INT75938

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Context Info
Confidence 0.09
First Reported 1998
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 2.45
Pain Relevance 7.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TP53INP2)
Anatomy Link Frequency
spinal cord 1
T cells 1
TP53INP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 122 100.00 Very High Very High Very High
agonist 66 100.00 Very High Very High Very High
Delta opioid receptors 9 99.96 Very High Very High Very High
Pain 97 99.68 Very High Very High Very High
Ultiva 9 99.36 Very High Very High Very High
Enkephalin 26 98.84 Very High Very High Very High
Perioperative pain 2 97.16 Very High Very High Very High
Immobilon 10 95.92 Very High Very High Very High
Hyperalgesia 11 95.20 Very High Very High Very High
allodynia 10 94.36 High High
Disease Link Frequency Relevance Heat
Pain 129 99.68 Very High Very High Very High
Injury 10 98.60 Very High Very High Very High
Nociception 16 98.04 Very High Very High Very High
Post Operative Pain 2 97.16 Very High Very High Very High
Hyperalgesia 13 95.20 Very High Very High Very High
Neuroblastoma 3 94.84 High High
Neuropathic Pain 24 94.36 High High
Charcot Marie Tooth Disease 2 92.44 High High
Bordatella Infection 5 89.92 High High
Cancer Pain 2 85.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, these results showed complex relationships between hDOR internalization/down-regulation and desensitization.
Regulation (regulation) of hDOR
1) Confidence 0.09 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12672796 Disease Relevance 0 Pain Relevance 0.37
Endogenous human delta-opioid receptors (hDOR) are differentially regulated in terms of desensitization by peptide ([d-Pen2,5]enkephalin (DPDPE) and Deltorphin I) and alkaloid (etorphine) agonists in the neuroblastoma cell line SK-N-BE (Allouche, S., Roussel, M., Marie, N., and Jauzac, P. (1999) Eur.
Regulation (regulated) of hDOR associated with charcot marie tooth disease, neuroblastoma, agonist, enkephalin, delta opioid receptors and immobilon
2) Confidence 0.09 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12672796 Disease Relevance 0.19 Pain Relevance 0.39
As we only obtained a significant DOR effect in the sets including palm view stimuli, one might argue that only the palm view stimuli accounted for the obtained DOR effect in Set-2 and Set-3.
Regulation (effect) of DOR
3) Confidence 0.09 Published 2010 Journal Exp Brain Res Section Body Doc Link PMC2871105 Disease Relevance 0 Pain Relevance 0.03
² = 0.43], which was accounted for by the increasing difference in RTs between laterally and medially rotated stimuli over the stimulus sets, resulting in significant simple DOR effects in Set-2 [F(1,11) = 5.964, P < 0.05, ?
Regulation (effects) of DOR
4) Confidence 0.09 Published 2010 Journal Exp Brain Res Section Body Doc Link PMC2871105 Disease Relevance 0 Pain Relevance 0
The study suggests that down-regulation of DOR contributes to remifentanil and surgery-induced nociception, and that postoperative pain is completely reversed by increasing enkephalin levels in the spinal cord and the periphery.
Regulation (regulation) of DOR in spinal cord associated with nociception, enkephalin, perioperative pain, ultiva and spinal cord
5) Confidence 0.06 Published 2009 Journal Pain Section Abstract Doc Link 19058913 Disease Relevance 1.05 Pain Relevance 1.71
However, DOR efficacy depends on the pain stimulus, the type of injury and the influence of the local neurochemical environment.
Regulation (depends) of DOR associated with pain, injury and opioid receptor
6) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.12 Pain Relevance 2.10
These findings with normal splenic T cells and DOR-transfected T-cell line indicate that beta-EP and DOR agonists affect calcium mobilization.
Regulation (affect) of DOR in T cells associated with agonist and opioid receptor
7) Confidence 0.04 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9629268 Disease Relevance 0.09 Pain Relevance 0.57
In conclusion, hDOR desensitization depends both on its internalization and its sorting either to the recycling pathway or to lysosomes.
Regulation (depends) of hDOR
8) Confidence 0.03 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15102931 Disease Relevance 0 Pain Relevance 0.51
After a 30-min treatment, we observed a different regulation of hDOR between agonists.
Regulation (regulation) of hDOR associated with agonist
9) Confidence 0.02 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15102931 Disease Relevance 0 Pain Relevance 0.88
The signaling studies suggested that (1DMe)NPYF alone did not affect DOR function but when applied together with a DOR agonist it significantly promoted the response of the activated signaling cascade. (1DMe)NPYF could enhance the DOR agonist induced inhibition of forskolin-stimulated cAMP accumulation, a signaling cascade primarily regulated by the Gi/o?
Neg (not) Regulation (affect) of DOR associated with agonist and opioid receptor
10) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079869 Disease Relevance 0 Pain Relevance 0.65

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