INT75997

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Context Info
Confidence 0.69
First Reported 1998
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 7.78
Pain Relevance 9.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf)
extracellular region (Ngf) molecular_function (Ngf)
Anatomy Link Frequency
nerve 4
mast cells 4
oligodendrocytes 3
fibroblasts 2
bladder 2
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 190 100.00 Very High Very High Very High
substance P 64 100.00 Very High Very High Very High
Serotonin 47 100.00 Very High Very High Very High
5HT 15 100.00 Very High Very High Very High
algogenic 12 100.00 Very High Very High Very High
qutenza 6 99.98 Very High Very High Very High
Inflammation 177 99.74 Very High Very High Very High
Dorsal horn 58 98.96 Very High Very High Very High
dorsal root ganglion 1 98.28 Very High Very High Very High
Chemotherapy induced neuropathy 3 98.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Asthma 10 100.00 Very High Very High Very High
Nervous System Injury 97 99.98 Very High Very High Very High
INFLAMMATION 194 99.74 Very High Very High Very High
Neuropathic Pain 61 98.12 Very High Very High Very High
Ganglion Cysts 7 97.80 Very High Very High Very High
Injury 49 95.76 Very High Very High Very High
Pox Virus Infection 1 94.12 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

21 93.56 High High
Hydrocephalus 56 92.96 High High
Hypersensitivity 25 92.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Astrocytes and oligodendrocytes can be induced to secrete NGF and NT-3 [13,14], and these cells are the most likely the source of NGF and NT-3 in CSF.
Positive_regulation (induced) of Localization (secrete) of NGF in oligodendrocytes associated with nerve growth factor
1) Confidence 0.69 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.62 Pain Relevance 0.78
Peripheral nerve damage triggers NGF release by macrophages, mast cells and Schwann cells, [10] and BDNF upregulation in trkA expressing DRG cells.
Positive_regulation (triggers) of Localization (release) of NGF in mast cells associated with nervous system injury
2) Confidence 0.49 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.75 Pain Relevance 0.52
These substances can directly stimulate the afferent neuron terminals but also can induce the release of algogenic substances (histamine, serotonin (5HT), nerve growth factor (NGF) and prostaglandins).
Positive_regulation (induce) of Localization (release) of nerve growth factor in nerve associated with nerve growth factor, algogenic, 5ht and serotonin
3) Confidence 0.33 Published 2010 Journal Gut Pathog Section Body Doc Link PMC2876056 Disease Relevance 0.30 Pain Relevance 1.14
Neurotropin inhibits both capsaicin-induced substance P release and nerve growth factor-induced neurite outgrowth in cultured rat dorsal root ganglion neurones.
Positive_regulation (induced) of Localization (release) of nerve growth factor in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nerve growth factor, qutenza and substance p
4) Confidence 0.30 Published 2010 Journal Clin. Exp. Dermatol. Section Title Doc Link 19874332 Disease Relevance 0.64 Pain Relevance 0.53
A possible explanation of the discrepancy in the findings is that autocrine action of endogenous NGF may be restricted to the neonatal period and that later spontaneous NGF release no longer affects lactotroph cell renewal unless NGF release is specifically activated.
Positive_regulation (activated) of Localization (release) of NGF in lactotroph associated with nerve growth factor
5) Confidence 0.28 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.56
NGF secretion has been shown to be activated by IL-1 (394) and VIP (389), whereas GHRH, TNF-?
Positive_regulation (whereas) of Localization (secretion) of NGF associated with nerve growth factor
6) Confidence 0.28 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.08 Pain Relevance 0.60
Our results suggest that during bladder inflammation, endogenous NGF is rapidly up-regulated and released to mediating sensory and reflex changes.
Positive_regulation (up-regulated) of Localization (released) of NGF in bladder associated with nerve growth factor and inflammation
7) Confidence 0.25 Published 1998 Journal Neuroreport Section Abstract Doc Link 9631447 Disease Relevance 0.52 Pain Relevance 0.56
These substances can directly stimulate the afferent neuron terminals but also can induce the release of algogenic substances (histamine, serotonin (5HT), nerve growth factor (NGF) and prostaglandins).
Positive_regulation (induce) of Localization (release) of NGF in nerve associated with nerve growth factor, algogenic, 5ht and serotonin
8) Confidence 0.24 Published 2010 Journal Gut Pathog Section Body Doc Link PMC2876056 Disease Relevance 0.30 Pain Relevance 1.14
Astrocytes and oligodendrocytes can be induced to secrete NGF and NT-3 [13,14], and these cells are the most likely the source of NGF and NT-3 in CSF.
Positive_regulation (induced) of in Astrocytes Localization (secrete) of NGF in oligodendrocytes associated with nerve growth factor
9) Confidence 0.24 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.62 Pain Relevance 0.78
The release of substance P from the neuron terminals induces the production and release of histamine and NGF from mast cells.
Positive_regulation (induces) of Localization (release) of NGF in neuron associated with nerve growth factor and substance p
10) Confidence 0.22 Published 2010 Journal Gut Pathog Section Body Doc Link PMC2876056 Disease Relevance 0.23 Pain Relevance 0.97
IL-6 was compared to four-methylcatechol (4-MC)-a known inducer of NGF secretion previously shown to exhibit neuroprotective effects in CIN models.
Positive_regulation (inducer) of Localization (secretion) of NGF associated with chemotherapy induced neuropathy
11) Confidence 0.17 Published 2008 Journal Cancer Chemother. Pharmacol. Section Abstract Doc Link 18270703 Disease Relevance 0.29 Pain Relevance 0.33
Peripheral nerve damage triggers NGF release by macrophages, mast cells and Schwann cells, [10] and BDNF upregulation in trkA expressing DRG cells.
Positive_regulation (triggers) of in macrophages Localization (release) of NGF in mast cells associated with nervous system injury
12) Confidence 0.17 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.75 Pain Relevance 0.52
Peripheral nerve damage triggers NGF release by macrophages, mast cells and Schwann cells, [10] and BDNF upregulation in trkA expressing DRG cells.
Positive_regulation (triggers) of in Schwann cells Localization (release) of NGF in mast cells associated with nervous system injury
13) Confidence 0.17 Published 2008 Journal Mol Pain Section Body Doc Link PMC2614976 Disease Relevance 0.75 Pain Relevance 0.52
Nerve growth factor, which is closely associated with asthma, is released from lung fibroblasts at an increased rate when exposed to TNF-?
Positive_regulation (increased) of Localization (released) of Nerve growth factor in fibroblasts associated with asthma and nerve growth factor
14) Confidence 0.11 Published 2008 Journal Clinical Medicine. Circulatory, Respiratory and Pulmonary Medicine Section Body Doc Link PMC2990232 Disease Relevance 1.51 Pain Relevance 0.47

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