite High
Intracerebroventricular 1 77.28 Quite High
cytokine 4 75.00 Quite High
Dynorphin 1 49.84 Quite Low
Disease Link Frequency Relevance Heat
Lewis Lung Carcinoma 4 94.76 High High
Cancer 7 92.56 High High
Targeted Disruption 1 80.04 Quite High
Apoptosis 1 38.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was shown that this aversive effect might partly be due to kappa-opioid receptor interaction.
Spec (might) Positive_regulation (due) of kappa-opioid receptor Spec (might) Binding (interaction) of associated with kappa opioid receptor
1) Confidence 0.50 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 10882032 Disease Relevance 0.08 Pain Relevance 0.71
Consistently, addition of CSF in the form of lung-conditioned medium (LCM) to adherent bone marrow cells increased the affinity of the kappa-opioid receptor.
Positive_regulation (increased) of kappa-opioid receptor Binding (affinity) of in bone marrow associated with kappa opioid receptor
2) Confidence 0.27 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9629267 Disease Relevance 0.75 Pain Relevance 0.62

General Comments

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