INT75996

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Context Info
Confidence 0.67
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 4.03
Pain Relevance 3.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)
Anatomy Link Frequency
glial cell 2
spinal cord 1
brain 1
dorsal root ganglion 1
Ntf3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 15 100.00 Very High Very High Very High
Locus ceruleus 9 99.84 Very High Very High Very High
Spinal cord 356 99.68 Very High Very High Very High
dorsal root ganglion 6 99.44 Very High Very High Very High
Inflammation 44 99.24 Very High Very High Very High
withdrawal 6 99.16 Very High Very High Very High
Morphine 4 98.88 Very High Very High Very High
Inflammatory response 8 96.00 Very High Very High Very High
antagonist 1 95.72 Very High Very High Very High
antidepressant 37 92.84 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 48 100.00 Very High Very High Very High
INFLAMMATION 50 99.24 Very High Very High Very High
Ganglion Cysts 6 98.96 Very High Very High Very High
Nervous System Injury 3 98.08 Very High Very High Very High
Injury 19 88.16 High High
Immunization 2 86.44 High High
Multiple Sclerosis 8 85.20 High High
Hyperalgesia 1 85.08 High High
Disease 14 84.16 Quite High
Opiate Addiction 1 80.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, very high levels of BDNF, NT-3, and glial cell line-derived neurotrophic factor mRNAs were present in T and NK cell populations infiltrating the CNS.
Transcription (levels) of NT-3 in glial cell
1) Confidence 0.67 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10884312 Disease Relevance 0.71 Pain Relevance 0.08
Expression of neurotrophin mRNAs in the dorsal root ganglion after spinal nerve injury.
Transcription (Expression) of neurotrophin in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and nervous system injury
2) Confidence 0.50 Published 1999 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9931485 Disease Relevance 0.72 Pain Relevance 0.65
Despite significant production of NT3 by the selected hMSC-NT3 clone, only very low, but however significant, NT3 mRNA was produced by these cells (Figure 1C, hMSC-NT3 cells).
Transcription (produced) of NT3
3) Confidence 0.46 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0.22 Pain Relevance 0.10
In addition, very high levels of BDNF, NT-3, and glial cell line-derived neurotrophic factor mRNAs were present in T and NK cell populations infiltrating the CNS.
Transcription (levels) of neurotrophic factor in glial cell
4) Confidence 0.43 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10884312 Disease Relevance 0.73 Pain Relevance 0.08
Transgene expression of hMSC-NT3-EGFP cell transplants in rat spinal cord
Transcription (transplants) of hMSC-NT3-EGFP in spinal cord associated with spinal cord
5) Confidence 0.40 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0.28 Pain Relevance 0.12
Further investigation of transgene silencing in hMSC-NT3-EGFP cell transplants
Transcription (transplants) of hMSC-NT3-EGFP
6) Confidence 0.40 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0 Pain Relevance 0.10
While in vivo EGFP mRNA and protein expression by transplanted hMSC-EGFP cells was readily detectable at different time points post-transplantation, in vivo NT3 mRNA expression by hMSC-NT3 cells and in vivo EGFP protein expression by hMSC-NT3-EGFP cells was, respectively, undetectable or declined rapidly between day 1 and 7 post-transplantation.
Transcription (expression) of NT3
7) Confidence 0.35 Published 2007 Journal BMC Biotechnol Section Abstract Doc Link PMC2225398 Disease Relevance 0.07 Pain Relevance 0.16
Figure 1B shows a representative example for the detection of transgenic EGFP and NT3 DNA and mRNA by standard PCR and RT-PCR analysis on DNA and mRNA isolated from the different hMSC lines used in this study.
Transcription (detection) of NT3 associated with targeted disruption
8) Confidence 0.31 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0.24 Pain Relevance 0.03
Further investigation revealed that the observed in vivo decline of EGFP protein expression by hMSC-NT3-EGFP cells: (i) was associated with a decrease in transgenic NT3-EGFP mRNA expression as suggested following laser capture micro-dissection analysis of hMSC-NT3-EGFP cell transplants at day 1 and day 7 post-transplantation, (ii) did not occur when hMSC-NT3-EGFP cells were transplanted subcutaneously, and (iii) was reversed upon re-establishment of hMSC-NT3-EGFP cell cultures at 2 weeks post-transplantation.
Transcription (expression) of NT3-EGFP associated with targeted disruption
9) Confidence 0.31 Published 2007 Journal BMC Biotechnol Section Abstract Doc Link PMC2225398 Disease Relevance 0.28 Pain Relevance 0.11
Although chronic morphine exposure resulted in only modest increases in BDNF and NT-3 mRNA expression in LC, precipitated withdrawal led to a marked, rapid, and prolonged increase in BDNF mRNA and a delayed decrease in NT-3 mRNA.
Transcription (expression) of NT-3 associated with locus ceruleus, withdrawal and morphine
10) Confidence 0.11 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9852605 Disease Relevance 0.08 Pain Relevance 1.51
Figures 2 A, B show that NGF, NT-3, GDNF and BDNF transcription increased continuously over the 14 day cultivation period upon PMA treatment, while bFGF, CNTF and Creb showed a steady decline, but these changes were compensatory modulated by antidepressant drugs (Figure 2C–F).
Transcription (transcription) of NT-3 associated with antidepressant
11) Confidence 0.11 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2275236 Disease Relevance 0.06 Pain Relevance 0.35
Two hours, but not 6 or 24 h after induction of inflammation, there were significant increases in levels of NGF, brain-derived neurotrophic factor and neurotrophin-3 mRNAs.
Transcription (levels) of neurotrophin-3 in brain associated with nerve growth factor and inflammation
12) Confidence 0.08 Published 1998 Journal Neuroreport Section Abstract Doc Link 9631447 Disease Relevance 0.55 Pain Relevance 0.58
Samples of OMA and EE were processed by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) for NGF, BDNF, NT-3, NT-4/5 and NTRK2 mRNA expression.
Transcription (expression) of NT-3
13) Confidence 0.04 Published 2010 Journal Gynecol Obstet Fertil Section Body Doc Link 20579920 Disease Relevance 0.08 Pain Relevance 0

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