INT75971

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Context Info
Confidence 0.45
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.96
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (B2m)
Anatomy Link Frequency
visceral 2
T cells 1
B2m (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 3 98.68 Very High Very High Very High
Inflammation 15 63.40 Quite High
Hippocampus 1 62.72 Quite High
interstitial cystitis 2 55.16 Quite High
abdominal pain 2 30.56 Quite Low
cytokine 9 5.00 Very Low Very Low Very Low
chemokine 7 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
diabetic neuropathy 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Amyloidosis 20 100.00 Very High Very High Very High
Metastasis 2 100.00 Very High Very High Very High
Disease 14 98.64 Very High Very High Very High
Hantavirus Infection 4 98.48 Very High Very High Very High
Sprains And Strains 129 97.36 Very High Very High Very High
Diabetes Mellitus 154 96.28 Very High Very High Very High
Ulcers 3 95.68 Very High Very High Very High
Autoimmune Disease 16 88.28 High High
Infection 12 86.00 High High
Fever 1 82.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dialysis-associated beta2-microglobulin (beta2m) amyloidosis affects predominantly musculoskeletal tissue, but visceral involvement also occurs.
Regulation (affects) of beta2-microglobulin in visceral associated with amyloidosis
1) Confidence 0.45 Published 1998 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 9630180 Disease Relevance 0.34 Pain Relevance 0
Dialysis-associated beta2-microglobulin (beta2m) amyloidosis affects predominantly musculoskeletal tissue, but visceral involvement also occurs.
Regulation (affects) of beta2m in visceral associated with amyloidosis
2) Confidence 0.45 Published 1998 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 9630180 Disease Relevance 0.34 Pain Relevance 0
Arresting dialysis-related amyloidosis: a prospective multicenter controlled trial of direct hemoperfusion with a beta2-microglobulin adsorption column.
Regulation (controlled) of beta2-microglobulin associated with pain and amyloidosis
3) Confidence 0.42 Published 2004 Journal Artif Organs Section Title Doc Link 15084199 Disease Relevance 0.41 Pain Relevance 0.17
Idd13 was found to work on nonhematopoietically derived cells controlling selection of diabetogenic T cells and/or their target pancreatic ß cells, and B2m-induced alterations in H2g7 class I conformation may partially explain these findings [22].
Regulation (controlling) of B2m in T cells
4) Confidence 0.36 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.51 Pain Relevance 0
Several genes exhibiting strain-dependent differences in prostate expression have been studied in the context of prostate development (for example, Sbp), androgen regulation (Fabp5, Odc), tumorigenesis (for example, Psca, Azgp1, Apod, Mmp7, Egf, Mgst1, Clusterin), and the progression of metastatic cancer (Cxcl12, B2m, H2 family members) [8].
Regulation (regulation) of B2m associated with sprains and strains and metastasis
5) Confidence 0.21 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394769 Disease Relevance 1.04 Pain Relevance 0.03
Repeated intravesical BCG treatment induced an up regulation of genes associated with antigen presentation (B2M, HLA-A, HLA-DQA1, HLA-DQB2, HLA-E, HLA-G, IGHG, and IGH) and representatives of two IFN?
Regulation (regulation) of B2M
6) Confidence 0.14 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2212656 Disease Relevance 0.17 Pain Relevance 0.09
During the clinical course, urinary beta-2M was the most sensitive marker for the evaluation of the disease activity of HPS.
Regulation (sensitive) of beta-2M associated with disease and hantavirus infection
7) Confidence 0.09 Published 2003 Journal Pediatr Hematol Oncol Section Abstract Doc Link 12775542 Disease Relevance 1.14 Pain Relevance 0.08

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