INT75978

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Context Info
Confidence 0.69
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 2.28
Pain Relevance 5.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gad2) lyase activity (Gad2) Golgi apparatus (Gad2)
cytoplasmic membrane-bounded vesicle (Gad2) plasma membrane (Gad2) cytoplasm (Gad2)
Anatomy Link Frequency
arcuate nucleus 3
nucleus 2
nucleus accumbens 1
neurons 1
Gad2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 24 100.00 Very High Very High Very High
dopamine receptor 12 100.00 Very High Very High Very High
Inflammation 35 99.72 Very High Very High Very High
Nucleus accumbens 9 99.20 Very High Very High Very High
cytokine 3 99.20 Very High Very High Very High
spinal dorsal horn 38 98.76 Very High Very High Very High
adenocard 5 97.88 Very High Very High Very High
qutenza 6 97.32 Very High Very High Very High
antagonist 7 96.32 Very High Very High Very High
Intracerebroventricular 3 95.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 35 99.72 Very High Very High Very High
Parkinson's Disease 46 98.90 Very High Very High Very High
Nociception 20 98.08 Very High Very High Very High
Hyperinsulinism 3 94.08 High High
Disease 82 93.52 High High
Generalized Anxiety Disorder 11 79.00 Quite High
Repression 1 75.00 Quite High
Dyskinesias 86 68.52 Quite High
Injury 5 66.72 Quite High
Pain 10 58.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, increases in the GABA-synthesizing enzyme glutamic acid decarboxylase 65 (GAD65) mRNA expression preceded decreases in NPY mRNA expression in the arcuate nucleus in the cultures.
Transcription (expression) of GAD65 in arcuate nucleus associated with gaba
1) Confidence 0.69 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16177033 Disease Relevance 0.08 Pain Relevance 0.90
In contrast, less than 25% of ENKergic cells expressed VGLUT1 in the lateral nucleus of the amygdale, with the majority of ENK cells expressing GAD65 mRNA in this nucleus.
Transcription (expressing) of GAD65 in nucleus
2) Confidence 0.51 Published 2008 Journal J. Comp. Neurol. Section Abstract Doc Link 18085591 Disease Relevance 0 Pain Relevance 0.19
Quantitative analysis at the cellular level indicated that GAD67 mRNA levels were increased in PPE-labeled neurons, whereas GAD65 mRNA levels were increased in PPE-unlabeled neurons.
Transcription (levels) of GAD65 in neurons
3) Confidence 0.50 Published 1999 Journal Synapse Section Abstract Doc Link 10380849 Disease Relevance 0 Pain Relevance 0.28
Quantitative densitometry was used to measure changes in mRNA levels for preproenkephalin A (ENK), D1 dopamine receptor, protachykinin (SubP), glutamic acid decarboxylase (GAD65), and D2 dopamine receptor.
Transcription (levels) of GAD65 associated with dopamine receptor
4) Confidence 0.49 Published 1998 Journal Brain Res. Section Abstract Doc Link 9630515 Disease Relevance 0 Pain Relevance 0.33
No differences were found between sham and lesion groups for ENK, D1, SubP, or GAD65 mRNA levels in the striatum or nucleus accumbens (NAC).
Transcription (levels) of GAD65 in nucleus accumbens associated with nucleus accumbens
5) Confidence 0.49 Published 1998 Journal Brain Res. Section Abstract Doc Link 9630515 Disease Relevance 0 Pain Relevance 0.35
Quantitative densitometry was used to measure changes in mRNA levels for preproenkephalin A (ENK), D1 dopamine receptor, protachykinin (SubP), glutamic acid decarboxylase (GAD65), and D2 dopamine receptor.
Transcription (levels) of glutamic acid decarboxylase associated with dopamine receptor
6) Confidence 0.49 Published 1998 Journal Brain Res. Section Abstract Doc Link 9630515 Disease Relevance 0 Pain Relevance 0.33
These include genes encoding GAD65 GABA synthesis enzyme, anti-inflammatory cytokine, IL-10, and GABAB1d, A1 adenosine, ?
Transcription (enzyme) of GAD65 associated with adenocard, gaba, inflammation and cytokine
7) Confidence 0.47 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 0.64 Pain Relevance 0.70
In rats, an ipsilateral marked up-regulation of GAD65/67 mRNA expression in the ENT nucleus has been reported following 6-OHDA lesion (Soghomonian and Chesselet, 1992; Barroso-Chinea et al., 2008).
Transcription (expression) of GAD65 in nucleus
8) Confidence 0.40 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2947938 Disease Relevance 0.46 Pain Relevance 0
In contrast, GAD65 mRNA levels remained low and were unaffected by the treatment, and EP10 was not detected.
Transcription (levels) of GAD65
9) Confidence 0.36 Published 1998 Journal Perspect Dev Neurobiol Section Abstract Doc Link 9777631 Disease Relevance 0.15 Pain Relevance 0.81
In the GPi of MPTP-treated monkeys, i.e., the main output structure, the expression of GAD67 and GAD65 mRNAs is increased (Pedneault and Soghomonian, 1994; Soghomonian et al., 1994; Herrero et al., 1996).
Transcription (expression) of GAD65 associated with parkinson's disease
10) Confidence 0.31 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2947938 Disease Relevance 0.78 Pain Relevance 0.04
Experiments in vivo also demonstrated that increases in GAD65 mRNA expression in the arcuate nucleus preceded decreases in the NPY mRNA expression in a fasting-refeeding paradigm and that intracerebroventricular injection of insulin increased GAD65 mRNA expression in the arcuate nucleus in fasted rats.
Transcription (expression) of GAD65 mRNA in arcuate nucleus associated with hyperinsulinism and intracerebroventricular
11) Confidence 0.28 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16177033 Disease Relevance 0.09 Pain Relevance 0.83
Furthermore, increases in the GABA-synthesizing enzyme glutamic acid decarboxylase 65 (GAD65) mRNA expression preceded decreases in NPY mRNA expression in the arcuate nucleus in the cultures.
Transcription (expression) of GABA-synthesizing enzyme glutamic acid decarboxylase 65 in arcuate nucleus associated with gaba
12) Confidence 0.25 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16177033 Disease Relevance 0.08 Pain Relevance 0.92

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