INT75998

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Context Info
Confidence 0.69
First Reported 1998
Last Reported 2011
Negated 1
Speculated 3
Reported most in Body
Documents 61
Total Number 64
Disease Relevance 11.03
Pain Relevance 8.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (BDNF) cytoplasmic membrane-bounded vesicle (BDNF)
Anatomy Link Frequency
brain 14
hippocampus 4
dendrites 3
SH-SY5Y 2
medulla 1
BDNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 79 100.00 Very High Very High Very High
antidepressant 464 99.84 Very High Very High Very High
Hippocampus 283 99.68 Very High Very High Very High
Central nervous system 43 99.68 Very High Very High Very High
Inflammation 40 99.24 Very High Very High Very High
cerebral cortex 108 99.16 Very High Very High Very High
amygdala 108 98.48 Very High Very High Very High
medulla 70 96.72 Very High Very High Very High
Inflammatory response 2 96.00 Very High Very High Very High
tolerance 38 95.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 443 99.48 Very High Very High Very High
INFLAMMATION 40 99.24 Very High Very High Very High
Depression 294 99.12 Very High Very High Very High
Urological Neuroanatomy 38 98.48 Very High Very High Very High
Death 19 96.38 Very High Very High Very High
Neuroblastoma 102 95.96 Very High Very High Very High
Frailty 6 95.68 Very High Very High Very High
Neurodegenerative Disease 71 95.04 Very High Very High Very High
Pain 44 91.08 High High
Disease 63 90.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As an example, it has been shown that different BDNF promoters contain multiple sites for various transcription factors (i.e.
Transcription (transcription) of BDNF
1) Confidence 0.69 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.15 Pain Relevance 0.24
Therefore, aim of the present study was to investigate whether antidepressant treatments of different time lengths induce changes in the expression of BDNF gene also in cultured human cells and to assess whether these modifications could be explained by differential regulation of BDNF transcripts.
Transcription (transcripts) of BDNF associated with antidepressant
2) Confidence 0.69 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.23 Pain Relevance 0.15
Interestingly, previous studies in rodents have shown a differential regulation of distinct BDNF transcripts by antidepressant treatments [6,9,11].
Transcription (transcripts) of BDNF associated with antidepressant
3) Confidence 0.69 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.18 Pain Relevance 0.44
However, as Figure 1 shows, when the BDNF mRNA level in blood from eight control participants was normalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA or ?
Transcription (normalized) of BDNF mRNA in blood
4) Confidence 0.68 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0.43 Pain Relevance 0.03
As shown, the distribution of the BDNF mRNA values normalized to EARs is tighter with respect to the distribution of BDNF mRNA normalized to GAPDH or ?
Transcription (distribution) of BDNF mRNA
5) Confidence 0.68 Published 2010 Journal Genome Biol Section Body Doc Link PMC2847721 Disease Relevance 0 Pain Relevance 0
Fewer data are available about BDNF mRNA expression.
Transcription (expression) of BDNF
6) Confidence 0.64 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.09
We found that BDNF transcripts containing exons II, III, IV, V, and VII are mostly brain-specific, whereas other BDNF mRNAs are also expressed at variable levels in nonneural tissues.
Transcription (expressed) of BDNF in brain
7) Confidence 0.64 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0
In the adult human brain, high levels of BDNF mRNAs were present in the hippocampus, cerebral cortex, amygdala, and cerebellum, which is similar to the previously reported data on the BDNF expression in rodent brain [10,11,15,27,28].
Transcription (present) of BDNF in brain associated with hippocampus, amygdala and cerebral cortex
8) Confidence 0.64 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.15
Other possible regulatory functions of antiBDNF would be direct inhibition of BDNF transcription or translation and/or regulation of BDNF pre-mRNA splicing.
Transcription (transcription) of BDNF
9) Confidence 0.64 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.05
The highest expression levels of the D. labrax BDNF transcripts were observed in the brain even though some variants, such as 1b/2 and 1c/2, were detected also in non neuronal tissues even if only after a second round of PCR.
Transcription (transcripts) of BDNF in neuronal
10) Confidence 0.61 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829032 Disease Relevance 0 Pain Relevance 0
Analysis of D. labrax BDNF transcripts, carried out both in the early developmental stages and in adult tissues, shows that all alternative upstream exons (1?
Transcription (transcripts) of BDNF in developmental stages
11) Confidence 0.61 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829032 Disease Relevance 0.25 Pain Relevance 0
Expression analysis of human BDNF and antiBDNF transcripts in 30 different adult brain regions was performed by RT-PCR (Fig. 4).
Transcription (transcripts) of BDNF in adult brain
12) Confidence 0.61 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.08 Pain Relevance 0.11
BDNF/antiBDNF RNA duplex analyses
Spec (analyses) Transcription (analyses) of BDNF
13) Confidence 0.61 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0
Second, to identify novel BDNF transcripts and to determine the transcription start sites for the human BDNF transcripts, 5?
Transcription (transcripts) of BDNF
14) Confidence 0.61 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.15
Other possible regulatory functions of antiBDNF would be direct inhibition of BDNF transcription or translation and/or regulation of BDNF pre-mRNA splicing.
Transcription (transcription) of BDNF
15) Confidence 0.61 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.05
Second, in most cases, the usage of alternative promoters in the human BDNF gene leads to the expression of transcripts with different 5?
Transcription (usage) of BDNF
16) Confidence 0.61 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0
We named the gene and transcripts transcribed from the opposite strand of BDNF as antiBDNF (for antisense BDNF; part of it is described by Liu and colleagues and designated as OSBDNF—Liu et al. [19]).
Transcription (transcribed) of BDNF
17) Confidence 0.61 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0
Our results show that the expression of antiBDNF and BDNF transcripts in different tissues is not mutually exclusive and that the levels of BDNF mRNA do not appear to be specifically reduced in tissues that express high levels of antiBDNF transcripts.
Transcription (levels) of BDNF
18) Confidence 0.61 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.04
All BDNF transcripts except the ones containing exons V and VII were expressed at high levels in the cerebellum and medulla, and all transcripts but those containing exon IXabcd were expressed at high levels in the infundibulum.
Transcription (transcripts) of BDNF in medulla associated with medulla
19) Confidence 0.61 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0.10 Pain Relevance 0.22
According to the most recent description of the organization of the human BDNF gene locus and alternatively spliced transcripts the human BDNF has seven noncoding and one coding exon [19].
Transcription (description) of BDNF
20) Confidence 0.61 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0.17

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