INT75932

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Context Info
Confidence 0.37
First Reported 1998
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 45
Total Number 46
Disease Relevance 33.20
Pain Relevance 8.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf2) extracellular region (Csf2)
Anatomy Link Frequency
macrophage 6
CSF 3
brain 2
hematopoietic stem cell 2
plaque 2
Csf2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 398 100.00 Very High Very High Very High
Intracerebroventricular 13 99.98 Very High Very High Very High
qutenza 9 99.60 Very High Very High Very High
rheumatoid arthritis 466 99.40 Very High Very High Very High
agonist 60 99.40 Very High Very High Very High
Central nervous system 92 98.68 Very High Very High Very High
Multiple sclerosis 128 97.60 Very High Very High Very High
Hippocampus 42 97.52 Very High Very High Very High
metalloproteinase 120 96.60 Very High Very High Very High
methotrexate 100 95.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 821 99.98 Very High Very High Very High
Eosinophilia 25 99.96 Very High Very High Very High
Rhinitis 15 99.96 Very High Very High Very High
Amyloid Plaque 52 99.76 Very High Very High Very High
Cyst 4 99.68 Very High Very High Very High
Lymphatic System Cancer 153 99.58 Very High Very High Very High
Leukocytosis 4 99.44 Very High Very High Very High
Rheumatoid Arthritis 466 99.40 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 102 99.36 Very High Very High Very High
Myeloid Leukemia 27 99.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the RT-PCR assay, the combination of GM-CSF with high doses of LPS increased the expression of mRNA of three cytokines (TNF-?
GM-CSF Binding (combination) of associated with cytokine
1) Confidence 0.37 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526424 Disease Relevance 0.48 Pain Relevance 0.34
B- and T lymphocytes and macrophages were eliminated from bone marrow cells, which were cultured at 37°C for 7 days in 5% FCS-containing RPMI medium complemented with GM-CSF and IL-4 (200 U/ml each), 2 mM glutamine, 1% non-essential amino acids, 50 µM ?
GM-CSF Binding (complemented) of in macrophages
2) Confidence 0.36 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2883599 Disease Relevance 0.06 Pain Relevance 0
However, the hematopoietic action of MIO15 was dependent on the presence of colony-stimulating factors (CSF).
CSF Binding (presence) of
3) Confidence 0.35 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9629267 Disease Relevance 0.68 Pain Relevance 0.73
Aortic dissection associated with cogans's syndrome: deleterious loss of vascular structural integrity is associated with GM-CSF overstimulation in macrophages and smooth muscle cells

Background

GM-CSF Binding (associated) of in macrophages associated with syndrome
4) Confidence 0.32 Published 2010 Journal J Cardiothorac Surg Section Title Doc Link PMC2933604 Disease Relevance 0.82 Pain Relevance 0.13
Binding of GM-CSF activates JAK2, which rapidly induces tyrosine phosphorylation of the ?
GM-CSF Binding (Binding) of
5) Confidence 0.31 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297502 Disease Relevance 0.19 Pain Relevance 0.10
Fluid Biomarkers The sampling of CSF and plasma represents the most direct and convenient means to study the biochemical changes occurring in the central nervous system [10, 19, 41].
CSF Binding (sampling) of in central nervous system associated with central nervous system
6) Confidence 0.29 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2915796 Disease Relevance 0.87 Pain Relevance 0.27
A unique feature of leptomeningeal HL is that it is often associated with a CSF eosinophilic pleocytosis [13, 17, 18].
CSF Binding (associated) of associated with rhinitis, lymphatic system cancer and leukocytosis
7) Confidence 0.27 Published 2011 Journal Advances in Hematology Section Body Doc Link PMC2957132 Disease Relevance 2.55 Pain Relevance 0.16
Other diseases associated with CSF eosinophilia include parasitic diseases (cysticercosis, trichinosis, and helminth infection), tuberculous meningitis, symptomatic neurosyphilis, subacute sclerosing panencephalitis, and Coxsackie virus infection [19].
CSF Binding (associated) of associated with mycobacterial infection, helminth infection, trichuriasis, parasitic infection, neurosyphilis, coxsackie virus infection, subacute sclerosing panencephalitis, cestode infection, disease and eosinophilia
8) Confidence 0.27 Published 2011 Journal Advances in Hematology Section Body Doc Link PMC2957132 Disease Relevance 2.78 Pain Relevance 0.14
No longer does the CSF compartment as assessed by HIV RNA and immune activation markers such as ?
CSF Neg (No) Binding (compartment) of associated with acquired immune deficiency syndrome or hiv infection
9) Confidence 0.26 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1845158 Disease Relevance 0.30 Pain Relevance 0
Previous studies have shown that innate immune dysfunction, associated with absence of interleukin-6 (IL-6), granulocyte-macrophage colony-stimulating factor, IL-1RI, and IL-18, leads to obesity [14]–[19].
granulocyte-macrophage colony-stimulating factor Neg (absence) Binding (absence) of in macrophage associated with obesity
10) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765728 Disease Relevance 1.78 Pain Relevance 0.11
Both GM-CSF and its receptor are absent in normal brain but expressed at high levels in glioma tissues [17].
GM-CSF Binding (receptor) of in brain associated with glioma
11) Confidence 0.20 Published 2008 Journal J Transl Med Section Body Doc Link PMC2645376 Disease Relevance 1.58 Pain Relevance 0.07
A second group fasted for 18 hours prior to the experiment received an ICV injection of CSF, the last group fasted for 18 hours received a single MTII injection.
CSF Binding (injection) of in CSF associated with intracerebroventricular
12) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.39
Furthermore, treatment with GM-CSF fully restored PPAR-?
GM-CSF Binding (treatment) of
13) Confidence 0.12 Published 2007 Journal PPAR Research Section Body Doc Link PMC2066181 Disease Relevance 0.49 Pain Relevance 0.14
B- and T lymphocytes and macrophages were eliminated from bone marrow cells, which were cultured at 37°C for 7 days in 5% FCS-containing RPMI medium complemented with GM-CSF and IL-4 (200 U/ml each), 2 mM glutamine, 1% non-essential amino acids, 50 µM ?
GM-CSF Binding (complemented) of in T lymphocytes
14) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2883599 Disease Relevance 0.06 Pain Relevance 0
in CSF, thereby hindering its aggregation into amyloid plaques [158].
CSF Binding (aggregation) of in plaques associated with amyloid plaque
15) Confidence 0.12 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952897 Disease Relevance 0.80 Pain Relevance 0.05
Thirdly, KA may directly enter the CSF via the nasal cavity, since the CSF has direct connection with the olfactory bulb [97].
CSF Binding (enter) of in olfactory bulb
16) Confidence 0.12 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2992819 Disease Relevance 0.44 Pain Relevance 0.22
Aortic dissection associated with cogans's syndrome: deleterious loss of vascular structural integrity is associated with GM-CSF overstimulation in macrophages and smooth muscle cells

Background

GM-CSF Binding (associated) of in smooth muscle cells associated with syndrome
17) Confidence 0.11 Published 2010 Journal J Cardiothorac Surg Section Title Doc Link PMC2933604 Disease Relevance 0.82 Pain Relevance 0.13
The combination of a negative GM-CSF autoantibody test (29) and an abnormal CD11b stimulation index (24) predicted the GM-CSF receptor dysfunction, which was confirmed by the lack of GM-CSF binding and defective GM-CSF receptor signaling.
GM-CSF Binding (binding) of
18) Confidence 0.11 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.76 Pain Relevance 0
subunit is required for GM-CSF binding and receptor signaling (3).
GM-CSF Binding (binding) of
19) Confidence 0.11 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.45 Pain Relevance 0
Indeed, routine trafficking of T lymphocytes into the CSF and microglia-neuron and microglia-astrocyte interactions are critical for protecting the CNS from invading pathogens, regulating extracellular fluid composition, removing potentially harmful cellular debris, and promoting adaptive neuroplastic responses to CNS challenge.
CSF Binding (interactions) of in microglia associated with central nervous system
20) Confidence 0.11 Published 2011 Journal Parkinson's Disease Section Body Doc Link PMC3018622 Disease Relevance 0.77 Pain Relevance 0.52

General Comments

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