INT760

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 1979
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 1.65
Pain Relevance 5.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Scn8a) transmembrane transport (Scn8a)
Anatomy Link Frequency
spike 1
cerebral cortex 1
gonadotroph 1
neuromuscular junction 1
anterior pituitary 1
Scn8a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 30 99.98 Very High Very High Very High
isoflurane 138 99.08 Very High Very High Very High
agonist 8 98.36 Very High Very High Very High
Nicotine 7 98.08 Very High Very High Very High
cerebral cortex 4 97.92 Very High Very High Very High
Action potential 51 97.76 Very High Very High Very High
noradrenaline 9 97.20 Very High Very High Very High
sodium channel 19 97.08 Very High Very High Very High
lidocaine 10 95.84 Very High Very High Very High
depression 45 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 45 95.76 Very High Very High Very High
Arrhythmias 2 Under Development 9 95.32 Very High Very High Very High
Bronchospasm 2 94.36 High High
Cv General 3 Under Development 1 93.76 High High
Angina 1 92.72 High High
Pressure Volume 2 Under Development 9 92.24 High High
Increased Venous Pressure Under Development 1 91.72 High High
Ectopic Atrial Tachycardia 1 84.92 Quite High
Emergencies 1 81.48 Quite High
Ganglion Cysts 2 76.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To study whether the inhibition of Na+-channels is involved in the action of GBR-12909 on the nicotine-evoked [(3)H]NA release, we compared the effect of GBR-12909 and the Na(+)-channel blocker tetrodotoxin (TTX) on the electrical stimulation- and nicotine-evoked response.
Spec (whether) Negative_regulation (inhibition) of Na+-channel associated with tetrodotoxin, nicotine and noradrenaline
1) Confidence 0.42 Published 2007 Journal Neuroscience Section Abstract Doc Link 17207584 Disease Relevance 0 Pain Relevance 1.07
Agents such as tetrodotoxin (1 microM), which block the Na+-channel, also appear to block the high-affinity agonist binding site or to convert it into a low-affinity agonist binding form.
Negative_regulation (block) of Na+-channel associated with tetrodotoxin and agonist
2) Confidence 0.41 Published 1987 Journal Acta Chem. Scand., B, Org. Chem. Biochem. Section Abstract Doc Link 2450433 Disease Relevance 0 Pain Relevance 0.36
Effects of depolarizing agents and Na+-channel inhibitors on ligand binding to muscarinic receptors from rat cerebral cortex.
Negative_regulation (inhibitors) of Na+-channel in cerebral cortex associated with cerebral cortex
3) Confidence 0.36 Published 1987 Journal Acta Chem. Scand., B, Org. Chem. Biochem. Section Title Doc Link 2450433 Disease Relevance 0 Pain Relevance 0.34
All six drugs suppressed the Na channel, the effect being strongest with etafenone, followed in order by quinidine, propranolol, disopyramide, lidocaine, and procainamide.
Negative_regulation (suppressed) of Na channel associated with lidocaine
4) Confidence 0.35 Published 1979 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 94412 Disease Relevance 0 Pain Relevance 0.34
Only quinidine, disopyramide, and propranolol suppressed the Ca channel and only in concentrations higher than those required to block the Na channel.
Negative_regulation (block) of Na channel
5) Confidence 0.35 Published 1979 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 94412 Disease Relevance 0 Pain Relevance 0.33
The action potentials were suppressed by specific Ca-channel inhibitors such as Co2+, La3+ and Verapamil, but they were resistant to Na-channel inhibitor, tetrodotoxin, even at 30 microM.
Negative_regulation (inhibitor) of Na-channel associated with tetrodotoxin and action potential
6) Confidence 0.35 Published 1979 Journal J. Membr. Biol. Section Abstract Doc Link 480340 Disease Relevance 0.08 Pain Relevance 0.32
NaCh6/Scn8a/rPN4 was inhibited by tetrodotoxin with an IC50 approximately 1 nM.
Negative_regulation (inhibited) of Scn8a associated with tetrodotoxin
7) Confidence 0.18 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9603190 Disease Relevance 0 Pain Relevance 0.37
The mechanism by which TTX Na channel blockade augments secretagogue-induced LH secretion is unknown; however, the data are interpreted as favoring direct action of TTX on the gonadotroph, with Na channel blockade affecting a site or sites common to both LHRH and elevated extracellular [K+].
Negative_regulation (blockade) of Na channel in gonadotroph associated with tetrodotoxin
8) Confidence 0.10 Published 1991 Journal Endocrinology Section Abstract Doc Link 1989862 Disease Relevance 0 Pain Relevance 0.81
We used two experimental systems, proestrous rat anterior pituitary tissue superfusion and 17 beta-estradiol-treated rat anterior pituitary cells in primary culture, to examine the effect of Na channel inhibition on LH secretion.
Spec (examine) Negative_regulation (inhibition) of Na channel in anterior pituitary
9) Confidence 0.10 Published 1991 Journal Endocrinology Section Abstract Doc Link 1989862 Disease Relevance 0 Pain Relevance 0.52
The direct effects include binding to Na-K ATPase complex and thus inhibiting Na channel.
Negative_regulation (inhibiting) of Na channel
10) Confidence 0.05 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2490802 Disease Relevance 1.43 Pain Relevance 0.27
Unlike TTX, isoflurane at clinical concentrations doesn't appear to inhibit Na channel activity in hippocampal Schaffer-collateral fibers.
Negative_regulation (inhibit) of Na channel associated with isoflurane
11) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1369004 Disease Relevance 0.15 Pain Relevance 0.41
In addition, Sandstrom [17] reported that isoflurane reduced presynaptic excitability in the phylogenetically distant larval Drosophila glutamatergic neuromuscular junction – an effect that is also consistent with Na channel inhibition.
Negative_regulation (inhibition) of Na channel in neuromuscular junction associated with isoflurane
12) Confidence 0.02 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1369004 Disease Relevance 0 Pain Relevance 0.41
We find that spike threshold depends logarithmically on Na channel density, and that Na channel inactivation and K channels can dynamically modulate it in an adaptive way: the threshold increases with membrane potential and after every action potential.
Negative_regulation (inactivation) of Na channel in spike associated with action potential
13) Confidence 0.01 Published 2010 Journal PLoS Computational Biology Section Abstract Doc Link PMC2900290 Disease Relevance 0 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox