INT75955

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Context Info
Confidence 0.77
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 19
Total Number 19
Disease Relevance 4.39
Pain Relevance 10.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd3) plasma membrane (Drd3) signal transducer activity (Drd3)
Anatomy Link Frequency
nucleus accumbens 4
brain 2
striatum 2
forebrain 2
midbrain 1
Drd3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 157 100.00 Very High Very High Very High
antagonist 65 100.00 Very High Very High Very High
Nucleus accumbens 40 99.92 Very High Very High Very High
Thalamus 21 99.68 Very High Very High Very High
fluoxetine 18 99.48 Very High Very High Very High
Endep 24 99.38 Very High Very High Very High
Substantia nigra 11 99.16 Very High Very High Very High
antidepressant 36 98.76 Very High Very High Very High
midbrain 4 98.60 Very High Very High Very High
Desipramine 6 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Shock 10 99.40 Very High Very High Very High
Tremor 348 99.22 Very High Very High Very High
Syndrome 3 95.40 Very High Very High Very High
Dyskinesias 5 95.12 Very High Very High Very High
Toxicity 5 88.40 High High
Alzheimer's Dementia 6 88.20 High High
Watson Syndrome 56 82.36 Quite High
Hypersensitivity 24 77.08 Quite High
Pain 13 71.76 Quite High
Neuropathic Pain 14 71.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under these conditions, no change in dopamine D3 receptor mRNA expression in the limbic forebrain and lower midbrain was observed by prenatal and neonatal exposure to BPA.
Gene_expression (expression) of dopamine D3 receptor mRNA in midbrain associated with dopamine and midbrain
1) Confidence 0.77 Published 2004 Journal Addict Biol Section Abstract Doc Link 15203435 Disease Relevance 0.08 Pain Relevance 0.44
The present data provide further evidence that prenatal and neonatal exposure to BPA leads to the reduction of functional dopamine D3 receptors without affecting the new synthesis of dopamine D3 receptors in the mouse limbic forebrain.
Gene_expression (synthesis) of dopamine D3 in forebrain associated with dopamine
2) Confidence 0.67 Published 2004 Journal Addict Biol Section Abstract Doc Link 15203435 Disease Relevance 0.06 Pain Relevance 0.42
DRD3 receptor is expressed in the thalamus and substantia nigra where limb-movement related neurons are present [42].
Gene_expression (expressed) of DRD3 in substantia nigra associated with substantia nigra and thalamus
3) Confidence 0.62 Published 2008 Journal J Transl Med Section Body Doc Link PMC2613385 Disease Relevance 0.82 Pain Relevance 0.10
The DRD3 receptor expression has been localized to limbic areas of the brain, where it acts via the Go subunit and adenylate cyclase to decrease cAMP levels [20,21].
Gene_expression (expression) of DRD3 receptor in brain
4) Confidence 0.60 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.37 Pain Relevance 0.23
Gene expression analysis shows a 2.7 fold increase in the expression of dopamine 3 receptor in Nf1+/- brains at post natal day 15.
Gene_expression (expression) of dopamine 3 receptor in brains associated with dopamine
5) Confidence 0.60 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1434756 Disease Relevance 0.09 Pain Relevance 0.23
Other studies have confirmed the expression of modest amounts of mRNA for D2-receptors, but not of D1-receptors (Mansour et al., 1992; Hurd et al., 2001) or D3-receptors (Quik et al., 2000).
Gene_expression (expression) of D3-receptor
6) Confidence 0.58 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0 Pain Relevance 0.24
Some ET patients have the gly9 susceptibility variant of the DRD3 gene [40,41].
Gene_expression (variant) of DRD3 associated with tremor
7) Confidence 0.54 Published 2008 Journal J Transl Med Section Body Doc Link PMC2613385 Disease Relevance 0.84 Pain Relevance 0.10
Additionally, this treatment with bisphenol-A produced a down-regulation of dopamine D3 receptor and an up-regulation of dopamine D1 receptor function to activate G-protein in the mouse limbic forebrain, which is thought to play a critical role for rewarding effects by drugs of abuse.
Gene_expression (produced) of dopamine D3 receptor in forebrain associated with dopamine
8) Confidence 0.47 Published 2005 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 16045194 Disease Relevance 0.17 Pain Relevance 0.23
The time-course of altered D3 receptor expression, in line with the delayed clinical efficiency of antidepressant treatment, and the fact that various antidepressant drugs and ECT treatments eventually produced the same effects, suggest that increased expression of the D3 receptor in the shell of nucleus accumbens is a common neurobiological mechanism of antidepressant treatments, resulting in enhanced responsiveness to the mesolimbic dopaminergic system.
Gene_expression (expression) of D3 receptor in nucleus accumbens associated with nucleus accumbens and antidepressant
9) Confidence 0.35 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889548 Disease Relevance 0.07 Pain Relevance 0.89
The time-course of altered D3 receptor expression, in line with the delayed clinical efficiency of antidepressant treatment, and the fact that various antidepressant drugs and ECT treatments eventually produced the same effects, suggest that increased expression of the D3 receptor in the shell of nucleus accumbens is a common neurobiological mechanism of antidepressant treatments, resulting in enhanced responsiveness to the mesolimbic dopaminergic system.
Gene_expression (expression) of D3 receptor in nucleus accumbens associated with nucleus accumbens and antidepressant
10) Confidence 0.35 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889548 Disease Relevance 0.06 Pain Relevance 0.83
Here we examined the effects of chronic administration of antidepressants of several classes (amitriptyline, desipramine, imipramine, fluoxetine and tranylcypromine) and repeated electroconvulsive shock treatments (ECT) on dopamine D3 receptor expression in the shell of the nucleus accumbens, a major projection area of the mesolimbic dopaminergic system.
Gene_expression (expression) of D3 receptor in nucleus accumbens associated with nucleus accumbens, dopamine, desipramine, antidepressant, shock, endep and fluoxetine
11) Confidence 0.30 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889548 Disease Relevance 0.10 Pain Relevance 0.74
Selective increase of dopamine D3 receptor gene expression as a common effect of chronic antidepressant treatments.
Gene_expression (expression) of D3 receptor associated with antidepressant, dopamine and endep
12) Confidence 0.30 Published 2000 Journal Mol. Psychiatry Section Title Doc Link 10889548 Disease Relevance 0.08 Pain Relevance 0.73
In contrast, treatments for 21 days (with all drugs except fluoxetine) significantly increased D3 receptor mRNA expression in the shell of nucleus accumbens; D3 receptor binding was also significantly increased by amitriptyline or fluoxetine after a 42-day treatment.
Gene_expression (expression) of D3 receptor in nucleus accumbens associated with nucleus accumbens, endep and fluoxetine
13) Confidence 0.30 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889548 Disease Relevance 0.09 Pain Relevance 0.84
Short-term drug treatments had variable effects on D3 receptor mRNA expression.
Gene_expression (expression) of D3 receptor
14) Confidence 0.30 Published 2000 Journal Mol. Psychiatry Section Abstract Doc Link 10889548 Disease Relevance 0.09 Pain Relevance 0.79
DRD3 receptor is expressed in the thalamus and substantia nigra where limb-movement related neurons are present [42].
Gene_expression (expressed) of DRD3 in thalamus associated with substantia nigra and thalamus
15) Confidence 0.21 Published 2008 Journal J Transl Med Section Body Doc Link PMC2613385 Disease Relevance 0.82 Pain Relevance 0.10
-sulpiride, a D2 and D3 receptor antagonist devoid of activity on ?
Gene_expression (antagonist) of D3 receptor associated with antagonist
16) Confidence 0.12 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.34 Pain Relevance 1.17
The other DA receptors are less abundant in the striatum: the D3 receptor is mostly expressed in the ventral striatum (Diaz et al., 1995), the D5 receptor expression is low and widespread (Rivera et al., 2002), and the D4 receptor expression is not detected (NoaĆ­n et al., 2006).
Gene_expression (expressed) of D3 receptor in striatum associated with dopamine
17) Confidence 0.10 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.47
Chronic high dose L-dopa treatment does not alter the levels of dopamine D-1, D-2 or D-3 receptor in the striatum of normal monkeys: an autoradiographic study.
Gene_expression (levels) of D-3 receptor in striatum associated with dopamine
18) Confidence 0.06 Published 2001 Journal J Neural Transm Section Title Doc Link 11716146 Disease Relevance 0.32 Pain Relevance 0.28
Similarly, in the nucleus accumbens (NAc) and lateral septal nucleus (LSN), the majority of clozapine-induced FLI neurons express D3 receptor mRNA (NAc 69%; LS 73%).
Gene_expression (express) of D3 receptor mRNA in septal nucleus associated with nucleus accumbens
19) Confidence 0.02 Published 1998 Journal Neuropsychopharmacology Section Abstract Doc Link 9629567 Disease Relevance 0 Pain Relevance 1.26

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