INT75999

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Context Info
Confidence 0.78
First Reported 1998
Last Reported 2011
Negated 7
Speculated 20
Reported most in Body
Documents 344
Total Number 364
Disease Relevance 114.19
Pain Relevance 83.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (BDNF) cytoplasmic membrane-bounded vesicle (BDNF)
Anatomy Link Frequency
brain 52
nerve 14
annulus 9
neuronal 6
neurons 6
BDNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 3193 100.00 Very High Very High Very High
substance P 599 100.00 Very High Very High Very High
bDMF 562 100.00 Very High Very High Very High
Neuropeptide 552 100.00 Very High Very High Very High
fibrosis 18 100.00 Very High Very High Very High
Calcitonin gene-related peptide 44 99.96 Very High Very High Very High
antidepressant 1537 99.92 Very High Very High Very High
cytokine 1251 99.92 Very High Very High Very High
Angina 4 99.92 Very High Very High Very High
Hippocampus 1003 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Schizophrenia 142 100.00 Very High Very High Very High
Fibrosis 24 100.00 Very High Very High Very High
Stress 2088 99.92 Very High Very High Very High
Cv General 3 Under Development 223 99.92 Very High Very High Very High
Disease 2805 99.84 Very High Very High Very High
Cv General 4 Under Development 981 99.84 Very High Very High Very High
Status Epilepticus 2 99.84 Very High Very High Very High
Depression 1570 99.80 Very High Very High Very High
Stroke 733 99.80 Very High Very High Very High
INFLAMMATION 680 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BDNF was expressed in atheromatous intima and adventitia in human coronary artery.
Gene_expression (expressed) of BDNF in coronary artery
1) Confidence 0.78 Published 2009 Journal Ann Cardiol Angeiol (Paris) Section Abstract Doc Link 19281964 Disease Relevance 0.54 Pain Relevance 0.14
Because of the significance of BDNF in the IVD, our objectives in the present work were to use immunocytochemistry to determine the distribution of BDNF and its receptor in the human IVD, and to test for gene expression of BDNF and its receptor in cultured human annulus fibrosus cells.


Gene_expression (expression) of BDNF in annulus fibrosus
2) Confidence 0.78 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0.25 Pain Relevance 0.18
In particular, it has been shown that chronic defeat stress, a model of depression, selectively down-regulated in mouse hippocampus the expression of BDNF III and BDNF IV transcripts (corresponding in the present study to BDNF IV and BDNF VIa/b respectively, according to the new nomenclature of BDNF gene), while chronic imipramine treatment reversed this down-regulation [12].
Gene_expression (expression) of BDNF III in hippocampus associated with stress, depression and hippocampus
3) Confidence 0.78 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.20 Pain Relevance 0.37
In particular, it has been shown that chronic defeat stress, a model of depression, selectively down-regulated in mouse hippocampus the expression of BDNF III and BDNF IV transcripts (corresponding in the present study to BDNF IV and BDNF VIa/b respectively, according to the new nomenclature of BDNF gene), while chronic imipramine treatment reversed this down-regulation [12].
Gene_expression (expression) of BDNF IV in hippocampus associated with stress, depression and hippocampus
4) Confidence 0.78 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.20 Pain Relevance 0.37
Therefore, aim of the present study was to investigate whether antidepressant treatments of different time lengths induce changes in the expression of BDNF gene also in cultured human cells and to assess whether these modifications could be explained by differential regulation of BDNF transcripts.
Gene_expression (expression) of BDNF gene associated with antidepressant
5) Confidence 0.78 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.21 Pain Relevance 0.16
The fact that the selected significant genes, such as TrkB and SERPINE2, could lead to the correct conclusion regarding the level of BDNF expression in AD affected samples highlights the merits of this kind of analysis of the transcriptome when handling genes with low expression levels.
Gene_expression (expression) of BDNF associated with disease and bdmf
6) Confidence 0.76 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.89 Pain Relevance 0.34
Future investigation is needed to elucidate the relationship between primary sensory neuron subpopulations and changes in neuropeptide and neurotrophin expression on experimental levator ani nerve damage, childbirth, and aging.


Gene_expression (expression) of neurotrophin in nerve
7) Confidence 0.75 Published 2006 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 16635454 Disease Relevance 0 Pain Relevance 0
Here, we show that AAV-mediated overexpression of GDNF and BDNF in the spinal cord persisted for at least 16 weeks.
Gene_expression (overexpression) of BDNF in spinal cord associated with spinal cord
8) Confidence 0.75 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15380481 Disease Relevance 0.16 Pain Relevance 0.13
Most of the differential regulations, including overexpression of genes and proteins related to neurotrophin and inflammatory-immune system, occurred around 12 and 24 hours.
Gene_expression (overexpression) of neurotrophin in immune system associated with inflammation
9) Confidence 0.75 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2830184 Disease Relevance 0.77 Pain Relevance 0.43
For example, plasmids expressing vascular endothelial growth factor injected into muscle, or herpes-simplex-virus-based vectors expressing neurotrophin gene products delivered to dorsal root ganglion neurons, have been used to protect peripheral nerve function in animal models of diabetes-associated peripheral neuropathy.
Gene_expression (expressing) of neurotrophin in dorsal root ganglion associated with ganglion cysts, diabetes mellitus, root ganglion neuron and peripheral neuropathy
10) Confidence 0.75 Published 2007 Journal Expert Rev Mol Med Section Abstract Doc Link 17367556 Disease Relevance 0.82 Pain Relevance 0.28
In the current study, we have demonstrated expression of both high and low affinity receptors for neurotrophins by human BMSC, with their level of expression varying between BMSC donors (Figure 1A–D).
Gene_expression (expression) of neurotrophin
11) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.50 Pain Relevance 0
Further validation of proliferation arrest in neuronal precursor cells and reduced DCX expression with progressive infection was obtained from decreased expression of neurotrophins, such as BDNF and NT3.
Gene_expression (expression) of neurotrophin in precursor cells associated with neurotrophin 3 and infection
12) Confidence 0.75 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.99 Pain Relevance 0.17
Based on this knowledge we hypothesised that expression of the neurotrophins NGF and BDNF increases with disc degeneration and that they are regulated by IL-1?
Gene_expression (expression) of neurotrophin associated with intervertebral disk degeneration and nerve growth factor
13) Confidence 0.75 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.23 Pain Relevance 0.38
In rodent studies, mouse pups receiving high levels of maternal care show increased neurotrophin levels in the brain, which promotes sociability in adulthood[7].
Gene_expression (levels) of neurotrophin in brain
14) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714966 Disease Relevance 0.12 Pain Relevance 0.10
Thus, out of necessity, a new direction for neurotrophin research has developed to study the production and anterograde transport of neurotrophins.
Gene_expression (production) of neurotrophin
15) Confidence 0.75 Published 1999 Journal Microsc. Res. Tech. Section Abstract Doc Link 10383115 Disease Relevance 0 Pain Relevance 0.25
Nerve growth factor (NGF) is a neurotrophin produced in peripheral tissues that can also mediate pain and inflammation.
Gene_expression (produced) of neurotrophin in Nerve associated with pain, inflammation and nerve growth factor
16) Confidence 0.75 Published 2001 Journal Urology Section Abstract Doc Link 11378049 Disease Relevance 0.59 Pain Relevance 0.84
Together with the group of Virchow et al, we have more recently shown that neurotrophin production is increased in bronchoalveolar lavage fluids from patients undergoing segmental allergen provocation.
Gene_expression (production) of neurotrophin
17) Confidence 0.75 Published 2001 Journal Respir Res Section Body Doc Link PMC59513 Disease Relevance 0.77 Pain Relevance 0.35
Some agents modulate the expression of the neurotrophins themselves, while others act by enhancing neurotrophin action.
Gene_expression (expression) of neurotrophin
18) Confidence 0.75 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.39 Pain Relevance 0.13
What are the functional effects of increased neurotrophin production during the allergic response?
Gene_expression (production) of neurotrophin associated with hypersensitivity
19) Confidence 0.75 Published 2001 Journal Respir Res Section Body Doc Link PMC59513 Disease Relevance 0.66 Pain Relevance 0.28
In Ts65Dn mice, fluoxetine treatment restored the expression of 5-HT1A receptors and BDNF.
Gene_expression (expression) of BDNF associated with fluoxetine
20) Confidence 0.75 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20592198 Disease Relevance 0.88 Pain Relevance 0.43

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