INT76062

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Context Info
Confidence 0.10
First Reported 1998
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gnrhr) signal transducer activity (Gnrhr)
Anatomy Link Frequency
anterior 2
Gnrhr (Rattus norvegicus)
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 8 99.84 Very High Very High Very High
Analgesic 4 99.16 Very High Very High Very High
antagonist 12 97.12 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, SP stimulated the GnRH-induced LH secretion in the presence of progesterone alone.
GnRH-induced Positive_regulation (induced) of Localization (secretion) of LH
1) Confidence 0.10 Published 1998 Journal Neuropeptides Section Abstract Doc Link 9639246 Disease Relevance 0 Pain Relevance 0.20
In the absence of steroids or in the presence of 17beta estradiol, or a combination of 17beta estradiol and progesterone, SP inhibited the GnRH-induced LH release.
GnRH-induced Positive_regulation (induced) of Localization (release) of LH
2) Confidence 0.10 Published 1998 Journal Neuropeptides Section Abstract Doc Link 9639246 Disease Relevance 0 Pain Relevance 0.20
The in vitro effect of substance P on the GnRH-induced LH release depends on the steroidal environment and is reverted by a NK1 receptor antagonist (RP 67580) in the cycling female rat.
GnRH-induced Positive_regulation (induced) of Localization (release) of LH associated with analgesic, antagonist and substance p
3) Confidence 0.10 Published 1998 Journal Neuropeptides Section Title Doc Link 9639246 Disease Relevance 0 Pain Relevance 0.32
The present study used perifused anterior pituitaries from proestrous morning female rats and showed that the SP modulation of the GnRH-induced LH release is markedly dependent on the steroidal environment.
GnRH-induced Positive_regulation (induced) of Localization (release) of LH in anterior
4) Confidence 0.10 Published 1998 Journal Neuropeptides Section Abstract Doc Link 9639246 Disease Relevance 0 Pain Relevance 0.20

General Comments

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