INT75995

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Context Info
Confidence 0.45
First Reported 1998
Last Reported 2005
Negated 0
Speculated 2
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.21
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf)
extracellular region (Ngf) molecular_function (Ngf)
Anatomy Link Frequency
neurons 2
dorsal root ganglion 2
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 7 100.00 Very High Very High Very High
Inflammation 6 95.48 Very High Very High Very High
Inflammatory response 2 93.00 High High
dorsal root ganglion 5 89.84 High High
Adelta 3 88.40 High High
nociceptor 7 87.28 High High
Hyperalgesia 1 82.08 Quite High
nav1.8 4 75.00 Quite High
Pain 5 50.00 Quite Low
Action potential 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Nociception 3 99.62 Very High Very High Very High
INFLAMMATION 6 95.48 Very High Very High Very High
Ganglion Cysts 5 89.84 High High
Pain 2 83.00 Quite High
Hyperalgesia 1 82.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it has not been clarified quantitatively whether disc herniation induces changes in nerve growth factor levels in the dorsal root ganglion in relation to pain-related behavior.
Spec (whether) Positive_regulation (induces) of Spec (whether) Regulation (changes) of nerve growth factor in dorsal root ganglion
1) Confidence 0.45 Published 2005 Journal Spine Section Body Doc Link 15644754 Disease Relevance 0.08 Pain Relevance 0
We provide the first evidence in single identified neurons that strong trkA expression in DRGs is restricted to nociceptive neurons, probably accounting for the profound influence of NGF on these neurons.
Spec (probably) Positive_regulation (accounting) of Regulation (influence) of NGF in neurons associated with nociception
2) Confidence 0.40 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15888662 Disease Relevance 0.59 Pain Relevance 0.63
NGF immunoreactivity was elevated with a similar time course to its mRNA.
Positive_regulation (elevated) of Regulation (immunoreactivity) of NGF associated with nerve growth factor
3) Confidence 0.25 Published 1998 Journal Neuroreport Section Abstract Doc Link 9631447 Disease Relevance 0.54 Pain Relevance 0.58

General Comments

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