INT75933

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Context Info
Confidence 0.49
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.70
Pain Relevance 1.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf2) extracellular region (Csf2)
Anatomy Link Frequency
osteoclast 2
Csf2 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 3 99.98 Very High Very High Very High
agonist 1 99.78 Very High Very High Very High
cytokine 27 98.00 Very High Very High Very High
Opioid 7 96.00 Very High Very High Very High
Inflammation 20 87.92 High High
Dynorphin 1 87.60 High High
antagonist 2 87.16 High High
Pain 1 75.52 Quite High
opioid receptor 1 75.00 Quite High
Kappa opioid receptor 3 48.00 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 3 98.32 Very High Very High Very High
Osteoporosis 11 98.20 Very High Very High Very High
Hypercalcemia 3 97.14 Very High Very High Very High
INFLAMMATION 17 87.92 High High
Cancer 10 87.92 High High
Pulmonary Alveolar Proteinosis 34 81.36 Quite High
Syndrome 3 78.00 Quite High
Adult Respiratory Distress Syndrome 18 76.16 Quite High
Respiratory Failure 3 75.92 Quite High
Pain 1 75.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the RT-PCR assay, the combination of GM-CSF with high doses of LPS increased the expression of mRNA of three cytokines (TNF-?
Positive_regulation (doses) of GM-CSF Binding (combination) of associated with cytokine
1) Confidence 0.49 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526424 Disease Relevance 0.49 Pain Relevance 0.34
However, the hematopoietic action of MIO15 was dependent on the presence of colony-stimulating factors (CSF).
Positive_regulation (dependent) of CSF Binding (presence) of
2) Confidence 0.46 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9629267 Disease Relevance 0.68 Pain Relevance 0.73
subunit is required for GM-CSF binding and receptor signaling (3).
Positive_regulation (required) of GM-CSF Binding (binding) of
3) Confidence 0.16 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585845 Disease Relevance 0.45 Pain Relevance 0
Capsazepine inhibited osteoclast formation and bone resorption in a dose dependent manner in bone marrow-osteoblast co-cultures and RANKL generated osteoclast cultures, whereas the TRPV1 agonist capsaicin enhanced RANKL and M-CSF stimulated osteoclast formation.
Positive_regulation (enhanced) of M-CSF Binding (formation) of in osteoclast associated with qutenza, agonist, osteoporosis and hypercalcemia
4) Confidence 0.05 Published 2010 Journal Bone Section Abstract Doc Link 20096813 Disease Relevance 1.08 Pain Relevance 0.34

General Comments

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