INT7601

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Context Info
Confidence 0.33
First Reported 1992
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.77
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Scn11a) transmembrane transport (Scn11a)
Anatomy Link Frequency
neurons 1
DRG 1
Scn11a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
addiction 2 99.80 Very High Very High Very High
dorsal root ganglion 18 98.92 Very High Very High Very High
guanethidine 2 98.64 Very High Very High Very High
Sciatic nerve 8 96.76 Very High Very High Very High
sodium channel 2 87.76 High High
qutenza 3 79.64 Quite High
tetrodotoxin-resistant sodium channels 2 75.00 Quite High
Root ganglion neuron 2 75.00 Quite High
Peripheral nerve injury 2 56.00 Quite High
agonist 1 43.76 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 20 98.92 Very High Very High Very High
Injury 2 96.60 Very High Very High Very High
Nervous System Injury 4 75.00 Quite High
Overactive Bladder 3 75.00 Quite High
Abnormal Reflex 1 72.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a significant decrease in SNS and NaN signal intensity in small DRG neurons after peripheral, but not central, axotomy compared with control neurons.
Negative_regulation (decrease) of NaN in DRG associated with dorsal root ganglion
1) Confidence 0.33 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11007885 Disease Relevance 0.86 Pain Relevance 0.70
An attenuation of SNS and NaN transcripts has been demonstrated in small DRG neurons after transection of the sciatic nerve.
Negative_regulation (attenuation) of NaN in neurons associated with dorsal root ganglion and sciatic nerve
2) Confidence 0.33 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 11007885 Disease Relevance 0.69 Pain Relevance 0.59
The inhibitory effect of spiroxatrine, NAN-190 and buspirone was not reduced by guanethidine pretreatment.
Negative_regulation (effect) of NAN-190 associated with guanethidine
3) Confidence 0.28 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1352548 Disease Relevance 0.22 Pain Relevance 0.24

General Comments

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